Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Atsutoshi Ota"'
Publikováno v:
Pharmaceutical Research. 19:108-111
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f14aa3a4924747adb5677bbf984803
https://doi.org/10.1023/a:1013671819604
https://doi.org/10.1023/a:1013671819604
Autor:
Hideo Takashina, Atsutoshi Ota, Kouichi Kawazu, Hiromistu Shiono, Hidetoshi Tanioka, Toshimi Ikuse, Yoichi Kawashima
Publikováno v:
Current Eye Research. 17:125-131
To determine whether cultured rabbit corneal epithelial cells (RCEC), grown on permeable supports, provide a suitable in vivo model for characterizing transcellular drug permeation and metabolism.Primary rabbit corneal epithelial cells grown in DMEM-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973fcd1a0ebba44b61f9b5135cb79676
https://doi.org/10.1076/ceyr.17.2.125.5598
https://doi.org/10.1076/ceyr.17.2.125.5598
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:281-288
The pharmacokinetics of levofloxacin (LVFX) was investigated after a single or repeated topical application of 0.5% 14C-LVFX ophthalmic solution to pigmented rats. In the case of repeated application, the ophthalmic solution was instilled 3 times a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8fb8d2a9f6ba37e034246c83828fdfb
https://doi.org/10.2133/dmpk.12.281
https://doi.org/10.2133/dmpk.12.281
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:542-546
Structure-Ca2+ antagonistic activity relationships of semotiadil (1) congeners having a benzothiazine cyclic system were studied quantitatively by the Hansch-Fujita method. A quadratic dependency of the activity on ClogP, a lipophilic descriptor, of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c432fa400816efae17ff84b3664697
https://doi.org/10.1248/cpb.44.542
https://doi.org/10.1248/cpb.44.542
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:876-881
A series of N-(mercaptoalkyl)thiazolidine-2-thiones and their derivatives were synthesized and evaluated for hepatoprotective activities against Propionibacterium acnes-lipopolysaccharide (P. acnes-LPS)-induced liver injury in mice and in vitro lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa75ca6976c45f4526a91bda3d05fa77
https://doi.org/10.1248/cpb.41.876
https://doi.org/10.1248/cpb.41.876
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:1681-1685
The stereochemistry of a novel Ca2+ antagonist, semotiadil, 1, was investigated using X-ray crystallography and CD. The X-ray structure was analyzed using its diastereomeric salt with (S)-(+)-mandelic acid (2); 1 (mandelate). The R absolute configura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcb16dd8942c2e8c13756fba0037146b
https://doi.org/10.1248/cpb.41.1681
https://doi.org/10.1248/cpb.41.1681
Publikováno v:
ChemInform. 26
A series of N-(mercaptoalkyl)thiazolidine-2-thiones and their derivatives were synthesized and evaluated for hepatoprotective activities against Propionibacterium acnes-lipopolysaccharide (P. acnes-LPS)-induced liver injury in mice and in vitro lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd3bbdfe8b34f2304aa1c7bd14d9e24
https://doi.org/10.1002/chin.199506168
https://doi.org/10.1002/chin.199506168
Publikováno v:
Journal of Chromatography A. 626:187-196
A new derivatization procedure has been developed for converting enantiomeric thiol compounds into their diastereomers for resolution by reversed-phase liquid chromatography. The thiol compounds were derivatized with 2,3,4,6-tetra-O-acetyl-β- d -glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eaedff8b6fb767cba17fd6dedd7add0
https://doi.org/10.1016/0021-9673(92)85409-m
https://doi.org/10.1016/0021-9673(92)85409-m
Publikováno v:
Journal of Chromatography A. 593:37-40
Enantiomers of 3,4-dihydro-2-{;5-methoxy-2-[3-(N-methyl-N-{;2-[(3,4-methylenedioxy)phenoxy]ethyl};amino)propoxy]phneyl};-4-methyl-3-oxo-2H-1,4- benzothiazine hydorgen fumarate (I), a novel and potent Ca 2+ antagonist, and its synthetic pecursors, phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::024a325e992ade42806b8df946cc2f21
https://doi.org/10.1016/0021-9673(92)80263-t
https://doi.org/10.1016/0021-9673(92)80263-t
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:833-836
Chiroptical properties of (R)-(+)- and (S)-(-)-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-2H-1, 4-benzothiazin-3(4H)-one ((R)- and (S)-2), and (S)-(-)-4-methyl-2-phenyl-2H-1, 4-benzothiazin-3(4H)-one ((S)-3), related compounds with a novel Ca2+ antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b0843d17f50d96d2b817b8b503867a
https://doi.org/10.1248/cpb.40.833
https://doi.org/10.1248/cpb.40.833