Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Atsushi Suenaga"'
Publikováno v:
Biophysical Journal. 121:4770-4776
RNA aptamers are oligonucleotides with high binding affinity and specificity for target molecules and are expected to be a new generation of therapeutic molecules and targeted delivery materials. The tertiary structure of RNA molecules and RNA-protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8811022c7fd0215cf30d642878cf5afb
https://doi.org/10.1016/j.bpj.2022.09.023
https://doi.org/10.1016/j.bpj.2022.09.023
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42846 (2012)
Virtual compound screening using molecular docking is widely used in the discovery of new lead compounds for drug design. However, the docking scores are not sufficiently precise to represent the protein-ligand binding affinity. Here, we developed an
Externí odkaz:
https://doaj.org/article/d49edc9d90db4d8580d38b0911ae5e7f
Autor:
Noriaki Okimoto, Noriyuki Futatsugi, Hideyoshi Fuji, Atsushi Suenaga, Gentaro Morimoto, Ryoko Yanai, Yousuke Ohno, Tetsu Narumi, Makoto Taiji
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 10, p e1000528 (2009)
Virtual compound screening using molecular docking is widely used in the discovery of new lead compounds for drug design. However, this method is not completely reliable and therefore unsatisfactory. In this study, we used massive molecular dynamics
Externí odkaz:
https://doaj.org/article/ef230170b12d4529906bf1f6807f8913
Autor:
Morihiro Kawase, Ayumi Shiro, Hirokazu Ikeda, Atsushi Suenaga, Choji Saji, Hidenori Toyokawa, Takahisa Shobu, Ryo Yasuda, Koji Ohara
Publikováno v:
Proceedings of the Second International Symposium on Radiation Detectors and Their Uses (ISRD2018).
エネルギー分散X線回折実験用に高エネルギーX線に対応可能なCdTe素子を用いたピクセル型検出器を開発した。
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a66de5e799aeb0b2092934b2e6d1f0
https://doi.org/10.7566/jpscp.24.011015
https://doi.org/10.7566/jpscp.24.011015
Publikováno v:
Journal of Computer Chemistry, Japan. 13:278-291
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c5be235bf8f67cf49e59d06fa421e8e
https://doi.org/10.2477/jccj.2014-0040
https://doi.org/10.2477/jccj.2014-0040
Autor:
Osamu Nakagomi, Toyoko Nakagomi, Atsushi Suenaga, Miyu Fuzawa, Takayuki Miura, Takeshi Yoshimura, Satoshi Okabe, Daisuke Sano
Publikováno v:
Journal of Virology. 87:9441-9451
Histo-blood group antigens (HBGAs) have been suggested to be receptors or coreceptors for human noroviruses (HuNoVs) expressed on the intestinal epithelium. We isolated an enteric bacterium strain (SENG-6), closely related to Enterobacter cloacae , b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09266651d51100db28bba81fad94ea1e
https://doi.org/10.1128/jvi.01060-13
https://doi.org/10.1128/jvi.01060-13
Autor:
Kazuhiko Fukui, Hidewo Kusano, Tomohisa Hatta, Tohru Natsume, Riko Tanaka, Kazutaka Araki, Atsushi Suenaga
Publikováno v:
Biochemical and biophysical research communications. 481(3-4)
Molecular organization of the eukaryote chaperonin known as CCT/TRiC complex was recently clarified. Eight distinct subunits are uniquely organized, providing a favorable folding cavity for specific client proteins such as tubulin and actin. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfceac8e57a38a2265b25b4e2b5161f
https://pubmed.ncbi.nlm.nih.gov/27806916
https://pubmed.ncbi.nlm.nih.gov/27806916
Publikováno v:
Scientific Reports
In order to investigate the contribution of individual amino acids to protein and peptide solubility, we carried out 100 ns molecular dynamics (MD) simulations of 106 Å3 cubic boxes containing ~3 × 104 water molecules and 27 tetra-peptides regularl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e54dab817d42cea5b71576a5eee6fad
In computational drug design, ranking a series of compound analogs in a manner that is consistent with experimental affinities remains a challenge. In this study, we evaluated the prediction of protein-ligand binding affinities using steered molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244c49700b3a27da67732ac127bfa189
Publikováno v:
The Journal of Physical Chemistry Letters. 3:3476-3479
The process of binding of small ligands to dihydrofolate reductase protein has been investigated using all-atom molecular dynamics simulations. The existence of a mechanism that facilitates the search of the binding site by the ligand is demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf7352fdcb6e527b418e3ff08f560fb
https://doi.org/10.1021/jz301635h
https://doi.org/10.1021/jz301635h