Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Attila Paczal"'
Autor:
Szilárd Tóth, Márton F. Szlávik, Réka Mandel, Fanni Fekecs, Gábor Tusnády, Flóra Vajda, Nóra Varga, Ágota Apáti, Attila Bényei, Attila Paczal, András Kotschy, Gergely Szakács
Publikováno v:
ACS Omega, Vol 9, Iss 29, Pp 32226-32234 (2024)
Externí odkaz:
https://doaj.org/article/79a1802ae16c4eafaec39a09939a8c03
Publikováno v:
Molecules, Vol 27, Iss 18, p 5805 (2022)
The formation of polysubstituted cyclopropane derivatives in the gold(I)-catalyzed reaction of olefins and propargylic esters is a potentially useful transformation to generate diversity, therefore any method in which its stereoselectivity could be c
Externí odkaz:
https://doaj.org/article/dee9873b41614158a5447ccd81f2a9e5
Publikováno v:
International journal of molecular sciences. 23(7)
VCD analysis of 16 diastereomeric pairs of NHC precursors containing two isolated chirality centers and different substitution patterns identified VCD transitions characteristic of the chirality center in the imidazolium ring or in the side chain, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ad02f88a430d67dc8a8c708bd6d4f62
https://pubmed.ncbi.nlm.nih.gov/35408831
https://pubmed.ncbi.nlm.nih.gov/35408831
Autor:
Tamás Gáti, András Kotschy, Attila Paczal, Daniel Simko, Zoltán Novák, Attila Bényei, Ádám Sinai, Fruzsina Szabó
Publikováno v:
European Journal of Organic Chemistry. 2020:1122-1128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9db89b0548c91dcb6ee7f84068ca0e6
https://doi.org/10.1002/ejoc.201901834
https://doi.org/10.1002/ejoc.201901834
Autor:
Attila Paczal, Thomas Edmonds, Nicolas Foloppe, Andrew Massey, András Kotschy, Mike Burbridge, Francisco Cruzalegui, Pawel Dokurno, Didier Demarles, Roderick E. Hubbard, Csaba Wéber, Sipos Melinda, Balázs Bálint, Vilibald Kun, K Benwell, James Murray, Walmsley David, Alain Bruno
Publikováno v:
Journal of medicinal chemistry. 64(10)
The kinase DYRK1A is an attractive target for drug discovery programs due to its implication in multiple diseases. Through a fragment screen, we identified a simple biaryl compound that is bound to the DYRK1A ATP site with very high efficiency, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a128ac92882fb9193bbec98b205ee8c0
https://pubmed.ncbi.nlm.nih.gov/33975430
https://pubmed.ncbi.nlm.nih.gov/33975430
Autor:
Ana-Leticia Maragno, Attila Paczal, András Kotschy, Didier Demarles, James Edward Paul Davidson, Szlávik Zoltán, Allan E. Surgenor, Gaëtane Le Toumelin-Braizat, James Murray, Proszenyák Ágnes, Frédéric Colland, Gabor Radics, Szabolcs Sipos, Olivier Geneste, Balázs Bálint, Csékei Márton, Zoltán B. Szabó, Pawel Dokurno, Audrey Claperon, Anne-Marie Girard, Chen I-Jen, Alain Bruno, Gaëlle Lysiak-Auvity, Roderick E. Hubbard, Maïa Chanrion, Zoe Daniels
Publikováno v:
Journal of medicinal chemistry. 63(22)
Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4627a227ab78ca732e02dade24b1f98
https://pubmed.ncbi.nlm.nih.gov/33146521
https://pubmed.ncbi.nlm.nih.gov/33146521
Autor:
Didier Demarles, James Edward Paul Davidson, Levente Ondi, Allan E. Surgenor, Frédéric Colland, Attila Paczal, Marion Zarka, Alan P. Robertson, Zoltán B. Szabó, András Kotschy, Julia Smith, Perron-Sierra Françoise, Gabor Radics, Audrey Claperon, Ben Davis, Pawel Dokurno, Szlávik Zoltán, Csékei Márton, Gaetane LeToumelin-Braizat, Roderick E. Hubbard, Chen I-Jen, C. Pedder, Olivier Geneste, James Murray, Nicolas Cauquil
Publikováno v:
Journal of medicinal chemistry. 62(15)
Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation when observed in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy, has emerged as an attracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41342aba1a0624428d0d485578fc3d6
https://pubmed.ncbi.nlm.nih.gov/31339316
https://pubmed.ncbi.nlm.nih.gov/31339316
Autor:
James A. H. Murray, Fabien Melchiore, Natalia Matassova, C. Pedder, Frédéric Colland, Catherine Chang, Levente Ondi, Laura C. A. Galbraith, Pawel Dokurno, Andrew W. Roberts, Chris D. Riffkin, Nolwen Guigal-Stephan, Proszenyák Ágnes, John A. Hickman, Andreas Strasser, Aurélie Studeny, Gaëlle Lysiak-Auvity, András Kotschy, Gemma L. Kelly, Fabienne Gravé, Ghislaine Guasconi, Brandon J. Aubrey, Attila Paczal, Julia Smith, Szlávik Zoltán, Gabor Radics, Brian Lockhart, David C.S. Huang, Maïa Chanrion, Gaëtane Le Toumelin-Braizat, Jia-Nan Gong, Nicolas Cauquil, Szabolcs Sipos, Alan P. Robertson, Giovanna Pomilio, James Edward Paul Davidson, Zoltán B. Szabó, Ana Leticia Maragno, Chris Graham, Marco J Herold, Gábor Blasko, Margs S. Brennan, Anne-Marie Girard, Allan E. Surgenor, Andrew H. Wei, Csékei Márton, Olivier Geneste, Chen I-Jen, Alain Bruno, David J. Segal, Guillaume Lessene, Balázs Bálint, Donia M Moujalled
Publikováno v:
Nature. 538:477-482
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e7ae913cad44eb1a7aa5057ee9d4b1
https://doi.org/10.1038/nature19830
https://doi.org/10.1038/nature19830
Autor:
András Kotschy, Isabelle Theret, Attila Paczal, Frédéric De Ceuninck, Zoltán B. Szabó, Catherine Bernard, Alain Ktorza, Balázs Bálint, Csaba Wéber, Perron-Sierra Françoise, Levente Ondi
Publikováno v:
Journal of Medicinal Chemistry. 59:687-706
7-Azaindole has been identified as a novel bidentate anchor point for allosteric glucokinase activators. A systematic investigation around three principal parts of the new small molecule glucokinase activators led to a robust SAR in agreement with st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b2a87148aee12dcf7786d6b8e541f3
https://doi.org/10.1021/acs.jmedchem.5b01594
https://doi.org/10.1021/acs.jmedchem.5b01594
Autor:
András Kotschy, Fruzsina Szabó, Dániel Csaba Simkó, Tamás Gáti, Ádám Sinai, Attila Paczal, Attila Bényei, Zoltán Novák
Publikováno v:
European Journal of Organic Chemistry. 2020:5634-5634
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781ae2bc422557b5ecae4cdb8c0939f1
https://doi.org/10.1002/ejoc.202000761
https://doi.org/10.1002/ejoc.202000761