Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Atsushi Naganawa"'
Publikováno v:
European Journal of Organic Chemistry. 2020:3491-3498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f25573a4814b09092e6492e2c2d0a26
https://doi.org/10.1002/ejoc.202000464
https://doi.org/10.1002/ejoc.202000464
Autor:
Yoshiyuki Aratani, Hidekazu Matsuya, Koji Yoshida, Masato Higashino, Atsushi Naganawa, Hiroyuki Takeda, Akihiro Kinoshita, Keisuke Hanada, Kazuyuki Ohmoto, Akito Kakuuchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:200-214
A highly potent and well-balanced dual agonist for the EP2 and EP3 receptors is described. Optimization of the lead compound was accomplished in consideration of the relative agonist activity against each EP subtype receptor and the pharmacokinetic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56e5a038bf3b1ac9687e5fd070824092
https://doi.org/10.1016/j.bmc.2017.11.035
https://doi.org/10.1016/j.bmc.2017.11.035
Autor:
Masanori Iwaki, Hidenori Miyata, Atsushi Naganawa, Akira Imagawa, Takuya Nishio, Jun Katagi, Yasuyuki Okabe, Takeshi Matsushita, Tatsuya Komagata, Akiharu Ishida, Toru Maruyama, Tetsuya Sekiguchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 49:116424
Somatostatin receptors are members of G-protein coupled receptor superfamily. Receptors can be classified into five subtypes, SSTR1 to 5. The highly potent and orally active SSTR2 agonist 7, which had been identified by our group, was found out to ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4730bdf3d329b17feaea2d19b0e0ab
https://doi.org/10.1016/j.bmc.2021.116424
https://doi.org/10.1016/j.bmc.2021.116424
Autor:
Kazuhiro Otsuki, Hiroshi Yamamoto, Haruto Kurata, Ai Hashimoto, Koji Shinozaki, Takeshi Matsushita, Takuya Seko, Yoshiyuki Yamaura, Tetsuya Sekiguchi, Kensuke Kusumi, Akito Kakuuchi, Atsushi Naganawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1209-1213
The structure of the S1P2 antagonist 1 has been modified with the aim of improving its oral bioavailability. The chemical modification of the alkyl chain and carboxylic acid moieties of 1 led to significant improvements in the oral exposure of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25a2df178b653cedb5d031676d280d5
https://doi.org/10.1016/j.bmcl.2016.01.031
https://doi.org/10.1016/j.bmcl.2016.01.031
Autor:
Hideyuki Ueda, Ai Hashimoto, Tetsuya Sekiguchi, Kazuhiro Otsuki, Takuya Seko, Kensuke Kusumi, Haruto Kurata, Akito Kakuuchi, Yoshiyuki Yamaura, Atsushi Naganawa, Koji Shinozaki, Takeshi Matsushita
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4387-4392
Our initial lead compound 2 was modified to improve its metabolic stability. The resulting compound 5 showed excellent metabolic stability in rat and human liver microsomes. We subsequently designed and synthesized a hybrid compound of 5 and the 1,3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee7eda0e3ed88ff58ed6cf0b673fbb6
https://doi.org/10.1016/j.bmcl.2015.09.022
https://doi.org/10.1016/j.bmcl.2015.09.022
Autor:
Akito Kakuuchi, Haruto Kurata, Kazuhiro Otsuki, Tetsuya Sekiguchi, Atsushi Naganawa, Koji Shinozaki, Takeshi Matsushita, Kensuke Kusumi, Takuya Seko, Kanaji Toshiya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1479-1482
The structure–activity relationships of a novel series of sphingosine-1-phosphate receptor antagonists have been examined in detail. The initial hit compound 1 was modified through synthesis to improve its S1P2 activity. The synthesis of a series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe897b0e5487ff42688c85ffea02bdb8
https://doi.org/10.1016/j.bmcl.2015.02.029
https://doi.org/10.1016/j.bmcl.2015.02.029
Autor:
Akihiro, Kinoshita, Masato, Higashino, Koji, Yoshida, Yoshiyuki, Aratani, Akito, Kakuuchi, Keisuke, Hanada, Hiroyuki, Takeda, Atsushi, Naganawa, Hidekazu, Matsuya, Kazuyuki, Ohmoto
Publikováno v:
Bioorganicmedicinal chemistry. 26(1)
A highly potent and well-balanced dual agonist for the EP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cecf82fc6035858f7d7798ca4b5c57c2
https://pubmed.ncbi.nlm.nih.gov/29203142
https://pubmed.ncbi.nlm.nih.gov/29203142
Autor:
Yoko Matsunaga, Seiji Ogawa, Hisao Nakai, Yutaka Okada, Atsushi Shimabukuro, Kohki Tsukamoto, Fumio Nambu, Atsushi Kinoshita, Rie Oumi, Yoshihiko Odagaki, Ryoji Matsumoto, Atsushi Naganawa, Jun Katagi, Maki Iwahashi, Koji Yano, Masaaki Toda, Toshihiko Nishiyama, Kousuke Tani
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:6935-6948
To identify an orally available drug candidate, a series of 3-benzoylaminophenylacetic acids were synthesized and evaluated as prostaglandin D2 (PGD2) receptor antagonists. Some of the compounds tested were found to exhibit excellent inhibitory activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee81d7e76196c761d039147212cacff
https://doi.org/10.1016/j.bmc.2011.08.065
https://doi.org/10.1016/j.bmc.2011.08.065
Publikováno v:
Journal of the American Chemical Society. 132:15790-15799
We have designed and synthesized oligosubstituted bullvalenes 1 and 2 as adaptive molecules that can change their shapes in order to bind tightly to a suitable guest. By incorporation of a photolabile o-nitroveratryloxycarbonate (NVOC) group into bul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c3b93db7785ec3bcbc94252057e477
https://doi.org/10.1021/ja107314p
https://doi.org/10.1021/ja107314p
Autor:
Toshiaki Matsui, Masaki Ima, Hiroshi Yamamoto, Masaaki Toda, Hiroki Okada, Koji Yoshida, Shingo Yamamoto, Hiroshi Tsuruta, Atsushi Naganawa, Takayuki Maruyama, Kigen Kondo, Hisao Nakai
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:7774-7789
A series of 4-[(2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}phenoxy)methyl]benzoic acids and 4-({2-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)benzoic acids were synthesized and evaluated for their EP receptor affinities and EP1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce58ba348aff0f7695b5f2975facafe
https://doi.org/10.1016/j.bmc.2006.08.001
https://doi.org/10.1016/j.bmc.2006.08.001