Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Aubart, Kelly M."'
Autor:
Spletstoser, Jared T., Dreabit, Jason, Knox, Andrew N., Benowitz, Andrew, Campobasso, Nino, Ward, Paris, Cui, Guanglei, Lewandowski, Thomas, McCloskey, Lynn, Aubart, Kelly M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 August 2019 29(16):2410-2414
Autor:
Steven J. Novick, Peter DeMarsh, Jennifer Hoover, Robert J. Straub, Thomas Lewandowski, Aubart Kelly M, Stephen Rittenhouse, Magdalena Zalacain
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:180-189
GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. We have characterized the in vivo pharmacodynamics (PD) of GSK1322322 in immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7517661bab19abfab57bcf7bcbfc90a
https://doi.org/10.1128/aac.01842-15
https://doi.org/10.1128/aac.01842-15
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:707-710
GSK1322322, a novel peptide deformylase inhibitor currently in development as an oral and intravenous agent for the treatment of hospitalized community-acquired bacterial pneumonia, showed poor in vitro activity against a panel of 50 Legionella pneum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbe7d26938affbd7ced50e1f771ddb0
https://doi.org/10.1128/aac.04006-14
https://doi.org/10.1128/aac.04006-14
Autor:
Aubart Kelly M, Karen O'Dwyer, Dongzhao Chen, Thomas Lewandowski, Magdalena Zalacain, D. L. Butler
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:290-296
Peptide deformylase (PDF), a clinically unexploited antibacterial target, plays an essential role in protein maturation. PDF inhibitors, therefore, represent a new antibiotic class with a unique mode of action that provides an alternative therapy for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb52a083395b0bc2cf01a74328e0650c
https://doi.org/10.1128/aac.01292-13
https://doi.org/10.1128/aac.01292-13
Autor:
Lori S. Jones, Elizabeth Thomas, Ganesh M. Sathe, Karen A. Ingraham, James R. Brown, Seda Arat, Stephanie Van Horn, Odin J. Naderer, Christopher M. Traini, David J. Holmes, Aubart Kelly M, Aaron Spivak, George P. Livi
GSK1322322 is a novel antibacterial agent under development, and it has known antibacterial activities against multidrug-resistant respiratory and skin pathogens through its inhibition of the bacterial peptide deformylase. Here, we used next-generati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502631b051cea56c54e8d41f293ed6ef
https://europepmc.org/articles/PMC4335841/
https://europepmc.org/articles/PMC4335841/
Autor:
Chantal M. Petit, Magdalena Zalacain, Glenn S. Van Aller, Chad Quinn, Ravi Nandigama, Walt E. Dewolf, Robert A. Copeland, Zhihong Lai, Siegfried B. Christensen, Aubart Kelly M
Publikováno v:
Biochemistry. 44:253-260
Polypeptide deformylase (PDF) is an essential bacterial metalloenzyme responsible for the removal of the N-formyl group from the N-terminal methionine of nascent polypeptides. Inhibition of bacterial PDF enzymes by actinonin, a naturally occurring an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5c82e5b4944b23d2f516c9a6ec6b10
https://doi.org/10.1021/bi048632b
https://doi.org/10.1021/bi048632b
Autor:
Ceri J. Lewis, Kathrine J. Smith, Jo J. Jones, Andrew P. Fosberry, Siegfried B. Christensen, Aubart Kelly M, Michael Lonetto, Edward McManus, Chantal M. Petit, Martin G. Smyth
Publikováno v:
Protein Science. 12:349-360
Polypeptide deformylase (PDF) catalyzes the deformylation of polypeptide chains in bacteria. It is essential for bacterial cell viability and is a potential antibacterial drug target. Here, we report the crystal structures of polypeptide deformylase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a036efeb824919e395159fee9c7efdf6
https://doi.org/10.1110/ps.0229303
https://doi.org/10.1110/ps.0229303
Autor:
Aubart Kelly M, Clayton H. Heathcock
Publikováno v:
The Journal of Organic Chemistry. 64:16-22
The characteristic spirodienone structure of the discorhabdin alkaloids is readily formed by reaction of the tyramine-substituted indoloquinonimines 26, 35, and 36 with cupric chloride, triethylamine, and oxygen. This cyclization provides a possibly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596df95fbc096c8db5a063511099f91c
https://doi.org/10.1021/jo9815397
https://doi.org/10.1021/jo9815397
Autor:
Frank Fan, Jianzhong Huang, Reannon Holland, Daniel R. Gentry, Shannon Rogers, Thomas Lewandowski, Peter DeMarsh, Magdalena Zalacain, Aubart Kelly M
Inhibitors of peptide deformylase (PDF) represent a new class of antibacterial agents with a novel mechanism of action. Mutations that inactivate formyl methionyl transferase (FMT), the enzyme that formylates initiator methionyl-tRNA, lead to an alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9405bbd0a8dc4030c0b1a36e33c535
https://europepmc.org/articles/PMC3697361/
https://europepmc.org/articles/PMC3697361/
Autor:
Donghui Qin, Meredith Hackel, Aubart Kelly M, Sarah Hightower, Karen O'Dwyer, D. L. Butler, Daryl J. Hoban, Magdalena Zalacain, Samuel K. Bouchillon
Publikováno v:
Antimicrobial agents and chemotherapy. 57(5)
GSK1322322 is a novel peptide deformylase (PDF) inhibitor being developed for the intravenous and oral treatment of acute bacterial skin and skin structure infections and hospitalized patients with community-acquired pneumonia. The activity of GSK132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8300a25112804e5df4b65dbce6152429
https://pubmed.ncbi.nlm.nih.gov/23478958
https://pubmed.ncbi.nlm.nih.gov/23478958