Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Aubrey S. Smith"'
Autor:
Camila P. Camargo, Abir K. Muhuri, Yunus Alapan, Lauren F. Sestito, Megha Khosla, Margaret P. Manspeaker, Aubrey S. Smith, Chrystal M. Paulos, Susan N. Thomas
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112175- (2023)
Summary: CD8+ T cell recruitment to the tumor microenvironment is critical for the success of adoptive cell therapy (ACT). Unfortunately, only a small fraction of transferred cells home to solid tumors. Adhesive ligand-receptor interactions have been
Externí odkaz:
https://doaj.org/article/b4f20bae16a84fccbccc5487a170cc42
Autor:
Guillermo O. Rangel Rivera, Hannah M. Knochelmann, Connor J. Dwyer, Aubrey S. Smith, Megan M. Wyatt, Amalia M. Rivera-Reyes, Jessica E. Thaxton, Chrystal M. Paulos
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing T cells of these nutrients to function and thrive. T cells are often
Externí odkaz:
https://doaj.org/article/b97a96fc05df4b82bb16cd5baaca35a4
Autor:
Stefanie R. Bailey, Michelle H. Nelson, Kinga Majchrzak, Jacob S. Bowers, Megan M. Wyatt, Aubrey S. Smith, Lillian R. Neal, Keisuke Shirai, Carmine Carpenito, Carl H. June, Michael J. Zilliox, Chrystal M. Paulos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The role of human CD4+ T cell subsets in cancer immunotherapy is still unclear. Here, the authors show that CD26 identifies three CD4+ T cell subsets with distinct immunological properties in both healthy individuals and cancer patients.
Externí odkaz:
https://doaj.org/article/63f1a5f94c67463f9202a2a71250b8b7
Autor:
Connor J. Dwyer, Hannah M. Knochelmann, Aubrey S. Smith, Megan M. Wyatt, Guillermo O. Rangel Rivera, Dimitrios C. Arhontoulis, Eric Bartee, Zihai Li, Mark P. Rubinstein, Chrystal M. Paulos
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Adoptive T cell transfer therapy (ACT) using tumor infiltrating lymphocytes or lymphocytes redirected with antigen receptors (CAR or TCR) has revolutionized the field of cancer immunotherapy. Although CAR T cell therapy mediates robust responses in p
Externí odkaz:
https://doaj.org/article/825995c99c0a4d7983aee31e01cf63b3
Autor:
Hannah M. Knochelmann, Aubrey S. Smith, Connor J. Dwyer, Megan M. Wyatt, Shikhar Mehrotra, Chrystal M. Paulos
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Genetic redirection of T lymphocytes with chimeric antigen receptors (CARs) has soared from treating cancers preclinically to FDA approval for hematologic malignancies and commercial-grade production scale in under 30 years. To date, solid tumors are
Externí odkaz:
https://doaj.org/article/229323c4814e4454ae5f589352312db2
Autor:
Jacob S. Bowers, Kinga Majchrzak, Michelle H. Nelson, Bulent Arman Aksoy, Megan M. Wyatt, Aubrey S. Smith, Stefanie R. Bailey, Lillian R. Neal, Jeffrey E. Hammerbacher, Chrystal M. Paulos
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about
Externí odkaz:
https://doaj.org/article/692b7233642b4e4695b1d1a1960096eb
Autor:
Megan M. Wyatt, Logan W. Huff, Michelle H. Nelson, Lillian R. Neal, Andrew R. Medvec, Guillermo O. Rangel Rivera, Aubrey S. Smith, Amalia M. Rivera Reyes, Hannah M. Knochelmann, James L. Riley, Gregory B. Lesinski, Chrystal M. Paulos
Publikováno v:
Molecular Therapy.
Autor:
Chrystal M. Paulos, Zihai Li, Mark P. Rubinstein, Gregory B. Lesinski, Kent Armeson, Carsten Krieg, Joshua D. Horton, Guillermo O. Rangel Rivera, Michelle H. Nelson, Megan M. Wyatt, Jacob S. Bowers, Aubrey S. Smith, Connor J. Dwyer, Hannah M. Knochelmann
The accessibility of adoptive T-cell transfer therapies (ACT) is hindered by the cost and time required for product development. Here we describe a streamlined ACT protocol using Th17 cells expanded only 4 days ex vivo. While shortening expansion com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865d6c8085a5b65b13a98a477eaf0cac
https://doi.org/10.1158/0008-5472.c.6511728.v1
https://doi.org/10.1158/0008-5472.c.6511728.v1
Autor:
Guillermo O. Rangel Rivera, Connor J. Dwyer, Hannah M. Knochelmann, Aubrey S. Smith, Arman Aksoy, Anna C. Cole, Megan M. Wyatt, Jessica E. Thaxton, Gregory B. Lesinski, Chrystal M. Paulos
Publikováno v:
bioRxiv
Generating stem memory T cells (TSCM) is a key goal for improving cancer immunotherapy. Yet, the optimal way to modulate signaling pathways that enrich TSCMproperties remains elusive. Here, we discovered that the degree to which the PI3Kδ pathway is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd58a1c8f9d202cd1ea6fdde4821d16
https://europepmc.org/articles/PMC10028919/
https://europepmc.org/articles/PMC10028919/
Autor:
Megan M. Wyatt, Logan W. Huff, Michelle H. Nelson, Lillian R. Neal, Andrew R. Medvec, Guillermo O. Rangel Rivera, Aubrey S. Smith, Amalia M. Rivera Reyes, Hannah M. Knochelmann, James L. Riley, Gregory B. Lesinski, Chrystal M. Paulos
Adoptive cell transfer (ACT) therapy with IL-17 producing human T cells elicits potent antitumor activity in preclinical models. However, further refinement of this novel approach is needed to position it for clinical application. While activation si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cafecac469484781fe6c2b84201acb7
https://doi.org/10.1101/2022.10.28.514057
https://doi.org/10.1101/2022.10.28.514057