Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Atsushi Miyanohara"'
Autor:
Shanshan Wang, Joseph S. Leem, Sonia Podvin, Vivian Hook, Natalia Kleschevnikov, Paul Savchenko, Mehul Dhanani, Kimberly Zhou, Isabella C. Kelly, Tong Zhang, Atsushi Miyanohara, Phuong Nguyen, Alexander Kleschevnikov, Steve L. Wagner, John Q. Trojanowski, David M. Roth, Hemal H. Patel, Piyush M. Patel, Brian P. Head
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 434-450 (2021)
Alzheimer’s disease (AD) is the most common form of neurodegeneration and cognitive dysfunction in the elderly. Identifying molecular signals that mitigate and reverse neurodegeneration in AD may be exploited therapeutically. Transgenic AD mice (PS
Externí odkaz:
https://doaj.org/article/9a008a9a994349fab892e7d7e193a9c9
Autor:
Dimosthenis Giamouridis, BS, MS, Mei Hua Gao, PhD, N. Chin Lai, PhD, Zhen Tan, PhD, Young Chul Kim, PhD, Tracy Guo, BS, Atsushi Miyanohara, PhD, W. Matthijs Blankesteijn, PhD, Erik Biessen, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)
Summary: UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plas
Externí odkaz:
https://doaj.org/article/7f669bc55c904d3d97cf15fd9a30d1e9
Publikováno v:
PeerJ, Vol 5, p e3905 (2017)
Small interference RNA has been widely used to suppress gene expression. Three different short hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mou
Externí odkaz:
https://doaj.org/article/7c1deccb23d34e69a80903ef822ef8d4
Autor:
Atsushi Miyanohara, Kota Kamizato, Stefan Juhas, Jana Juhasova, Michael Navarro, Silvia Marsala, Nada Lukacova, Marian Hruska-Plochan, Erik Curtis, Brandon Gabel, Joseph Ciacci, Eric T Ahrens, Brian K Kaspar, Don Cleveland, Martin Marsala
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult a
Externí odkaz:
https://doaj.org/article/2656793c9c4b4a1bb3e8f01a16e8dd29
Autor:
Osamu Kakinohana, Michael P Hefferan, Atsushi Miyanohara, Tetsuya Nejime, Silvia Marsala, Stefan Juhas, Jana Juhasova, Jan Motlik, Karolina Kucharova, Jan Strnadel, Oleksandr Platoshyn, Peter Lazar, Jan Galik, Laurent Vinay, Martin Marsala
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30561 (2012)
Loss of GABA-mediated pre-synaptic inhibition after spinal injury plays a key role in the progressive increase in spinal reflexes and the appearance of spasticity. Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effec
Externí odkaz:
https://doaj.org/article/6169f72d417149448f6d6d804c355c24
Autor:
Qinghao Xu, Beverly Chou, Bethany Fitzsimmons, Atsushi Miyanohara, Veronica Shubayev, Camila Santucci, Michael Hefferan, Martin Marsala, Xiao-Ying Hua
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32581 (2012)
We report here in adult rat viral vector mediate-gene knockdown in the primary sensory neurons and the associated cellular and behavior consequences. Self-complementary adeno-associated virus serotype 5 (AAV5) was constructed to express green fluores
Externí odkaz:
https://doaj.org/article/53cbb180e9f24d978ff89f0d522e0b86
Autor:
Brian P Head, Jason N Peart, Mathivadhani Panneerselvam, Takaakira Yokoyama, Matthew L Pearn, Ingrid R Niesman, Jacqueline A Bonds, Jan M Schilling, Atsushi Miyanohara, John Headrick, Sameh S Ali, David M Roth, Piyush M Patel, Hemal H Patel
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15697 (2010)
The aged brain exhibits a loss in gray matter and a decrease in spines and synaptic densities that may represent a sequela for neurodegenerative diseases such as Alzheimer's. Membrane/lipid rafts (MLR), discrete regions of the plasmalemma enriched in
Externí odkaz:
https://doaj.org/article/e9ff5077de67451e9e57a9790d69abee
Autor:
Takahiro Tadokoro, Mariana Bravo-Hernandez, Kirill Agashkov, Yoshiomi Kobayashi, Oleksandr Platoshyn, Michael Navarro, Silvia Marsala, Atsushi Miyanohara, Tetsuya Yoshizumi, Michiko Shigyo, Volodymyr Krotov, Stefan Juhas, Jana Juhasova, Duong Nguyen, Helena Kupcova Skalnikova, Jan Motlik, Hana Studenovska, Vladimir Proks, Rajiv Reddy, Shawn P. Driscoll, Thomas D. Glenn, Taratorn Kemthong, Suchinda Malaivijitnond, Zoltan Tomori, Ivo Vanicky, Manabu Kakinohana, Samuel L. Pfaff, Joseph Ciacci, Pavel Belan, Martin Marsala
Publikováno v:
Molecular Therapy. 30:2722-2745
Second-order spinal cord excitatory neurons play a key role in spinal processing and transmission of pain signals to the brain. Exogenously induced change in developmentally imprinted excitatory neurotransmitter phenotypes of these neurons to inhibit
Autor:
Isabella C. Kelly, Mehul Dhanani, John Q. Trojanowski, Kimberly Zhou, Sonia Podvin, Steve L. Wagner, Atsushi Miyanohara, Shanshan Wang, Piyush M. Patel, Tong Zhang, Vivian Hook, Alexander M. Kleschevnikov, Phuong Nguyen, Joseph Leem, Natalia Kleschevnikov, Brian P. Head, David M. Roth, Hemal H. Patel, Paul Savchenko
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 434-450 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 434-450 (2021)
Alzheimer’s disease (AD) is the most common form of neurodegeneration and cognitive dysfunction in the elderly. Identifying molecular signals that mitigate and reverse neurodegeneration in AD may be exploited therapeutically. Transgenic AD mice (PS
Autor:
Shanshan, Wang, Taiga, Ichinomiya, Paul, Savchenko, Dongsheng, Wang, Atsushi, Sawada, Xiaojing, Li, Tiffany, Duong, Wenxi, Li, Jacqueline A, Bonds, Eun Jung, Kim, Atsushi, Miyanohara, David M, Roth, Hemal H, Patel, Piyush M, Patel, Takahiro, Tadokoro, Martin, Marsala, Brian P, Head
Publikováno v:
Theranostics. 12(12)
Elevating neuroprotective proteins using adeno-associated virus (AAV)-mediated gene delivery shows great promise in combating devastating neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) is one such disease resulting from loss of upper