Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Atze T. Das"'
Autor:
Lise Sarah Namer, Alex Harwig, Stephan P. Heynen, Atze T. Das, Ben Berkhout, Raymond Kaempfer
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background Activation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation factor 2 α-chain (eIF2α) phosphorylation, attenuating thereby translation. We report that this RNA-mediated ne
Externí odkaz:
https://doaj.org/article/a21711e43d92478496d8b395fce71a1b
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-5 (2019)
Abstract Antiretroviral therapy (ART) can effectively suppress ongoing HIV replication and block disease progression, but the infection is never cured due to the persistence of a small pool of latently infected cells hosting integrated replication-co
Externí odkaz:
https://doaj.org/article/017b226a9f99482eb6989cad37ab1b27
Autor:
Jianbo Chen, Chijioke Umunnakwe, David Q. Sun, Olga A. Nikolaitchik, Vinay K. Pathak, Ben Berkhout, Atze T. Das, Wei-Shau Hu
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm
Externí odkaz:
https://doaj.org/article/53d14a27b1f2424e90ed3ce0e814c419
Publikováno v:
Viruses, Vol 13, Iss 12, p 2461 (2021)
Novel therapeutic strategies aiming at the permanent inactivation of the HIV-1 reservoir in infected individuals are currently being explored, including approaches based on CRISPR-Cas gene editing. Extinction of all infectious HIV provirus in infecte
Externí odkaz:
https://doaj.org/article/3b5585ef5a79455d909b0343ed011dbe
Variations in the Abortive HIV-1 RNA Hairpin Do Not Impede Viral Sensing and Innate Immune Responses
Publikováno v:
Pathogens, Vol 10, Iss 7, p 897 (2021)
The highly conserved trans-acting response element (TAR) present in the RNA genome of human immunodeficiency virus 1 (HIV-1) is a stably folded hairpin structure involved in viral replication. However, TAR is also sensed by viral sensors, leading to
Externí odkaz:
https://doaj.org/article/46aed72068c1448aa89f958d4a19693d
Publikováno v:
Viruses, Vol 12, Iss 3, p 330 (2020)
Although several studies demonstrated that the HIV proviral DNA can be effectively targeted and inactivated by the CRISPR-Cas9 system, the precise inactivation mechanism has not yet been analyzed. Whereas some studies suggested efficient proviral DNA
Externí odkaz:
https://doaj.org/article/6d10f3c6947f44d4a02885039ba25bdf
Autor:
Atze T. Das, Ben Berkhout
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
Externí odkaz:
https://doaj.org/article/5249d4cc572041f29da68a6b8d52afba
Autor:
Gilles Darcis, Caroline S. Binda, Bep Klaver, Elena Herrera-Carrillo, Ben Berkhout, Atze T. Das
Publikováno v:
Viruses, Vol 11, Iss 3, p 255 (2019)
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system is widely explored for sequence-specific attack on HIV-1 proviral DNA. We recently identified dual-guide RNA (dual-gRNA) combinations that can block HIV-1 replication
Externí odkaz:
https://doaj.org/article/788671ff50074f01a547c5be11301ada
Publikováno v:
Viruses, Vol 10, Iss 4, p 157 (2018)
Jan Svoboda studied aspects of viral latency, in particular with respect to disease induction by avian RNA tumor viruses, which were later renamed as part of the extended retrovirus family. The course of retroviral pathogenesis is intrinsically linke
Externí odkaz:
https://doaj.org/article/b8510bdf599c4e78b9a2d986f91512ab
Publikováno v:
Viruses, Vol 8, Iss 7, p 200 (2016)
RNA splicing is a critical step in the human immunodeficiency virus type 1 (HIV-1) replication cycle because it controls the expression of the complex viral proteome. The major 5′ splice site (5′ss) that is positioned in the untranslated leader o
Externí odkaz:
https://doaj.org/article/f427521b4a84486a846aa67c5658dfa8