Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines.

Autor: Joonas P Kosonen, Atte S A Eskelinen, Gustavo A Orozco, Petteri Nieminen, Donald D Anderson, Alan J Grodzinsky, Rami K Korhonen, Petri Tanska

Publikováno v: PLoS Computational Biology, Vol 19, Iss 1, p e1010337 (2023)

Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology o

Externí odkaz: https://doaj.org/article/3a8c6b41b00c4d9f943981ac4df3f824

Multiscale In Silico Modeling of Cartilage Injuries

Autor: Rami K. Korhonen, Atte S. A. Eskelinen, Gustavo A. Orozco, Amir Esrafilian, Cristina Florea, Petri Tanska

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9783031255878

Injurious loading of the joint can be accompanied by articular cartilage damage and trigger inflammation. However, it is not well-known which mechanism controls further cartilage degradation, ultimately leading to post-traumatic osteoarthritis. For p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b45ac7e66c583c775b248147a7fa95e9
https://doi.org/10.1007/978-3-031-25588-5_3

Shear strain and inflammation-induced fixed charge density loss in the knee joint cartilage following ACL injury and reconstruction: A computational study

Autor: Xiaojuan Li, Joonas P. Kosonen, Thomas M. Link, Gustavo A. Orozco, Alan J. Grodzinsky, M. Tanaka, Atte S. A. Eskelinen, Mingrui Yang, Benjamin Ma, Petri Tanska, Rami K. Korhonen

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, vol 40, iss 7
Journal of orthopaedic research
J Orthop Res

Excessive tissue deformation near cartilage lesions and acute inflammation within the knee joint after anterior cruciate ligament (ACL) rupture and reconstruction surgery accelerate the loss of fixed charge density (FCD) and subsequent cartilage tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebeba88fc05e1b4f74b2f3daa231165
https://escholarship.org/uc/item/8sp846q2

Maximum shear strain-based algorithm can predict proteoglycan loss in damaged articular cartilage

Autor: Mika E. Mononen, Mikko S. Venäläinen, Rami K. Korhonen, Petri Tanska, Atte S. A. Eskelinen

Publikováno v: Biomechanics and Modeling in Mechanobiology

Post-traumatic osteoarthritis (PTOA) is a common disease, where the mechanical integrity of articular cartilage is compromised. PTOA can be a result of chondral defects formed due to injurious loading. One of the first changes around defects is prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f46e836f072dfa81e6526b4347b6c9

Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus.

Autor: Eskelinen, Atte S. A.¹ (AUTHOR) attees@uef.fi, Tanska, Petri¹ (AUTHOR), Florea, Cristina^1,2 (AUTHOR), Orozco, Gustavo A.¹ (AUTHOR), Julkunen, Petro^1,3 (AUTHOR), Grodzinsky, Alan J.² (AUTHOR), Korhonen, Rami K.¹ (AUTHOR)

Publikováno v: PLoS Computational Biology. 6/25/2020, Vol. 16 Issue 6, p1-25. 25p. 5 Diagrams, 1 Chart, 2 Graphs.