Výsledky vyhledávání - "Atushi Kozaki"

Synthesis of base-modified noraristeromycin derivatives and their inhibitory activity against human and Plasmodium falciparum recombinant S-adenosyl-l-homocysteine hydrolase

Autor: Yukio Kitade, Toshihiro Miwa, Masayuki Nakanishi, Atushi Kozaki

Publikováno v: Tetrahedron. 58:1271-1277

Noraristeromycin derivatives possessing 2- or 8-position modified adenine or 8-aza-7-deazaadenine were synthesized, and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolases was investigated. Amo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23f60def5afe14fe6049f09912e86d6e
https://doi.org/10.1016/s0040-4020(01)01247-9

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Facile synthesis of 9-[(1′R,2′S)-2′-hydroxy-3′-oxocyclopentan-1′-yl]-9-H-adenine possessing inhibitory activity against human recombinant S-adenosyl-l-homocysteine hydrolase

Autor: Chizuko Yatome, Atushi Kozaki, Yukio Kitade

Publikováno v: Tetrahedron Letters. 42:433-435

Treatment of 4′- O -methanesulfonyl-2′,3′- O -isopropylidenenoraristeromycin with KOBu t gave the corresponding 3′,4′-dehydro derivative, and subsequent deprotection resulted in the formation of 9-[(1′ R ,2′ S )-2′-hydroxy-3′-oxocyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::024ad61f1d6b633b77df09b25257591e
https://doi.org/10.1016/s0040-4039(00)01978-x

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ChemInform Abstract: Facile Method for the Preparation of 7-Methyl-8-oxoguanosine as an Immunomodulator

Autor: Y. Takeda, Kensuke Takahashi, Atushi Kozaki, Kazuo Hirota, N. Saito, Chizuko Yatome, Yukio Kitade, H. Sajiki

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3616ac72f80c8a2ec83e45ea8eb5f562
https://doi.org/10.1002/chin.199827278

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Synthesis of S-adenosyl-L-homocysteine hydrolase inhibitors and their biological activities

Autor: Atushi Kozaki, Chizuko Yatome, Yukio Kitade, Toshihiro Miwa, Masayuki Nakanishi, Toshihiko Gotoh

Publikováno v: Nucleic acids symposium series. (42)

Several nucleosides have been prepared as a possible inhibitor of human S-adenosyl-L-homocysteine (SAH) hydrolase for the development of anti-viral agents. Recently, SAH hydrolase has been considered as an attractive target for parasite chemotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22332a5075dbd94a7aa3dc5c52e2052
https://pubmed.ncbi.nlm.nih.gov/10780361

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Synthesis of carbocyclic nucleosides as potential antiviral agents

Autor: Yukio Kitade, Yoshihito Ueno, Atushi Kozaki, Fazila Zulfiqar

Publikováno v: Nucleic Acids Symposium Series. 1:59-60

Treatment of 1-[(1'R,2'S,3'S,4'S)-4'-methanesulfonyl-2',3'-O- isopropylidenedioxycyclopentan-1'-yl]-1-H-uracil with LiN3 gave 1-[(1'R,2'S,3'R)-2',3'-O-isopropylidenedioxy-4'- cyclopenten-1'-yl]-1-H-uracil. When KOBut was added instead of LiN3, 1-[(1'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d1c11a4696063ac2993eede07a314a
https://doi.org/10.1093/nass/1.1.59

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Synthesis of carbocyclic nucleosides and their SAH hydrolase inhibitory activities

Autor: Chizuko Yatome, Masayuki Nakanishi, Toshihiro Miwa, Atushi Kozaki, Yukio Kitade

Publikováno v: Nucleic Acids Symposium Series. 44:111-112

The cellular enzyme S-adenosyl-L-homocysteine (SAH) hydrolase has emerged as a target enzyme for the molecular design of anti-viral agents.1 Recently, SAH hydrolase has been considered as an attractive target in parasite chemotherapy for malaria. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60dd6171cc74da861573f48fc7e67046
https://doi.org/10.1093/nass/44.1.111

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