Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Atul Rangadurai"'
Autor:
Bei Liu, Honglue Shi, Atul Rangadurai, Felix Nussbaumer, Chia-Chieh Chu, Kevin Andreas Erharter, David A. Case, Christoph Kreutz, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
m6A RNA post-transcriptional modification changes RNA hybridization kinetics. Here the authors show that the methylamino group can adopt syn-conformation pairing with uridine with a mismatch-like conformation in RNA duplex. They also develop a quanti
Externí odkaz:
https://doaj.org/article/82625506d090481bad2beca7aff5481e
Autor:
Honglue Shi, Atul Rangadurai, Hala Abou Assi, Rohit Roy, David A. Case, Daniel Herschlag, Joseph D. Yesselman, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Determining dynamic ensembles of biomolecules is still challenging. Here the authors present an approach for rapid RNA ensemble determination that combines RNA structure prediction tools and NMR residual dipolar coupling data and use it to determine
Externí odkaz:
https://doaj.org/article/6aa8fe55c63a47b68b968427d832dae8
Autor:
Rhese Thompson, Derek Carbaugh, Joshua Nielsen, Ciara Witt, Rita Meganck, Atul Rangadurai, Bo Zhao, Jeffrey Bonin, Nathan Nicely, William Marzluff, Aaron Frank, Helen Lazear, Qi Zhang
Biomolecules continually sample alternative conformations. Consequently, even the most energetically favored ground conformational state has a finite lifetime. Here, we show that, in addition to the 3D structure, the lifetime of a ground conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a9bc7a269dee4ab11e8d2994cbbea3e
https://doi.org/10.21203/rs.3.rs-2879957/v1
https://doi.org/10.21203/rs.3.rs-2879957/v1
Publikováno v:
Magnetic Resonance. 2:715-731
In duplex DNA, Watson–Crick A–T and G–C base pairs (bp's) exist in dynamic equilibrium with an alternative Hoogsteen conformation, which is low in abundance and short-lived. Measuring how the Hoogsteen dynamics varies across different DNA seque
Autor:
Stephanie Gu, Eric Szymanski, Atul Rangadurai, Honglue Shi, Bei Liu, Akanksha Manghrani, Hashim Al-Hashimi
Replicative errors contribute to the genetic diversity needed for evolution but in high frequency can lead to genomic instability. The mechanisms determining the frequency of DNA copying errors are not fully understood. Here, we show DNA dynamics det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bb2dac6440f6e23a0da83d3943d230
https://doi.org/10.21203/rs.3.rs-1979339/v1
https://doi.org/10.21203/rs.3.rs-1979339/v1
Autor:
Robert J. Fick, Christoph Kreutz, Steve Scheiner, Yu Xu, Atul Rangadurai, Allison L. Stelling, Honglue Shi, Roger D. Sommer, Felix Nussbaumer, Amy Y. Liu
Publikováno v:
The Journal of Physical Chemistry. B
Measuring the strength of the hydrogen bonds between DNA base pairs is of vital importance for understanding how our genetic code is physically accessed and recognized in cells, particularly during replication and transcription. Therefore, it is impo
Autor:
Atul Rangadurai, Honglue Shi, Yu Xu, Bei Liu, Hala Abou Assi, John D. Boom, Huiqing Zhou, Isaac J. Kimsey, Hashim M. Al-Hashimi
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Thermodynamic preferences to form non-native conformations are crucial for understanding how nucleic acids fold and function. However, they are difficult to measure experimentally because this requires accurately determining the population of minor l
Autor:
Rohit Roy, Honglue Shi, Atul Rangadurai, Hashim M. Al-Hashimi, Hala Abou Assi, David A. Case, Daniel Herschlag, Joseph D. Yesselman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Biomolecules form dynamic ensembles of many inter-converting conformations which are key for understanding how they fold and function. However, determining ensembles is challenging because the information required to specify atomic structures for tho
Publikováno v:
Journal of Biomolecular NMR. 74:457-471
NMR off-resonance R1ρ relaxation dispersion measurements on base carbon and nitrogen nuclei have revealed that wobble G·T/U mismatches in DNA and RNA duplexes exist in dynamic equilibrium with short-lived, low-abundance, and mutagenic Watson–Cric
Autor:
Felix Nussbaumer, Christoph Kreutz, David A. Case, Atul Rangadurai, Kevin Erharter, Honglue Shi, Hashim M. Al-Hashimi, Bei Liu, Chia Chieh Chu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
N6-methyladenosine (m6A) is a post-transcriptional modification that controls gene expression by recruiting proteins to RNA sites. The modification also slows biochemical processes through mechanisms that are not understood. Using temperature-depende