The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling

Autor: Inmaculada Ruz-Maldonado, Bo Liu, Guo Cai Huang, Patricio Atanes, Shanta J. Persaud, Pratik Choudhary, Attilio Pingitore

Publikováno v: Cellular and Molecular Life Sciences

Aims Endocannabinoids are lipid mediators involved in the regulation of glucose homeostasis. They interact with the canonical cannabinoid receptors CB1 and CB2, and it is now apparent that some cannabinoid receptor ligands are also agonists at GPR55.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa86071809fbf64f532111c8b3f8f3f
http://europepmc.org/articles/PMC7599183

C3aR and C5aR1 act as key regulators of human and mouse β-cell function

Autor: Patricio Atanes, Ross Hawkes, Shanta J. Persaud, Min Zhao, Inmaculada Ruz-Maldonado, Guo Cai Huang, Attilio Pingitore, Bo Liu, Stefan Amisten

Publikováno v: Cellular and Molecular Life Sciences
Atanes, P, Ruz Maldonado, I, Pingitore, A, Hawkes, R, Liu, B, Zhao, M, Huang, G C, Persaud, S J & Amisten, S 2017, ' C3aR and C5aR1 act as key regulators of human and mouse β-cell function ', Cellular and Molecular Life Sciences, pp. 1-12 . https://doi.org/10.1007/s00018-017-2655-1

Aims Complement components 3 and 5 (C3 and C5) play essential roles in the complement system, generating C3a and C5a peptides that are best known as chemotactic and inflammatory factors. In this study we characterised islet expression of C3 and C5 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4992cb95db248dbb972ae3060f4c4916
http://europepmc.org/articles/PMC5769825

Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity

Autor: Inmaculada Ruz-Maldonado, Attilio Pingitore, Bo Liu, Guo Cai Huang, Shanta J. Persaud, Pratik Choudhary

Publikováno v: Pingitore, A, Ruz-Maldonado, I, Liu, B, Huang, G C, Choudhary, P & Persaud, S J 2017, ' Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity ', Cellular Physiology and Biochemistry, vol. 44, no. 4, pp. 1352-1359 . https://doi.org/10.1159/000485532
Cellular Physiology and Biochemistry, Vol 44, Iss 4, Pp 1352-1359 (2017)

Background/Aims: Rodent islets are often used for basic science research but they do not always recapitulate signalling events in human islets. This study evaluated the glucose-dependent responses of human and mouse islets in terms of dynamic insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcae669402eccd4b0ad3c3508e20dd8d
https://doi.org/10.1159/000485532

APT070 (mirococept), a membrane-localizing C3 convertase inhibitor, attenuates early human islet allograft damagein vitroandin vivoin a humanized mouse model

Autor: Robert I. Lechler, Guo Cai Huang, Attilio Pingitore, Richard A. G. Smith, Fang Xiao, Anthony Dorling, Liang Ma, Min Zhao, Giovanna Lombardi, Peter M. Jones, Shanta J. Persaud

Publikováno v: British Journal of Pharmacology. 173:575-587

Background and Purpose A major obstacle to islet cell transplantation is the early loss of transplanted islets resulting from the instant blood‐mediated inflammation reaction (IBMIR). The activation of complement pathways plays a central role in IB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::454b081901f3db8e2c7b9b736ff010d9
https://doi.org/10.1111/bph.13388

LH-21 and abnormal cannabidiol improve β-cell function in isolated human and mouse islets through GPR55-dependent and -independent signalling

Autor: Bo Liu, Guo Cai Huang, Patricio Atanes, Shanta J. Persaud, Inmaculada Ruz-Maldonado, David Baker, Francisco Javier Bermúdez-Silva, Attilio Pingitore, Francisco J. Alonso

Publikováno v: Ruz-Maldonado, I, Pingitore, A, Liu, B, Atanes, P, Huang, G C, Baker, D, Alonso, F J, Bermúdez-Silva, F J & Persaud, S J 2018, ' LH-21 and abnormal cannabidiol improve β-cell function in isolated human and mouse islets through GPR55-dependent and-independent signalling. ', Diabetes, Obesity and Metabolism, vol. 20, no. 4, pp. 930-942 . https://doi.org/10.1111/dom.13180

AimsTo examine the effects of Abn‐CBD (GPR55 agonist) and LH‐21 (CB1 antagonist) on human and mouse islet function, and to determine signalling via GPR55 using islets from GPR55−/− mice.Materials and methodsIslets isolated from human organ do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e252b7ff10a7d1d75350e57a8edaf60
https://hdl.handle.net/10668/11877