Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Attila Reményi"'
Autor:
Dániel Bálint, Ádám Levente Póti, Anita Alexa, Péter Sok, Krisztián Albert, Lili Torda, Dóra Földesi-Nagy, Dániel Csókás, Gábor Turczel, Tímea Imre, Eszter Szarka, Ferenc Fekete, Isabel Bento, Márton Bojtár, Roberta Palkó, Pál Szabó, Katalin Monostory, Imre Pápai, Tibor Soós, Attila Reményi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract There has been a surge of interest in covalent inhibitors for protein kinases in recent years. Despite success in oncology, the off-target reactivity of these molecules is still hampering the use of covalent warhead-based strategies. Herein,
Externí odkaz:
https://doaj.org/article/a3e63eb44b28449ba2031704dd9ee83f
Autor:
Ádám Levente Póti, Dániel Bálint, Anita Alexa, Péter Sok, Kristóf Ozsváth, Krisztián Albert, Gábor Turczel, Sarolt Magyari, Orsolya Ember, Kinga Papp, Sándor Balázs Király, Tímea Imre, Krisztina Németh, Tibor Kurtán, Gergő Gógl, Szilárd Varga, Tibor Soós, Attila Reményi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract For mitogen-activated protein kinases (MAPKs) a shallow surface—distinct from the substrate binding pocket—called the D(ocking)-groove governs partner protein binding. Screening of broad range of Michael acceptor compounds identified a d
Externí odkaz:
https://doaj.org/article/4603a495845c41f6a42a040ea8d5d6e0
Autor:
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this en
Externí odkaz:
https://doaj.org/article/f6d3c3032ebe40f894a83f92cc0e664c
Autor:
Ádám L. Póti, Laura Dénes, Kinga Papp, Csaba Bató, Zoltán Bánóczi, Attila Reményi, Anita Alexa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14854 (2023)
Protein kinases are key regulators of cell signaling and have been important therapeutic targets for three decades. ATP-competitive drugs directly inhibit the activity of kinases but these enzymes work as part of complex protein networks in which pro
Externí odkaz:
https://doaj.org/article/672976cf51e44555afeebf87dd9b5626
Autor:
Anita Alexa, Péter Sok, Fridolin Gross, Krisztián Albert, Evan Kobori, Ádám L. Póti, Gergő Gógl, Isabel Bento, Ersheng Kuang, Susan S. Taylor, Fanxiu Zhu, Andrea Ciliberto, Attila Reményi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The herpesvirus protein ORF45 can bind the two host kinases ERK and RSK but how this affects cell signalling is unclear. Here, the authors show that ORF45 hijacks the ERK-RSK complex by binding to the two kinases with optimized linear motifs and inte
Externí odkaz:
https://doaj.org/article/b1961af753104939b45873b5e2d5dcfc
Autor:
Klára Kirsch, András Zeke, Orsolya Tőke, Péter Sok, Ashish Sethi, Anna Sebő, Ganesan Senthil Kumar, Péter Egri, Ádám L. Póti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Reményi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphor
Externí odkaz:
https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a6
Autor:
Anita Alexa, Orsolya Ember, Ildikó Szabó, Yousef Mo’ath, Ádám L. Póti, Attila Reményi, Zoltán Bánóczi
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Mitogen-activated protein kinases (MAPK) are important regulatory units in cells and they take part in the regulation of many cellular functions such as cell division, differentiation or apoptosis. All MAPKs have a shallow docking groove that interac
Externí odkaz:
https://doaj.org/article/10a444f3e4e44098bd54465bfa952cd0
Autor:
Judit Mohás-Cseh, Gergő Attila Molnár, Marianna Pap, Boglárka Laczy, Tibor Vas, Melinda Kertész, Krisztina Németh, Csaba Hetényi, Orsolya Csikós, Gábor K. Tóth, Attila Reményi, István Wittmann
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 975 (2022)
A link between oxidative stress and insulin resistance has been suggested. Hydroxyl free radicals are known to be able to convert phenylalanine (Phe) into the non-physiological tyrosine isoforms ortho- and meta-tyrosine (o-Tyr, m-Tyr). The aim of our
Externí odkaz:
https://doaj.org/article/79c1ce459192463f8ca0fc4d3ed11ba0
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3320 (2022)
A FBXW7 is an F-box E3 ubiquitin-ligase affecting cell growth by controlling protein degradation. Mechanistically, its effect on its substrates depends on the phosphorylation of degron motifs, but the abundance of these phosphodegrons has not been sy
Externí odkaz:
https://doaj.org/article/bbe7bc4d52e744c5b695d4c9886a60d7
Autor:
Balázs Merő, Kitti Koprivanacz, Anna Cserkaszky, László Radnai, Virag Vas, Gyöngyi Kudlik, Gergő Gógl, Péter Sok, Ádám L. Póti, Bálint Szeder, László Nyitray, Attila Reményi, Miklós Geiszt, László Buday
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8103 (2021)
The scaffold protein Tks4 is a member of the p47phox-related organizer superfamily. It plays a key role in cell motility by being essential for the formation of podosomes and invadopodia. In addition, Tks4 is involved in the epidermal growth factor (
Externí odkaz:
https://doaj.org/article/41d864547c5b4fbfa8afe4b0a14ae6b3