Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice

Autor: Kitti Szőke, Beáta Bódi, Zoltán Hendrik, Attila Czompa, Alexandra Gyöngyösi, Donald David Haines, Zoltán Papp, Árpád Tósaki, István Lekli

Publikováno v: Pharmacology Research & Perspectives, Vol 11, Iss 3, Pp n/a-n/a (2023)

Abstract Previous investigations have demonstrated that treatment of animals with rapamycin increases levels of autophagy, which is a process by which cells degrade intracellular detritus, thus suppressing the emergence of senescent cells, whose pro�

Externí odkaz: https://doaj.org/article/00e790af39c6412c9a663d092bf0f181

Dataset on structure, stability and myocardial effects of a new hybrid aspirin containing nitrogen monoxide-releasing molsidomine moiety

Autor: Kitti Szőke, Attila Czompa, István Lekli, Péter Szabados-Fürjesi, Mihály Herczeg, Magdolna Csávás, Anikó Borbás, Pál Herczegh, Árpád Tósaki

Publikováno v: Data in Brief, Vol 25, Iss , Pp - (2019)

Herein 1H and 13C NMR spectra of ERJ-500, a new hybrid aspirin derivative, covalently conjugated to nitrogen monoxide donor linsidomine are presented as well as NMR spectra of its synthetic intermediate compounds. HPLC-MS measurements data are also i

Externí odkaz: https://doaj.org/article/d7045d51e2844dee8fba7f43fddc44cb

Aged (Black) versus Raw Garlic against Ischemia/Reperfusion-Induced Cardiac Complications

Autor: Attila Czompa, Kitti Szoke, Jozsef Prokisch, Alexandra Gyongyosi, Istvan Bak, Gyorgy Balla, Arpad Tosaki, Istvan Lekli

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 4, p 1017 (2018)

Recent evidence from studies suggests that aged black garlic also has an effect on health. The major aim of the present study is to compare the effect of raw and aged black garlic on postischemic cardiac recovery. Male Sprague Dawley rats were random

Externí odkaz: https://doaj.org/article/d0d57d16e7a7497493ac139b04a686d9

The Cardioprotective Effect of Metformin in Doxorubicin-Induced Cardiotoxicity: The Role of Autophagy

Autor: Tosaki, Rita Zilinyi, Attila Czompa, Andras Czegledi, Andrea Gajtko, Dora Pituk, Istvan Lekli, Arpad

Publikováno v: Molecules; Volume 23; Issue 5; Pages: 1184

The molecular mechanisms underlying doxorubicin-induced cardiotoxicity are still being investigated, but are known to involve oxidative stress, mitochondrial dysfunction, and the dysregulation of autophagy. The objective of the current study was to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::75e9fba6f7c7d7c6982dbe69db4281f5

The Effects of Long-Term, Low- and High-Dose Beta-Carotene Treatment in Zucker Diabetic Fatty Rats: The Role of HO-1

Autor: Istvan Bak, Arpad Tosaki, József Balla, György Balla, Evelin Csepanyi, Istvan Lekli, Peter Szabados-Furjesi, Attila Czompa

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 4, p 1132 (2018)
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1132
International Journal of Molecular Sciences

Nowadays, there is a growing interest in compounds derived from plants as potential raw materials for drug development. One of the most studied compounds is beta-carotene (BC). Several clinical studies can be found investigating the cardiovascular ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2be403ad69638be6b7b07365f26fcc
http://www.mdpi.com/1422-0067/19/4/1132