Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Atta U. Shahbaz"'
Autor:
Syamal K. Bhattacharya, Atta U. Shahbaz, Karl T. Weber, Patti L. Johnson, Ivan C. Gerling, Wenyuan Zhao, Robert A. Ahokas, Tieqiang Zhao, Yao Sun
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 300:H636-H644
Acute hyperadrenergic stressor states are accompanied by cation dyshomeostasis, together with the release of cardiac troponins predictive of necrosis. The signal-transducer-effector pathway accounting for this pathophysiological scenario remains uncl
Autor:
Patti L. Johnson, Atta U. Shahbaz, Syamal K. Bhattacharya, Robert A. Ahokas, Karl T. Weber, Ivan C. Gerling, Tieqiang Zhao, Yao Sun, Wenyuan Zhao, German Kamalov
Publikováno v:
Journal of Cardiovascular Pharmacology. 57:37-43
Chronic aldosterone/salt treatment (ALDOST) is accompanied by an adverse structural remodeling of myocardium that includes multiple foci of microscopic scarring representing morphologic footprints of cardiomyocyte necrosis. Our previous studies sugge
Autor:
Ivan C. Gerling, Robert A. Ahokas, Jesse E. McGee, Karl T. Weber, Atta U. Shahbaz, Yao Sun, Syamal K. Bhattacharya
Publikováno v:
Journal of Hypertension. 28:S25-S32
Fibrosis is a fundamental component of the adverse structural remodelling of myocardium found in hypertensive heart disease (HHD). A replacement fibrosis appears at sites of previous cardiomyocyte necrosis to preserve the structural integrity of the
Autor:
Yao Sun, Atta U. Shahbaz, Ivan C. Gerling, Syamal K. Bhattacharya, Wenyuan Zhao, Patti L. Johnson, Robert A. Ahokas, Tieqiang Zhao, German Kamalov, Karl T. Weber
Publikováno v:
Journal of Cardiovascular Pharmacology. 55:248-254
Intracellular [Ca2+]i overloading in cardiomyocytes is a fundamental pathogenic event associated with chronic aldosterone/salt treatment (ALDOST) and accounts for an induction of oxidative stress that leads to necrotic cell death and consequent myoca
Autor:
Syamal K. Bhattacharya, Karl T. Weber, Atta U. Shahbaz, Wenyuan Zhao, Ivan C. Gerling, Yao Sun, German Kamalov, Robert A. Ahokas
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 298:H385-H394
Intracellular Ca2+overloading, coupled to induction of oxidative stress, is present at 4-wk aldosterone/salt treatment (ALDOST). This prooxidant reaction in cardiac myocytes and mitochondria accounts for necrotic cell death and subsequent myocardial
Autor:
Karl T. Weber, Richard C. Davis, Stephen P. Laguardia, J. Lacey Smith, Haris Zafarullah, Ragheed Alturkmani, Basil M. Paulus, David L. Battin, M. Omer Afzal, Atta U. Shahbaz
Publikováno v:
The American Journal of the Medical Sciences. 336:383-388
Serum cobalamin (vitamin B12), bound to transcobalamin II, is taken up by the endothelium of the hepatic vasculature via a receptor-mediated membrane transport process. We hypothesized hepatic congestion is associated with elevated serum B12 without
Autor:
Robert A. Ahokas, Karl T. Weber, Ivan C. Gerling, Yaser Cheema, M. Usman Khan, Syamal K. Bhattacharya, Yao Sun, Atta U. Shahbaz
The survival of cardiomyocytes must be ensured as the myocardium adjusts to a myriad of competing physiological and pathophysiological demands. A significant loss of these contractile cells, together with their replacement by stiff fibrillar collagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a424374afbddd0a3c6c471aec185260
https://europepmc.org/articles/PMC3386379/
https://europepmc.org/articles/PMC3386379/
Publikováno v:
European heart journal. 32(15)
An ongoing loss of cardiomyocytes to apoptotic and necrotic cell death pathways contributes to the progressive nature of heart failure. The pathophysiological origins of necrotic cell loss relate to the neurohormonal activation that accompanies acute
Autor:
German Kamalov, Karl T. Weber, Atta U. Shahbaz, Syamal K. Bhattacharya, Malay S. Gandhi, Robert A. Ahokas, Ivan C. Gerling, Yao Sun
Fibrosis is a fundamental component of the adverse structural remodeling of myocardium present in the failing heart. Replacement fibrosis appears at sites of previous cardiomyocyte necrosis to preserve the structural integrity of the myocardium, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273a3871e31c928e3ccb661600defd5e
https://europepmc.org/articles/PMC2920342/
https://europepmc.org/articles/PMC2920342/
Autor:
Syamal K. Bhattacharya, Yao Sun, Atta U. Shahbaz, Karl T. Weber, Yaser Cheema, Robert A. Ahokas, Ivan C. Gerling
Publikováno v:
Molecular Defects in Cardiovascular Disease ISBN: 9781441971296
A progressive loss of cardiomyocytes contributes to the heart’s failure as a muscular pump. This includes the necrotic death of these cells, which are replaced by fibrous tissue (vis-a-vis apoptotic cell death). In the explanted failing heart, scat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::963a17e5c1f09819e4e280bebc7a0f83
https://doi.org/10.1007/978-1-4419-7130-2_1
https://doi.org/10.1007/978-1-4419-7130-2_1