aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1

Autor: Yan Liu, Jianming Wang, Li Tian, Jian Zhang, Xiangyu Li, Yun Lu, Wei Yao, Lei Xu, Zhengdong Deng, Tao Yang, Chaoqun Ma

Publikováno v: Redox Biology
Redox Biology, Vol 22, Iss, Pp-(2019)

Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis characterized by its insensitivity to chemotherapy. Emerging evidence indicates that cytoprotective antioxidation is involved in drug resistance of various cancers; h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6426c199ffadd37527b859b3842596e
https://pubmed.ncbi.nlm.nih.gov/30822690

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Atypical protein kinase Cι as a human oncogene and therapeutic target.

Autor: Parker PJ; London Research Institute, Lincoln's Inn Fields, London WC2A 3LY, UK; King's College London, Guy's Campus, London, UK., Justilien V; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 45400 San Pablo Road, Jacksonville, FL 32224, USA., Riou P; London Research Institute, Lincoln's Inn Fields, London WC2A 3LY, UK., Linch M; London Research Institute, Lincoln's Inn Fields, London WC2A 3LY, UK; Royal Marsden Hospital, Fulham Road, London, UK., Fields AP; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 45400 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address: Fields.Alan@mayo.edu.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2014 Mar 01; Vol. 88 (1), pp. 1-11. Date of Electronic Publication: 2013 Nov 11.