Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Atul Bhattaram"'
Autor:
Shailly Mehrotra, Atul Bhattaram, Kevin Krudys, Michael Bewernitz, Ramana Uppoor, Mehul Mehta, Tao Liu, Philip Sheridan, Norman Hershkowitz, Nicholas Kozauer, Eric Bastings, Billy Dunn, Angela Yuxin Men
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:853-863
The US Food and Drug Administration (FDA) has concluded that the efficacy of drugs approved for the treatment of partial onset seizures (POS) in adults can be extrapolated to pediatric patients 1 month of age and above and that independent efficacy t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efcf53ec44dc956f39efc84fc5b8745
https://doi.org/10.1002/cpt.2681
https://doi.org/10.1002/cpt.2681
Autor:
Ruo-Jing, Li, Lian, Ma, Fang, Li, Liang, Li, Youwei, Bi, Ye, Yuan, Yangbing, Li, Yuan, Xu, Xinyuan, Zhang, Jiang, Liu, Venkatesh Atul, Bhattaram, Jie, Wang, Robert, Schuck, Michael, Pacanowski, Hao, Zhu
Publikováno v:
The Journal of Clinical Pharmacology. 62
A rare disease is defined as a condition affecting fewer than 200 000 people in the United States by the Orphan Drug Act. For rare diseases, it is challenging to enroll a large number of patients and obtain all critical information to support drug ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b66e39e548e9b5c02d46d095608148
https://doi.org/10.1002/jcph.2143
https://doi.org/10.1002/jcph.2143
Autor:
Justin C. Earp, Yaning Wang, Fang Li, Yuching Yang, Michael Bewernitz, Jingyu Yu, Xinyuan Zhang, Ruo-Jing Li, Luning Zhuang, Youwei Bi, Jiang Liu, Atul Bhattaram, Lian Ma, Hao Zhu, Jihye Ahn
Publikováno v:
Journal of clinical pharmacologyReferences. 61
Model-informed drug development (MIDD) has been a powerful and efficient tool applied widely in pediatric drug development due to its ability to integrate and leverage existing knowledge from different sources to narrow knowledge gaps. The dose selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c003c2cc904dac61e3e6edc375d0e7
https://pubmed.ncbi.nlm.nih.gov/34185906
https://pubmed.ncbi.nlm.nih.gov/34185906
Autor:
Pangaja Paramsothy, Deborah J. Fox, Kristin M Conway, Gregory Haber, Nicholas E. Johnson, Venkatesh Atul Bhattaram, Swamy Venkatesh, Russell J. Butterfield, Han C Phan, Hobart Rogers, Nicholas Kozauer, Maureen K. Galindo, Natalie Street, Nedra Whitehead, Joyce Oleszek, Xiang Ling, Anindya Roy, Shree Pandya, Dennis J. Matthews, Paul A. Romitti, Katherine A. James, Emma Ciafaloni
Publikováno v:
Muscle Nerve
BACKGROUND Quantifying associations between genetic mutations and loss of ambulation (LoA) among males diagnosed with childhood-onset dystrophinopathy is important for understanding variation in disease progression and may be useful in clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9433c27b5893865213c85fa691110ba
https://pubmed.ncbi.nlm.nih.gov/33150975
https://pubmed.ncbi.nlm.nih.gov/33150975
Autor:
Jiang Liu, Yuching Yang, Lingjue Li, Jingyu Yu, Chao Liu, Yaning Wang, Luning Zhuang, Lian Ma, Hao Zhu, Michael Bewernitz, Atul Bhattaram, Youwei Bi, Ruo-Jing Li, Xinyuan Zhang, Justin C. Earp
Publikováno v:
The Journal of Clinical Pharmacology. 59
The unique challenges in pediatric drug development require efficient and innovative tools. Model-informed drug development (MIDD) offers many powerful tools that have been frequently applied in pediatric drug development. MIDD refers to the applicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2fe40787605a89caec4d8137849d36
https://doi.org/10.1002/jcph.1478
https://doi.org/10.1002/jcph.1478
Autor:
Atul Bhattaram, Venkatesh, Graefe, Ulrike, Kohlert, Claudia, Veit, Markus, Derendorf, Hartmut
Publikováno v:
In Phytomedicine 2002 9 Supplement 3:1-33
Autor:
Davide Burn, Caroline H. Williams-Gray, Lisa J. Bain, Diane Stephenson, Simon Lovestone, Klaus Romero, Maria Isaac, Kieran Breen, Mark Forrest Gordon, Margaret Sutherland, Michele T.M. Hu, Arthur W. Toga, Atul Bhattaram, Donald G. Grosset, Ken Kubota, Yafit Stark, Yoav Ben-Shlomo, Max A. Little, Charles S. Venuto, Enrique Aviles, John Gallacher, Stephen H. Friend, Steve Ford, Ken Marek, Huw R. Morris
Publikováno v:
Journal of Parkinson's Disease
Parkinson’s disease is a complex heterogeneous disorder with urgent need for disease-modifying therapies. Progress in successful therapeutic approaches for PD will require an unprecedented level of collaboration. At a workshop hosted by Parkinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36610cb53b674ecb1e127dd814c99a6
https://doi.org/10.3233/jpd-150570
https://doi.org/10.3233/jpd-150570
Autor:
Sonja Krösser, Hartmut Derendorf, Marco Campioni, Andreas Kovar, Michael Zühlsdorf, Venkatesh Atul Bhattaram
Publikováno v:
The Journal of Clinical Pharmacology. 54:1391-1399
Cilengitideisan avb3/avb5-integrininhibitorinvestigatedasananticanceragent.Thisstudyaimedtodevelopacilengitidepopulationpharmacokinetic model using nonlinear mixed-effects modeling of 136 adult patients with advanced solid tumors and to scale the pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14f313b400a9c6b026779d07f22e558f
https://doi.org/10.1002/jcph.343
https://doi.org/10.1002/jcph.343
Autor:
Jiang Liu, Jeffry Florian, Jee Eun Lee, Atul Bhattaram, Joo Yeon Lee, Nitin Mehrotra, Yeruk Mulugeta, Vikram Sinha, Justin C. Earp, Kevin Krudys, Ping Zhao, Jingyu Yu
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(7)
Dose selection is one of the key decisions made during drug development in pediatrics. There are regulatory initiatives that promote the use of model-based drug development in pediatrics. Pharmacometrics or quantitative clinical pharmacology enables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57bb3d91ce085add3e2624c2162b450
https://pubmed.ncbi.nlm.nih.gov/27079249
https://pubmed.ncbi.nlm.nih.gov/27079249
Autor:
Jeffry Florian, Lauren Neal, Peter Lee, Pravin R. Jadhav, Fang Li, Ying Chen, Yaning Wang, Joga Gobburu, Atul Bhattaram, Christoffer W. Tornoe, Kevin Krudys
Publikováno v:
Expert Review of Clinical Pharmacology. 4:697-703
Knowledge management comprises the strategies and methods employed to generate and leverage knowledge within an organization. This report outlines the activities within the Division of Pharmacometrics at the US FDA to effectively manage knowledge wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1044ae85a2a4ea9a26cc8a96cbd2876
https://doi.org/10.1586/ecp.11.56
https://doi.org/10.1586/ecp.11.56