Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Aubrey R. Hill"'
Autor:
Leslie E. Orgel, Aubrey R. Hill
Publikováno v:
Origins of Life and Evolution of the Biosphere. 32:99-102
Adenine is formed in about 18% yield whenHCN tetramer is heated with ammonium formate at 110 °C. Theprebiotic significance of this reaction is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aac3c0ebd86e291908ee9205af1b3ec5
https://doi.org/10.1023/a:1016070723772
https://doi.org/10.1023/a:1016070723772
Autor:
Aubrey R. Hill, Leslie E. Orgel
Publikováno v:
Origins of Life and Evolution of the Biosphere. 29:115-122
Unlike glutamic acid, L-gamma-carboxyglutamic acid does not oligomerize efficiently when treated with carbonyldiimidazole in aqueous solution. However, divalent ions such as Mg2+ catalyze the reaction, and lead to the formation of oligomers in good y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa9235f3bebcdd72c37884b2cca9d99
https://doi.org/10.1023/a:1006512304332
https://doi.org/10.1023/a:1006512304332
Publikováno v:
Origins of Life and Evolution of the Biosphere. 28:235-243
Oligomers of the negatively-charged amino acids, glutamic acid, aspartic acid, and O-phospho-L-serine are adsorbed by hydroxylapatite and illite with affinities that increase with oligomer length. In the case of oligo-glutamic acids adsorbed on hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2794dd0aa69a39c16e642dae5dae8dd8
https://doi.org/10.1023/a:1006572112311
https://doi.org/10.1023/a:1006572112311
Publikováno v:
Origins of life and evolution of the biosphere. 26:1-5
Treatment of relatively concentrated aqueous solutions of O-phospho-serine (50 mM), aspartic acid (100 mM) or glutamic acid (100 mM) with carbonyldiimidazole leads to the formation of an activated intermediate that oligomerizes efficiently. When the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6e9dd5346144188887039d2e59909f
https://doi.org/10.1007/bf01808155
https://doi.org/10.1007/bf01808155
Autor:
Leslie E. Orgel, Aubrey R. Hill
Publikováno v:
Bioconjugate Chemistry. 2:431-434
Photooxidation and consequent cleavage of oligodeoxynucleotides by the uranyl ion is greatly enhanced in the presence of a terminal 5'- or 3'-phosphate group. This enhanced cleavage is confined to nearby phosphodiester bonds in the case of a 5'-phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ffedb532bbdec59a1fbded841343d7c
https://doi.org/10.1021/bc00012a009
https://doi.org/10.1021/bc00012a009
Autor:
Aubrey R. Hill, Leslie E. Orgel
Publikováno v:
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 26(6)
The carbonyldiimidazole-induced oligomerizations of aspartic acid, glutamic acid and O-phospho-serine are amongst the most efficient reported syntheses of biopolymers in aqueous solution. The dependence of the yields of products on the concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4132de5cf76741cb609583d43534c1
https://pubmed.ncbi.nlm.nih.gov/11536772
https://pubmed.ncbi.nlm.nih.gov/11536772
Publikováno v:
Nature. 381(6577)
Most theories of the origin of biological organization assume that polymers with lengths in the range of 30-60 monomers are needed to make a genetic system viable. But it has not proved possible to synthesize plausibly prebiotic polymers this long by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eced7520bc532b9eafb13866685fdf
https://pubmed.ncbi.nlm.nih.gov/8609978
https://pubmed.ncbi.nlm.nih.gov/8609978
Publikováno v:
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 23(5-6)
In earlier work we have shown that C-rich templates containing isolated A, T or G residues and short oligo(G) sequences can be copied effectively using nucleoside-5'-phosphoro(2-methyl)imidazolides as substrates. We now show that isolated A or T resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7786b6349c03eb2f0ce120f45b55ce31
https://pubmed.ncbi.nlm.nih.gov/8115162
https://pubmed.ncbi.nlm.nih.gov/8115162
Publikováno v:
Journal of molecular evolution. 32(6)
We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5′-phosphate (2) and 3-isoxanthosine 5′-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdba7e1f480bb6a653d01835c91f5d94
https://pubmed.ncbi.nlm.nih.gov/1651397
https://pubmed.ncbi.nlm.nih.gov/1651397
Publikováno v:
Journal of Molecular Evolution. 27:91-95
Template-directed oligomerization of an activated derivative of 3-isoadenosine 5'-phosphate (piA) on polyuridylic acid [poly(U)] was studied. The reaction of ImpiA is more efficient than the corresponding reaction of ImpA, and produces 3'-5'-linked o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c235404bdd207c1bacb2aedd527b95a
https://doi.org/10.1007/bf02138366
https://doi.org/10.1007/bf02138366