Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Atsushi Sawamoto"'
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 779 (2023)
“Frailty” caused by a decline in physiological reserve capacity, chronic inflammation, and oxidative stress in the elderly has recently become a major social issue. The present study examined the effects of the peel of Citrus kawachiensis (CK), w
Externí odkaz:
https://doaj.org/article/7f988887c5474823bc7ff8b34e7efadc
Autor:
Yoshiko Furukawa, Yu-suke Washimi, Ryu-ichi Hara, Mizuki Yamaoka, Satoshi Okuyama, Atsushi Sawamoto, Mitsunari Nakajima
Publikováno v:
Molecules, Vol 25, Iss 5, p 1117 (2020)
(1) Background: Our published data have indicated that (1) auraptene (AUR), a citrus ingredient, has neuroprotective effects on the mouse brain, owing to its ability to suppress inflammation, such as causing a reduction in hyperactivation of microgli
Externí odkaz:
https://doaj.org/article/4780c2cae5c84fc0993d3c4a715ab66b
Autor:
Yoshiko Furukawa, Ryu-ichi Hara, Makiko Nakaya, Satoshi Okuyama, Atsushi Sawamoto, Mitsunari Nakajima
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 253 (2019)
We previously demonstrated that auraptene (AUR), a natural coumarin derived from citrus plants, exerts anti-inflammatory effects in the brain, resulting in neuroprotection in some mouse models of brain disorders. The present study showed that treatme
Externí odkaz:
https://doaj.org/article/b2a7094f752e4c579db88a38a9c78dbe
Autor:
Satoshi Okuyama, Mayu Morita, Atsushi Sawamoto, Tsukasa Terugo, Mitsunari Nakajima, Yoshiko Furukawa
Publikováno v:
Pharmaceuticals, Vol 8, Iss 2, Pp 176-185 (2015)
Edaravone, a clinical drug used to treat strokes, protects against neuronal cell death and memory loss in the ischemic brains of animal models through its antioxidant activity. In the present study, we subcutaneously administrated edaravone to mice (
Externí odkaz:
https://doaj.org/article/1d651c4fdf2644d08378a9b3c00706f3
Autor:
Yoshiko Furukawa, Atsushi Sawamoto, Mizuki Yamaoka, Makiko Nakaya, Yuhzo Hieda, Tominari Choshi, Noriyuki Hatae, Satoshi Okuyama, Mitsunari Nakajima, Satoshi Hibino
Publikováno v:
Molecules, Vol 24, Iss 7, p 1366 (2019)
Many studies have demonstrated that oxidative stress plays an important role in several ailments including neurodegenerative diseases and cerebral ischemic injury. Previously we synthesized some carbazole compounds that have anti-oxidant ability in v
Externí odkaz:
https://doaj.org/article/2fcfb2ab8ff148ca9a779afe5b2799ca
Autor:
Satoshi Okuyama, Tatsumi Nakashima, Kumi Nakamura, Wakana Shinoka, Maho Kotani, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa
Publikováno v:
Antioxidants, Vol 7, Iss 8, p 109 (2018)
Auraptene, a citrus-related compound, exerts anti-inflammatory effects in peripheral tissues, and we demonstrated these effects in the brains of a lipopolysaccharide-injected systemic inflammation animal model and a brain ischemic mouse model. Naring
Externí odkaz:
https://doaj.org/article/48c8f777c6134fdf9f55f2745f0a0aa1
Autor:
Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Morio Yoshimura, Takashi Yamada, Hidehiko Yokogoshi, Mitsunari Nakajima, Yoshiko Furukawa
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 10, p 2133 (2017)
We previously reported that the subcutaneous administration of 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), a citrus polymethoxyflavone, attenuated depressive-like behavior and increased the expression of brain-derived neurotrophic factor (BDNF) in
Externí odkaz:
https://doaj.org/article/6ef53e1be7e14f6da643bfb091217c1c
Autor:
Satoshi Okuyama, Kohei Miyazaki, Rie Yamada, Yoshiaki Amakura, Morio Yoshimura, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 3, p 489 (2017)
Accumulating data have indicated that citrus polymethoxyflavones (PMFs) have the ability to affect brain function. In the present study, we showed that 3,5,6,7,8,3′,4′-heptamethoxy- flavone (HMF) given intraperitoneally to mice was immediately de
Externí odkaz:
https://doaj.org/article/bd4ac067022644d4b4f301ee94139dc2
Autor:
Satoshi Okuyama, Tomoki Semba, Nobuki Toyoda, Francesco Epifano, Salvatore Genovese, Serena Fiorito, Vito Alessandro Taddeo, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 10, p 1716 (2016)
In patients with Parkinson’s disease (PD), hyperactivated inflammation in the brain, particularly microglial hyperactivation in the substantia nigra (SN), is reported to be one of the triggers for the delayed loss of dopaminergic neurons and sequen
Externí odkaz:
https://doaj.org/article/fa14d6726d5e4b01b0ec82e486b79149
Autor:
Atsushi Sawamoto, Satoshi Okuyama, Kana Yamamoto, Yoshiaki Amakura, Morio Yoshimura, Mitsunari Nakajima, Yoshiko Furukawa
Publikováno v:
Molecules, Vol 21, Iss 4, p 541 (2016)
We previously reported that the citrus flavonoid 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF) increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a transient global ischemia mouse model. Since the BDNF hypothes
Externí odkaz:
https://doaj.org/article/a1819a4df3c048b6833a32b989211da9