Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Atsushi Takatori"'
Autor:
Akiko Tsujimoto, Niina Matsuo, Xiaoyi Lai, Takahiro Inoue, Hiroyuki Yoda, Jason Lin, Yoshinao Shinozaki, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Hiroki Nagase
Publikováno v:
Cancer Medicine, Vol 12, Iss 5, Pp 5821-5832 (2023)
Abstract Background Activating mutations of the KRAS occurs in >90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, direct pharmacological targeting of the activated KRAS protein has been challenging. We previously reported that KR12, a DN
Externí odkaz:
https://doaj.org/article/703738c350c64285acb203fb3004436f
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/c726a50aa68a424490e72067c601ac31
Autor:
Atsushi Takatori, MD. Shamim Hossain, Atsushi Ogura, Jesmin Akter, Yohko Nakamura, Akira Nakagawara
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Receptor tyrosine kinases (RTKs) receive different modulation before transmitting proliferative signals. We previously identified neuronal leucine-rich repeat 1 (NLRR1) as a positive regulator of EGF and IGF-1 signals in high-risk neuroblastoma cells
Externí odkaz:
https://doaj.org/article/4782a393cfdc44a092b5032aa209ae42
Autor:
Yoko Ota, Hiroyuki Yoda, Takahiro Inoue, Takayoshi Watanabe, Yoshinao Shinozaki, Atsushi Takatori, Hiroki Nagase
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257718 (2021)
Anaplastic lymphoma kinase (ALK) aberration is related to high-risk neuroblastomas and is an important therapeutic target. As acquired resistance to ALK tyrosine kinase inhibitors is inevitable, novel anti-ALK drug development is necessary in order t
Externí odkaz:
https://doaj.org/article/1d529d07ac064cc28b1c168739c8a509
Autor:
Jason Lin, Sakthisri Krishnamurthy, Hiroyuki Yoda, Yoshinao Shinozaki, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Paul Horton, Hiroki Nagase
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215247 (2019)
In the search for new pharmaceutical leads, especially with DNA-binding molecules or genome editing methods, the issue of side and off-target effects have always been thorny in nature. A particular case is the investigation into the off-target effect
Externí odkaz:
https://doaj.org/article/8cffcabb95e24c59a33ec16c71c420ff
Autor:
Jason Lin, Kiriko Hiraoka, Takayoshi Watanabe, Tony Kuo, Yoshinao Shinozaki, Atsushi Takatori, Nobuko Koshikawa, Anandhakumar Chandran, Joe Otsuki, Hiroshi Sugiyama, Paul Horton, Hiroki Nagase
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165581 (2016)
Pyrrole-imidazole polyamides are versatile DNA minor groove binders and attractive therapeutic options against oncological targets, especially upon functionalization with an alkylating agent such as seco-CBI. These molecules also provide an alternati
Externí odkaz:
https://doaj.org/article/6ddeaa21b84b42e0834e8733972bd6ff
Autor:
Yusuke Suenaga, S M Rafiqul Islam, Jennifer Alagu, Yoshiki Kaneko, Mamoru Kato, Yukichi Tanaka, Hidetada Kawana, Shamim Hossain, Daisuke Matsumoto, Mami Yamamoto, Wataru Shoji, Makiko Itami, Tatsuhiro Shibata, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Atsushi Takatori, Akira Nakagawara
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1003996 (2014)
The rearrangement of pre-existing genes has long been thought of as the major mode of new gene generation. Recently, de novo gene birth from non-genic DNA was found to be an alternative mechanism to generate novel protein-coding genes. However, its f
Externí odkaz:
https://doaj.org/article/270703329fc643b2a63b9ef7ab54a3f1
Autor:
Akiko Tsujimoto, Niina Matsuo, Xiaoyi Lai, Takahiro Inoue, Hiroyuki Yoda, Jason Lin, Yoshinao Shinozaki, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Hiroki Nagase
Publikováno v:
Cancer Medicine. 12:5821-5832
Activating mutations of the KRAS occurs in90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, direct pharmacological targeting of the activated KRAS protein has been challenging. We previously reported that KR12, a DNA-alkylating pyrrole-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4890db49b2e6f239a95b685c42ceb57
https://doi.org/10.1002/cam4.5359
https://doi.org/10.1002/cam4.5359
Autor:
Takafumi Kondo, Shohei Honda, Hiromu Suzuki, Yoichi M. Ito, Issei Kawakita, Kazuyoshi Okumura, Momoko Ara, Masashi Minato, Norihiko Kitagawa, Yukichi Tanaka, Mio Tanaka, Masato Shinkai, Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Atsushi Takatori, Eiso Hiyama, Akinobu Taketomi
Publikováno v:
European Journal of Cancer. 172:311-322
Hepatoblastoma (HB) is the most common paediatric liver tumour, and epigenetic aberrations may be important in HB development. Recently, the Children's Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) developed risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b715d4577199424e3d5e777cfd4f1a0
https://doi.org/10.1016/j.ejca.2022.06.013
https://doi.org/10.1016/j.ejca.2022.06.013
Autor:
Akira Nakagawara, Yusuke Suenaga, Miki Ohira, Atsuko Nakazawa, Toshinori Ozaki, Md. Shamim Hossain, Atsushi Takatori, Jesmin Akter
Purpose: Our previous study showed that expression of NLRR3 is significantly high in favorable neuroblastomas (NBL), whereas that of NLRR1 is significantly high in unfavorable NBLs. However, the molecular mechanism of transcriptional regulation of NL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47faea45525290b7c3732aea9cfccad7
https://doi.org/10.1158/1078-0432.c.6520131
https://doi.org/10.1158/1078-0432.c.6520131
