Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Atsushi Nonami"'
Autor:
Ellen Weisberg, Qingsong Liu, Xin Zhang, Erik Nelson, Martin Sattler, Feiyang Liu, Maria Nicolais, Jianming Zhang, Constantine Mitsiades, Robert W Smith, Richard Stone, Ilene Galinsky, Atsushi Nonami, James D Griffin, Nathanael Gray
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56473 (2013)
OBJECTIVES:Tyrosine kinase inhibitor (TKI)-treated acute myeloid leukemia (AML) patients commonly show rapid and significant peripheral blood blast cell reduction, however a marginal decrease in bone marrow blasts. This suggests a protective environm
Externí odkaz:
https://doaj.org/article/60d1836fda314928b444dce1a800b64e
Autor:
Koji Nagafuji, Atsushi Nonami, Takashi Kumano, Yoshikane Kikushige, Goichi Yoshimoto, Katsuto Takenaka, Kazuya Shimoda, Shouichi Ohga, Masaki Yasukawa, Hisanori Horiuchi, Eiichi Ishii, Mine Harada
Publikováno v:
Haematologica, Vol 92, Iss 7 (2007)
Perforin gene (PRF1) mutations cause the primary form of hemophagocytic lymphohistiocytosis (HLH). We report a genetic defect of PRF1 in a 62-year-old Japanese man with recurrent episodes of HLH. Sequencing of PRF1 from both peripheral blood mononucl
Externí odkaz:
https://doaj.org/article/e641ca072bae43a5a2fc8e79ac37ba93
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77652698c8f5e96ead4e624b606e372c
https://doi.org/10.1158/1535-7163.22506793
https://doi.org/10.1158/1535-7163.22506793
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
Supplementary Table III: AML patient samples tested with HDM2 inhibitor, CGM097: IC50 values for CGM097.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d9f78b11fd339b51f82e9097596b5f
https://doi.org/10.1158/1535-7163.22506781.v1
https://doi.org/10.1158/1535-7163.22506781.v1
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
The tumor suppressor p53 is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating Bcl-2 family proteins. In cells expressing wild-type (WT) p53, the HDM2 protein binds to p53 and block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a202bb70fbbf98f1078a1bda4271a89
https://doi.org/10.1158/1535-7163.c.6538492.v1
https://doi.org/10.1158/1535-7163.c.6538492.v1
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
Supplementary Figures 1-7 Supplementary Figure 1. Amplification and sequencing primers used for genotyping of p53 in AML patient samples. Supplementary Figure 2. Apoptosis data corresponding to representative bar graphs shown in Figure 1C. Supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c85fda8083880149c6582ea722cbd30
https://doi.org/10.1158/1535-7163.22506790
https://doi.org/10.1158/1535-7163.22506790
Autor:
James D. Griffin, Nathanael S. Gray, Qingsong Liu, Kwok-Kin Wong, Constantine Mitsiades, Martin Sattler, Jianming Zhang, HaeYeon Cho, Feiyang Liu, Yongfei Chen, Erik Nelson, Zhao Chen, Atsushi Nonami, Ellen Weisberg
Purpose: Activating mutations in the RAS oncogene occur frequently in human leukemias. Direct targeting of RAS has proven to be challenging, although targeting of downstream RAS mediators, such as MEK, is currently being tested clinically. Given the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406800bb299c19e44374d952405a48ac
https://doi.org/10.1158/1078-0432.c.6524589.v1
https://doi.org/10.1158/1078-0432.c.6524589.v1
Autor:
James D. Griffin, Nathanael S. Gray, Qingsong Liu, Kwok-Kin Wong, Constantine Mitsiades, Martin Sattler, Jianming Zhang, HaeYeon Cho, Feiyang Liu, Yongfei Chen, Erik Nelson, Zhao Chen, Atsushi Nonami, Ellen Weisberg
Figure Legends for data shown in supplementary data section
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1307723d7b970570e2b3c0974ed444d2
https://doi.org/10.1158/1078-0432.22460781.v1
https://doi.org/10.1158/1078-0432.22460781.v1
Autor:
James D. Griffin, Nathanael S. Gray, Qingsong Liu, Kwok-Kin Wong, Constantine Mitsiades, Martin Sattler, Jianming Zhang, HaeYeon Cho, Feiyang Liu, Yongfei Chen, Erik Nelson, Zhao Chen, Atsushi Nonami, Ellen Weisberg
Supplementary Figure 1. Schematic of LINCS library chemical screen. Supplementary Figure 2. Selectivity of LINCS library kinase inhibitors toward mutant NRAS-expressing cells. Supplementary Figure 3. Proliferation studies showing positive combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f0c29f748fc88f7f1972b17966928d
https://doi.org/10.1158/1078-0432.22460778.v1
https://doi.org/10.1158/1078-0432.22460778.v1
Autor:
Masataka Ikeda, Tomomi Ide, Shouji Matsushima, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Tomonori Tadokoro, Masashi Sada, Ko Abe, Midori Sato, Akiko Hanada, Shinobu Arai, Kisho Ohtani, Atsushi Nonami, Shinichi Mizuno, Sachio Morimoto, Shinichiro Motohashi, Koichi Akashi, Masaru Taniguchi, Hiroyuki Tsutsui
Publikováno v:
Circulation. Heart failure.
Background: Dilated cardiomyopathy (DCM) is a life-threatening disease, resulting in refractory heart failure. An immune disorder underlies the pathophysiology associated with heart failure progression. Invariant natural killer T (iNKT) cell activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ff6288d21886932562c6ffb82ff281
https://pubmed.ncbi.nlm.nih.gov/36268712
https://pubmed.ncbi.nlm.nih.gov/36268712