Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aubrie A. Harland"'
Autor:
David Earl Nichols, Alia H. Clark, Juan Pablo Cueva, John D. McCorvy, Aubrie A. Harland, Val J. Watts
Publikováno v:
ARKIVOC, Vol 2010, Iss 4, Pp 125-138 (2011)
Externí odkaz:
https://doaj.org/article/401fb58cb6f043b18033cc66ca125cc1
Autor:
Aubrie A Harland, Steven G. Kinsey, Kim Wix, Shane W Kaski, Allison N White, Kristen R Trexler, Vincent Setola, Jeffrey Aubé, Terry P. Kenakin, David P. Siderovski, Joshua D Gross, Thomas E. Prisinzano
Publikováno v:
J Pharmacol Exp Ther
Mu opioid receptor (MOR)-targeting analgesics are efficacious pain treatments, but notorious for their abuse potential. In preclinical animal models, coadministration of traditional kappa opioid receptor (KOR)-targeting agonists with MOR-targeting an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590e1e6e2c01d88146faf230eeecacf0
https://doi.org/10.1124/jpet.118.255661
https://doi.org/10.1124/jpet.118.255661
Autor:
Anthony F. Nastase, Jessica P. Anand, Tyler J. Trask, Henry I. Mosberg, Emily M. Jutkiewicz, Thomas J Fernandez, Nicholas W. Griggs, John R. Traynor, Aubrie A. Harland
Publikováno v:
ACS Chem Neurosci
The use of opioids for the treatment of pain, while largely effective, is limited by detrimental side effects including analgesic tolerance, physical dependence, and euphoria, which may lead to opioid abuse. Studies have shown that compounds with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2aa9cd90a3cb78894dd62220fff74cb
https://doi.org/10.1021/acschemneuro.8b00139
https://doi.org/10.1021/acschemneuro.8b00139
Autor:
Henry I. Mosberg, Aubrie A. Harland, Irina D. Pogozheva, Nicholas W. Griggs, John R. Traynor, Tyler J. Trask
Publikováno v:
ACS Chemical Neuroscience
In an effort to expand the structure–activity relationship (SAR) studies of a series of mixed-efficacy opioid ligands, peptidomimetics that incorporate methoxy and hydroxy groups around a benzyl or 2-methylindanyl pendant on a tetrahydroquinoline (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60a19333a22d3ae99d697cda0dce990
https://doi.org/10.1021/acschemneuro.7b00284
https://doi.org/10.1021/acschemneuro.7b00284
Autor:
Chao Gao, Henry I. Mosberg, Nicholas W. Griggs, John R. Traynor, Aaron M. Bender, Emily M. Jutkiewicz, Irina D. Pogozheva, Jessica P. Anand, Aubrie A. Harland
Publikováno v:
Journal of Medicinal Chemistry
N-Acetylation of the tetrahydroquinoline (THQ) core of a series of μ-opioid receptor (MOR) agonist/δ-opioid receptor (DOR) antagonist ligands increases DOR affinity, resulting in ligands with balanced MOR and DOR affinities. We report a series of N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28aa24f12d4288bfccf2f67e3b7752ea
https://pubmed.ncbi.nlm.nih.gov/27148755
https://pubmed.ncbi.nlm.nih.gov/27148755
Autor:
Irina D. Pogozheva, Larisa Yeomans, Jessica P. Anand, Emily M. Jutkiewicz, John R. Traynor, Henry I. Mosberg, Nicholas W. Griggs, Aubrie A. Harland
Publikováno v:
Journal of medicinal chemistry. 58(22)
In a previously described peptidomimetic series, we reported the development of bifunctional μ-opioid receptor (MOR) agonist and δ-opioid receptor (DOR) antagonist ligands with a lead compound that produced antinociception for 1 h after intraperito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7350d3d9aab9794ca9e945e2fbe7e61
https://pubmed.ncbi.nlm.nih.gov/26524472
https://pubmed.ncbi.nlm.nih.gov/26524472
Autor:
Katarzyna Sobczyk-Kojiro, John R. Traynor, Emily M. Jutkiewicz, Aaron M. Bender, Henry I. Mosberg, Larisa Yeomans, Aubrie A. Harland, Mary J. Clark, Jessica P. Anand
Publikováno v:
Journal of medicinal chemistry. 56(5)
We have previously described opioid peptidomimetic, 1, employing a tetrahydroquinoline scaffold and modeled on a series of cyclic tetrapeptide opioid agonists. We have recently described modifications to these peptides that confer a mu opioid recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4bf88ecfe0ad8074ea7c246909a96c
https://pubmed.ncbi.nlm.nih.gov/23419026
https://pubmed.ncbi.nlm.nih.gov/23419026
Publikováno v:
Neuroscience letters. 505(1)
This study was designed to determine whether a 5-HT 2C receptor antagonist could induce a conditioned place preference indicative of reward and/or abuse potential. Here, we present the first evidence that a selective 5-HT 2C receptor antagonist, 6-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccf3a05f657b5999cba11e1725e5874
https://pubmed.ncbi.nlm.nih.gov/21827831
https://pubmed.ncbi.nlm.nih.gov/21827831