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A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

Autor: Solomon, Daniel A, Stepto, Alan, Au, Wing Hei, Adachi, Yoshitsugu, Diaper, Danielle C, Hall, Rachel, Rekhi, Anjeet, Boudi, Adel, Tziortzouda, Paraskevi, Lee, Youn-Bok, Smith, Bradley, Bridi, Jessika C, Spinelli, Greta, Dearlove, Jonah, Humphrey, Dickon M, Gallo, Jean-Marc, Troakes, Claire, Fanto, Manolis, Soller, Matthias, Rogelj, Boris, Parsons, Richard B, Shaw, Christopher E, Hortobágyi, Tibor, Hirth, Frank

Publikováno v: Brain
Solomon, D A, Stepto, A, Au, W H, Adachi, Y, Diaper, D C, Hall, R, Rekhi, A, Boudi, A, Tziortzouda, P, Lee, Y B, Smith, B, Bridi, J C, Spinelli, G, Dearlove, J, Humphrey, D M, Gallo, J M, Troakes, C, Fanto, M, Soller, M, Rogelj, B, Parsons, R B, Shaw, C E, Hortobágyi, T & Hirth, F 2018, ' A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration ', Brain, vol. 141, no. 10, pp. 2908-2924 . https://doi.org/10.1093/brain/awy241

TDP-43 accumulation is a major pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia, including the most common genetic cause, G4C2 hexanucleotide repeat expansion in C9ORF72 (C9ALS/FTD). Solomon et al. report that G4C2-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9681af046610bf556fdeaefa7ddc781f
http://europepmc.org/articles/PMC6158706