Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Aubrey M Schonhoff"'
Autor:
Gregory P. Williams, Aubrey M. Schonhoff, Asta Jurkuvenaite, Aaron D. Thome, David G. Standaert, Ashley S. Harms
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Background Parkinson’s disease (PD) is characterized by intracellular alpha-synuclein (α-syn) inclusions, progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and activation of the innate and adaptive im
Externí odkaz:
https://doaj.org/article/272314d6c741462b81a2af6fd89ea48f
Publikováno v:
Journal of Parkinson's Disease. 12:S129-S136
Inflammation has increasingly become a focus of study in regards to Parkinson’s disease (PD). Moreover, both central and peripheral sources of inflammation have been implicated in the pathogenesis of PD. Central inflammation consisting of activated
Publikováno v:
Nature. 603:38-40
CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease
Autor:
Asta Jurkuvenaite, Nicole J Gallups, David G. Standaert, Aubrey M Schonhoff, Ashley S. Harms, Gregory P. Williams
Publikováno v:
Brain
α-Synuclein, a key pathological component of Parkinson's disease, has been implicated in the activation of the innate and adaptive immune system. This immune activation includes microgliosis, increased inflammatory cytokines, and the infiltration of
Autor:
Ashley S. Harms, Woong-Jai Won, David G. Standaert, David J. Marmion, Jeffrey H. Kordower, Asta Jurkuvenaite, Gregory P. Williams, Aubrey M Schonhoff
Publikováno v:
Acta Neuropathologica
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by abnormal accumulation of alpha-synuclein (α-syn) in oligodendrocytes accompanied by inflammation, demyelination, and subsequent synapse and neuronal loss. Lit
Publikováno v:
Curr Opin Immunol
The intestinal microbiome influences neuroinflammatory disease in animal models, and recent studies have identified multiple pathways of communication between the gut and brain. Microbes are able to produce metabolites that enter circulation, can alt
Autor:
Hisham Abdelmotilib, Enquan Xu, Ashley S. Harms, Zhiyong Liu, Arpine Sokratian, Kaela Kelly, Michael G. Schlossmacher, Sidhanth Chandra, Irene E. Harmsen, Aubrey M Schonhoff, Nicole Bryant, Andrew B. West, Ravindra Boddu, Valentina Krendelshchikova
Missense mutations in the LRRK2 gene that lead to LRRK2 kinase hyperactivity can cause Parkinson’s disease (PD). The link between LRRK2 and α-synuclein aggregation in PD remains enigmatic. Numerous reports suggest critical LRRK2 functions in micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80dd4f8f030fd031669163912f7c261
https://doi.org/10.1101/2020.05.04.077065
https://doi.org/10.1101/2020.05.04.077065
Autor:
Aubrey M Schonhoff, Ashley S. Harms, Gregory P. Williams, Zachary D. Wallen, David G. Standaert
Parkinson’s disease (PD) has classically been defined as a movement disorder, in which motor symptoms are explained by the aggregation of alpha-synuclein (α-syn) and subsequent death of dopaminergic neurons of the substantia nigra pars compacta (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2612f1fe0ce2afa808f3dd338a2ab67
https://doi.org/10.1016/bs.pbr.2019.10.006
https://doi.org/10.1016/bs.pbr.2019.10.006
Autor:
Aubrey M. Schonhoff, Geoffrey B. Maddox, Jessica D. Gatewood, Mary A. Pyc, Zachary S. Kauffman
Publikováno v:
Memory & Cognition. 46:1376-1388
Although substantial evidence indicates that spacing repeated study events with intervening material generally enhances memory performance relative to massing study events, the mechanism underlying this benefit is less clear. Two experiments examined
Autor:
Aaron D. Thome, David G. Standaert, Xinru Li, Ashley S. Harms, Hongwei Qin, Aubrey M Schonhoff, Zhaoqi Yan, Yudong Liu, Gregory P. Williams, Etty N. Benveniste
Accumulation of alpha-synuclein (α-syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate immune system, production of inflammatory cytokines and chemokines, and subsequent neurode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc1b324e69a08e36a4f8a63129751e1
https://europepmc.org/articles/PMC5759972/
https://europepmc.org/articles/PMC5759972/