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A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's ataxia

Autor: Campos, Oscar A, Attar, Narsis, Cheng, Chen, Vogelauer, Maria, Mallipeddi, Nathan V, Schmollinger, Stefan, Matulionis, Nedas, Christofk, Heather R, Merchant, Sabeeha S, Kurdistani, Siavash K

Publikováno v: Science advances, vol 7, iss 51

Disruptions to iron-sulfur (Fe-S) clusters, essential cofactors for a broad range of proteins, cause widespread cellular defects resulting in human disease. A source of damage to Fe-S clusters is cuprous (Cu1+) ions. Since histone H3 enzymatically pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::f57985dbe41ae065cc29d0a8fd0490ea
https://escholarship.org/uc/item/3vt8c06d

P-228 Use of cilta-cel CAR T cells following previous use of a BCMA-directed CAR T-cell product in heavily treated patients with relapsed/refractory multiple myeloma: a single institution case series

Autor: Attar, Narsis, Cirstea, Diana, Branagan, Andrew, Yee, Andrew, Frigault, Matthew, Raje, Noopur

Publikováno v: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 2:S161-S161

Histones at the Nexus of Eukaryotic Evolution and Biology

Autor: Attar, Narsis

Publikováno v: Attar, Narsis. (2017). Histones at the Nexus of Eukaryotic Evolution and Biology. UCLA: Molecular Biology 0573. Retrieved from: http://www.escholarship.org/uc/item/3v87f2ts

Histones have long been known for their functions in packaging the eukaryotic genome and in regulating DNA-based processes. These functions are dependent on physical and chemical properties of histones constructing the nucleosome, the basic structura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5bd38d4cd871faf8d1a57559d5fd9f4e
http://www.escholarship.org/uc/item/3v87f2ts

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

Autor: Recio Juan A, Glaspy John A, Ng Charles, Sazegar Hooman, Matsunaga Doug, Guo Deliang, Attar Narsis, von Euw Erika, Niehr Franziska, Lo Roger S, Mischel Paul S, Comin-Anduix Begonya, Ribas Antoni

Publikováno v: Journal of Translational Medicine, Vol 9, Iss 1, p 76 (2011)

Abstract Background A molecular linkage between the MAPK and the LKB1-AMPK energy sensor pathways suggests that combined MAPK oncogene inhibition and metabolic modulation of AMPK would be more effective than either manipulation alone in melanoma cell

Externí odkaz: https://doaj.org/article/07f1a3c842bf4d638c59891157f0e629