Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Atsushi Sanbuissho"'
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 9, Pp 3397-3412 (2010)
A systems-level understanding of molecular perturbations is crucial for evaluating chemical-induced toxicity risks appropriately, and for this purpose comprehensive gene expression analysis or toxicogenomics investigation is highly advantageous. The
Externí odkaz:
https://doaj.org/article/95ce03239c7e469ab0a6f388948b7e5c
Autor:
Masao Odaka, Kiyoshi Takasuna, Yasuyuki Abe, Yumiko Asahi, Atsushi Sanbuissho, Fumimasa Nomura, Kenji Matsuura, Akihiro Hattori, Kenji Yasuda, Tomoyuki Kaneko, Tomoyo Hamada
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
We examined a simultaneous combined spatiotemporal field potential duration (FPD) and cell-to-cell conduction time (CT) in lined-up shaped human embryonic stem cell-derived cardiomyocytes (hESC-CMs) using an on-chip multielectrode array (MEA) system
Autor:
Takanori Maejima, Isao Igarashi, Shingo Arakawa, Munehiro Teranishi, Atsushi Sanbuissho, Kiyonori Kai
Publikováno v:
Experimental and Toxicologic Pathology. 66(2-3):103-110
Gap junctional intercellular communication (GJIC), by which glutathione (GSH) and inorganic ions are transmitted to neighboring cells, is recognized as being largely involved in toxic processes of chemicals. We examined acetaminophen (APAP)-induced h
Autor:
Atsushi Sanbuissho, Kazuhiko Mori, Tsutomu Kimura, Tadashi Furukawa, Tetsuo Aida, Ryota Kawai, Shiho Ito, Teruo Kawada, Hiroyuki Hattori
Publikováno v:
Journal of Immunotoxicology. 10:40-48
To develop a rat T-cell-dependent antibody response (TDAR) model evaluating both primary and secondary antibody responses, keyhole limpet hemocyanin (KLH) was used to immunize rats twice during a 14-day course of study, a pattern closely linked to th
Publikováno v:
Journal of Toxicologic Pathology
The effect of hypertension on the occurrence of micro-hemorrhage in the pancreatic islet, known to be observed in Sprague-Dawley (SD) rats spontaneously, and endothelial markers were investigated in male Dahl-Iwai salt-sensitive (DIS, derived from SD
Autor:
Philip W. Iversen, Joseph A. Jakubowski, James J. Starling, Lorrene A. Buckley, Mary Pat Knadler, Atsushi Sanbuissho
Publikováno v:
International Journal of Toxicology. 31:317-325
Prasugrel, a thienopyridine ADP receptor antagonist, is an orally administered prodrug requiring in vivo metabolism to form the active metabolite that irreversibly inhibits platelet activation and aggregation mediated by the P2Y12[sub 12] receptor. A
Autor:
Makoto Shirai, Tomoe Tanimoto, Takanori Maejima, Kazuyoshi Kumagai, Toshihiko Makino, Atsushi Sanbuissho, Munehiro Teranishi, Kiyonori Kai
Publikováno v:
Journal of Toxicologic Pathology
Multiple whitish nodules in the thoracic cavity at the site of the thymus were observed in a 101-week-old male ICR mouse. In a histopathological examination, the neoplastic cells were predominantly fusiform in shape and proliferated in sarcomatoid gr
Autor:
Kazuhiro Shimomura, Yoshihisa Uenoyama, Hitoshi Ohnishi, Toshiki Matsuoka, Hiroko Tsukamura, Junko Suzuki, Kei-ichiro Maeda, Toshihiko Makino, Atsushi Sanbuissho, Ken-ichi Noritake
Publikováno v:
Reproductive Toxicology. 31:440-446
Mechanism mediating the testicular toxicity induced by CS-003, a triple neurokinin receptor antagonist, was investigated in male dogs. Daily CS-003 administrations showed testicular toxicity, such as a decrease in the sperm number, motility and prost
Autor:
Sunao Manabe, Naoki Kiyosawa, Shusuke Yamauchi, Noriyo Niino, Kyoko Watanabe, Atsushi Sanbuissho, Yosuke Ando, Kazumi Ito, Takashi Yamoto
Publikováno v:
Archives of Toxicology. 85:1045-1056
Hepatic transcriptome and proteome responses against glutathione depletion were investigated by Affymetrix GeneChip Microarray and 2-dimensional gel electrophoresis (2D-DIGE), followed by MALDI-TOF-MS analysis and utilizing a glutathione-depleted rat
Publikováno v:
Chemico-Biological Interactions. 188:404-411
Glutathione plays an important role as not only a scavenger of reactive oxygen species but also in the conjugation or detoxification of electrophilic reactive metabolites, which has been thought to be one of the causes for idiosyncratic drug toxicity