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pro vyhledávání: '"Attila Egyed"'
PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells
Autor:
Susanne Prokop, Péter Ábrányi-Balogh, Benjámin Barti, Márton Vámosi, Miklós Zöldi, László Barna, Gabriella M. Urbán, András Dávid Tóth, Barna Dudok, Attila Egyed, Hui Deng, Gian Marco Leggio, László Hunyady, Mario van der Stelt, György M. Keserű, István Katona
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The authors introduce PharmacoSTORM single-molecule imaging that uses fluorescent ligands and immunolabeling for cellular and subcellular nanoscale molecular pharmacology. They demonstrate its capabilities by visualizing cariprazine binding to D3 dop
Externí odkaz:
https://doaj.org/article/7fdcba0c8de84fc9bca36e38db68d9ba
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to their pathophysiological significance and pharmacological relevance. Class A receptors represent the largest group of GPCRs that gives the highest number of valid
Externí odkaz:
https://doaj.org/article/f06e3dc4b87d40a09c20a124a3d64df5
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1182 (2022)
There is an unmet need for novel therapeutic tools relieving chronic pain. Hydrogen sulfide (H2S) is highly involved in pain processes; however, the development of ideal matrices for sulfide donor compounds remains a great pharmaceutical challenge. W
Externí odkaz:
https://doaj.org/article/297e54a607eb4782a62b01424575b9cf
Autor:
György M. Keserű, Balázs Volk, Bence Szilágyi, Attila Egyed, István Mándity, Tamás Nagy, Katalin Kátai-Fadgyas
Publikováno v:
Synthesis. 55:959-966
A safe and metal-free process using ethyl glycinate hydrochloride as the starting material has been developed for the preparation of ethyl 5-acetyl-1H-pyrazole-3-carboxylate, a key intermediate for the synthesis of potential blockbuster drug substanc
Autor:
María Isabel Loza, Rob Leurs, Chris de Graaf, András Visegrády, Attila Egyed, György M. Keserű, José Brea, Ádám Andor Kelemen, Stephanie A. Thee, Zhiyong Wang, Márton Vass
Publikováno v:
Bioorganic Chemistry, 111:104832, 1-11. Academic Press Inc.
Egyed, A, Kelemen, Á A, Vass, M, Visegrády, A, Thee, S A, Wang, Z, de Graaf, C, Brea, J, Loza, M I, Leurs, R & Keserű, G M 2021, ' Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule ', Bioorganic Chemistry, vol. 111, 104832, pp. 1-11 . https://doi.org/10.1016/j.bioorg.2021.104832
Egyed, A, Kelemen, Á A, Vass, M, Visegrády, A, Thee, S A, Wang, Z, de Graaf, C, Brea, J, Loza, M I, Leurs, R & Keserű, G M 2021, ' Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule ', Bioorganic Chemistry, vol. 111, 104832, pp. 1-11 . https://doi.org/10.1016/j.bioorg.2021.104832
In addition to the orthosteric binding pocket (OBP) of GPCRs, recent structural studies have revealed that there are several allosteric sites available for pharmacological intervention. The secondary binding pocket (SBP) of aminergic GPCRs is located
Autor:
Attila Egyed
Publikováno v:
Archiv für Religionsgeschichte. :85-121
The present paper provides a plausible interpretation of how a variety of literary elements and religious practices can augment our current understanding of ancient Orphism, although all of the sources seem to reflect a common religious function. The
Autor:
Dóra Judit Kiss, Attila Egyed, István Greiner, Ferenc Horti, György M. Keserű, Katalin Domány-Kovács, Dalma Kurkó, Gáspár Pándy-Szekeres, Bence Koványi
Publikováno v:
Chemical Communications. 56:14167-14170
Receptor function is traditionally controlled from the orthosteric binding site of G-protein coupled receptors. Here, we show that the functional activity and signalling of human dopamine D2 and D3 receptor ligands can be fine-tuned from the extracel
PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells
Autor:
István Katona, Gian Marco Leggio, Attila Egyed, Benjámin Barti, Barna Dudok, László Barna, Hui Deng, Márton Vámosi, Mario van der Stelt, Miklós Zöldi, András Tóth, Susanne Prokop, Gabriella M. Urbán, László Hunyady, György M. Keserű, Péter Ábrányi-Balogh
Publikováno v:
Nature Communications, 12
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Immunolabeling and autoradiography have traditionally been applied as the methods-of-choice to visualize and collect molecular information about physiological and pathological processes. Here, we introduce PharmacoSTORM super-resolution imaging that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a0dc77dcf2cc8ec8c428dcd9fd3297
http://hdl.handle.net/1887/3248679
http://hdl.handle.net/1887/3248679
Autor:
László Petri, György M. Keserű, Anasztázia Hetényi, Tímea Imre, Attila Egyed, Dávid Bajusz, Péter Ábrányi-Balogh, Tamás A. Martinek
Publikováno v:
European journal of medicinal chemistry. 207
Targeted covalent inhibitors represent a viable strategy to block protein kinases involved in different disease pathologies. Although a number of computational protocols have been published for identifying druggable cysteines, experimental approaches
Autor:
Dávid Bajusz, Andrea Scarpino, Anasztázia Hetényi, László Buday, Balázs Merő, Moira Rachman, György M. Keserű, Xavier Barril, Attila Egyed
Publikováno v:
RSC Medicinal Chemistry
A virtual screening workflow for fragment-sized kinase inhibitors is presented, along with a newly identified and validated hinge binder fragment.
One of the key motifs of type I kinase inhibitors is their interactions with the hinge region of A
One of the key motifs of type I kinase inhibitors is their interactions with the hinge region of A