Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Atsushi Nii"'
Autor:
Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111929- (2023)
Summary: The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In the current study, we investigate whether events occurring at the invasion front are of particular impo
Externí odkaz:
https://doaj.org/article/36523fb8ccbc455a9c49d7317c9ee01e
Autor:
Akio Uemura, Jiro Hirose, Toshiko Ozawa, Yuji Nagao, Toshihisa Miura, Mitsuko Isaji, Atsushi Nii, Katsuaki Kato, Kazuya Yamashiro
Publikováno v:
Biological and Pharmaceutical Bulletin. 21:651-656
Urinary trypsin inhibitor (UTI) is a physiological protease inhibitor and inter-alpha-trypsin inhibitor (ITI) is regarded as a precursor of UTI. The purpose of this study is to determine the mechanism of the UTI release from ITI. To examine this, ITI
Publikováno v:
Japanese Journal of Thrombosis and Hemostasis. 6:203-207
Autor:
Keisuke Sugihara, Hideaki Morishita, Toshinori Kanamori, Hideaki Umeyama, Jiro Hirose, Mitsuko Isaji, Tomokazu Matsusue, Toshihisa Miura, Yoshifumi Horisawa, Toru Yamakawa, Atsushi Nii
Publikováno v:
The Journal of Biochemistry. 115:1107-1112
The second domain (R-020) of human urinary trypsin inhibitor (UTI) exerts similar inhibitory activities on trypsin, alpha-chymotrypsin, leukocyte elastase, and plasmin to those of UTI itself, and additionally inhibits coagulation factor Xa (FXa) and
Publikováno v:
Biological and Pharmaceutical Bulletin. 21:167-169
Human inter-alpha-trypsin-inhibitor (ITI) is a serine proteinase inhibitor with a molecular weight of 220 kDa which consists of 3 different polypeptides. The constitutive components are 2 heavy chains (H1 and H2 chains) and 1 light chain (L chain), a
Autor:
Takaaki Negishi, Fumio Umeda, Toshihiko Hashimoto, Hiroko Koushima, Atsushi Okamoto, Atsushi Nii, Toshinori Kanamori, Seiichi Mizushima, Hironori Sato, Hajime Nawata
Publikováno v:
Journal of biochemistry. 120(5)
Prostacyclin-stimulating factor (PSF) is a protein which acts on vascular endothelial cells and stimulates the production of prostacyclin. Recently, we were able to purify PSF from the conditioned medium of cultured human diploid fibroblasts and clon
Autor:
Rie Sameshima-Aruga, Yasukazu Nagase, Tomokazu Matsusue, Masahiro Nobuhara, Toru Yamakawa, Atsushi Nii, Sadatoshi Koyama, Jiro Hirose, Reiko Horisawa-Nakano, Masaaki Naotsuka, Mitsuko Isaji, Toshihisa Miura, Hideaki Morishita, Ryo Tanaka, Takeshi Kusuyama, Toshinori Kanamori
Publikováno v:
Thrombosis research. 73(3-4)
Urinary trypsin inhibitor is a glycoprotein with a structure in which two Kunitz-type inhibitory domains are linked in a row. We isolated two genes encoding the 70 amino acid sequence from the 78th amino acid (Thr) to the C-terminal and the 68 amino
Autor:
Kuniaki Sato, Takaaki Masuda, Qingjiang Hu, Taro Tobo, Sarah Gillaspie, Atsushi Niida, Mackenzie Thornton, Yousuke Kuroda, Hidetoshi Eguchi, Takashi Nakagawa, Katsura Asano, Koshi Mimori
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 387-402 (2019)
Background: Translational reprogramming through controlled initiation from non-AUG start codons is considered a crucial driving force in tumorigenesis and tumor progression. However, its clinical impact and underlying mechanism are not fully understo
Externí odkaz:
https://doaj.org/article/2de3a6e8311344458ad956e83ed0a466
Autor:
Shotaro Sakimura, Satoshi Nagayama, Mitsuko Fukunaga, Qingjiang Hu, Akihiro Kitagawa, Yuta Kobayashi, Takanori Hasegawa, Miwa Noda, Yuta Kouyama, Dai Shimizu, Tomoko Saito, Atsushi Niida, Yusuke Tsuruda, Hajime Otsu, Yoshihiro Matsumoto, Hiroki Uchida, Takaaki Masuda, Keishi Sugimachi, Shin Sasaki, Kazutaka Yamada, Kazuki Takahashi, Hideki Innan, Yutaka Suzuki, Hiromi Nakamura, Yasushi Totoki, Shinichi Mizuno, Masanobu Ohshima, Tatsuhiro Shibata, Koshi Mimori
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009113 (2021)
A Darwinian evolutionary shift occurs early in the neutral evolution of advanced colorectal carcinoma (CRC), and copy number aberrations (CNA) are essential in the transition from adenoma to carcinoma. In light of this primary evolution, we investiga
Externí odkaz:
https://doaj.org/article/368965ee3f5c406883ce91f3142e4dd0
Autor:
Tomoiki Aiba, Chieko Hattori, Jun Sugisaka, Hisashi Shimizu, Hirotaka Ono, Yutaka Domeki, Ryohei Saito, Sachiko Kawana, Yosuke Kawashima, Keisuke Terayama, Yukihiro Toi, Atsushi Nakamura, Shinsuke Yamanda, Yuichiro Kimura, Yutaka Suzuki, Atsushi Niida, Shunichi Sugawara
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260500 (2021)
Although anti-PD-1/PD-L1 monotherapy has achieved clinical success in non-small cell lung cancer (NSCLC), definitive predictive biomarkers remain to be elucidated. In this study, we performed whole-transcriptome sequencing of pretreatment tumor tissu
Externí odkaz:
https://doaj.org/article/ff8d011cd2ee41c8b003de2f9220edcd