Microneedle-assisted transdermal delivery of Zolmitriptan: effect of microneedle geometry, in vitro permeation experiments, scaling analyses and numerical simulations

Autor: Karthik J. Nair, Diganta Bhusan Das, Chandra Teja Uppuluri, Jyothirmayee Devineni, Atul Nayak, Benjamin R. Whiteside, Tao Han, Buchi N. Nalluri

Publikováno v: Drug Development and Industrial Pharmacy. 43:1292-1303

The present study was aimed to investigate the effect of salient microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of Zolmitriptan (ZMT).Two types of MN devices viz. AdminPatchMicro-inject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c71509da0a9f00a7b9f4720b80e87d2
https://doi.org/10.1080/03639045.2017.1313862

Spreading of a Lidocaine Formulation on Microneedle-Treated Skin

Autor: Diganta Bhusan Das, Tzu-Chieh Chao, Atul Nayak, Victor Starov

Publikováno v: Journal of Pharmaceutical Sciences. 104:4109-4116

The spreadability of a liquid drug formulation on skin is an indication of it either remaining stationary or distributing (spreading) as a droplet. Factors determining droplet spreadability of the formulation are spreading area, diameter of the dropl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cecd4d9a307d532c0c411acdbacfed
https://doi.org/10.1002/jps.24625

Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles

Autor: Ololade Olatunji, Pangkhi Medhi, Chandra Teja Uppuluri, Diganta Bhusan Das, Buchi N. Nalluri, Richard T. Olsson, Atul Nayak

Publikováno v: AAPS PharmSciTech. 18(5)

Microneedle (MN) technology has emerged as an effective drug delivery system, and it has tremendous potential as a patient friendly substitute for conventional methods for transdermal drug delivery (TDD). In this paper, we report on the preparation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656f3f43f17bf7db11050ffbde4b6cfe
https://pubmed.ncbi.nlm.nih.gov/28353171

Future Perspectives

Autor: Ololade Olatunji, Géraldine Savary, Michel Grisel, Céline Picard, Atul Nayak

Publikováno v: Natural Polymers ISBN: 9783319264127
Natural Polymers Industry Techniques and Applications
Ololade Olatunji. Natural Polymers Industry Techniques and Applications, Springer International Publishing, pp.363-367, 2015, 9783319264141; 9783319264127. ⟨10.1007/978-3-319-26414-1_12⟩

International audience; In this chapter, we look at the current trends and challenges in natural polymers in industry and give some perspectives for the future. We look at the technologies in development with regards to natural polymers’ applicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7670da97bf1d79097170b104b76118
https://doi.org/10.1007/978-3-319-26414-1_12

Lidocaine permeation from a lidocaine NaCMC/gel microgel formulation in microneedle-pierced skin: vertical (depth averaged) and horizontal permeation profiles

Autor: Atul Nayak, Diganta Bhusan Das, Liam Short

Publikováno v: Drug delivery and translational research. 5(4)

Common local anaesthetics such as lidocaine are administered by the hypodermic parenteral route but it causes pain or anxiety to patients. Alternatively, an ointment formulation may be applied which involves a slow drug diffusion process. In addressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad372c6806bdcdd8fe7e490a2a2cf670
https://pubmed.ncbi.nlm.nih.gov/25895729