Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells

Autor: Aušra Nemeikaitė-Čėnienė, Per Haberkant, Dalius Kučiauskas, Frank Stein, Narimantas Čėnas

Publikováno v: International journal of molecular sciences, Basel : MDPI, 2023, vol. 24, iss. 7, art. no. 6863, p. [1-13]

3-Amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ) and other heteroaromatic N-oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities. Their action is attributed to the enzymatic single-electron reduction to free ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a64700370d1c1da80225101bb6c5f8
https://doi.org/10.3390/ijms24076863

5Flavoenzyme-catalyzed single-electron reduction of nitroaromatic antiandrogens: implications for their cytotoxicity

Autor: Aušra, Nemeikaitė-Čėnienė, Audronė, Marozienė, Lina, Misevičienė, Jelena, Tamulienė, Aliaksei V, Yantsevich, Narimantas, Čėnas

Publikováno v: Free radical research. 55(3)

The therapeutic action of nitroaromatic antiandrogens nilutamide and flutamide may be complicated by their cytotoxicity, whose mechanisms are still incomprehensively understood. In particular this concerns the enzymatic redox cycling of flutamide and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0ab4f9c91c75d89c7108dfed15a4862
https://pubmed.ncbi.nlm.nih.gov/34098820

The use of rate constants of flavoenzyme-catalyzed single-electron reduction of nitroaromatics in the analysis of their cytotoxicity mechanisms

Autor: Aušra Nemeikaitė-Čėnienė, Violeta Jonušienė, Audronė Marozienė, Narimantas Čėnas, Lina Misevičienė

Publikováno v: Book of Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::366ef8829d3b06b191ae6a3ff7ba9876
https://doi.org/10.21175/rad.abstr.book.2021.1.5

The effect of Saccharomyces cerevisiae β-glucan on proliferation, phagocytosis and cytokine production of murine macrophages and dendritic cells

Autor: Artur Javmen, Mykolas Mauricas, Aušra Nemeikaitė-Čėnienė, Saulius Grigiškis, Almantas Siaurys, Irena Jonauskienė, Jelena Lysovienė

Publikováno v: Biologia. 72:561-568

β-Glucan is a natural carbohydrate, which is produced by the variety of different organisms - bacteria, fungi, plants, etc. β-Glucan from different sources has been recognized as an active material, which is an immune stimulator for plants, inverte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f46972f59c683ee54a9689fd342a8cf
https://doi.org/10.1515/biolog-2017-0063

Kinetics of flavoenzyme-catalyzed reduction of tirapazamine derivatives: implications for their prooxidant cytotoxicity

Autor: Narimantas Čėnas, Violeta Jonušienė, Lina Misevičienė, A. V. Yantsevich, Aušra Nemeikaitė-Čėnienė, Audronė Marozienė, Jonas Šarlauskas

Publikováno v: International journal of molecular sciences: Special issue: Bioreductive activation/detoxification of prooxidant xenobiotics and drugs, Basel : MDPI, 2019, vol. 20, no. 18, p. 4602-4616
International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4602 (2019)

Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN&rarr
O) exhibit promising antibacterial, antiprotozoal, and tumoricidal activities. Their action is typically attributed to bioreductive activation and free radical generation. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea22ff7141a2128b1d6ed5cb463bad9
https://repository.vu.lt/VU:ELABAPDB49008306&prefLang=en_US