Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Atsushi Miyajima"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Chronic liver injury induces fibrosis that often proceeds to cirrhosis and hepatocellular carcinoma, indicating that prevention and/or resolution of fibrosis is a promising therapeutic target. Hepatic stellate cells (HSCs) are the major driv
Externí odkaz:
https://doaj.org/article/5dfc9d6cb6644a27a78fe1b6b36ad4c8
Autor:
Nobutaka Takeda, Atsunori Tsuchiya, Masaki Mito, Kazuki Natsui, Yui Natusi, Yohei Koseki, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Hiroyuki Abe, Masayuki Sano, Taketomo Kido, Yusuke Yoshioka, Junichi Kikuta, Tohru Itoh, Ken Nishimura, Masaru Ishii, Takahiro Ochiya, Atsushi Miyajima, Shuji Terai
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-14 (2023)
Abstract Background The progression of liver fibrosis leads to portal hypertension and liver dysfunction. However, no antifibrotic agents have been approved for cirrhosis to date, making them an unmet medical need. Small extracellular vesicles (sEVs)
Externí odkaz:
https://doaj.org/article/33ffc1abeeee43bea1671cd58272c823
Autor:
Yuichi Tsuchiya, Takao Seki, Kenta Kobayashi, Sachiko Komazawa-Sakon, Shigeyuki Shichino, Takashi Nishina, Kyoko Fukuhara, Kenichi Ikejima, Hidenari Nagai, Yoshinori Igarashi, Satoshi Ueha, Akira Oikawa, Shinya Tsurusaki, Soh Yamazaki, Chiharu Nishiyama, Tetuo Mikami, Hideo Yagita, Ko Okumura, Taketomo Kido, Atsushi Miyajima, Kouji Matsushima, Mai Imasaka, Kimi Araki, Toru Imamura, Masaki Ohmuraya, Minoru Tanaka, Hiroyasu Nakano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Liver fibrosis results from chronic liver injury triggered by factors such as viral infection, excess alcohol intake, and lipid accumulation. However, the mechanisms underlying liver fibrosis are not fully understood. Here, we demonstrate th
Externí odkaz:
https://doaj.org/article/634090b816f84d4c88ef880ddf06cc84
Autor:
Yasuhiro Nakano, Sachie Nakao, Minako Sueoka, Daigo Kasahara, Yuri Tanno, Hideaki Sumiyoshi, Tohru Itoh, Atsushi Miyajima, Katsuto Hozumi, Yutaka Inagaki
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Dll4/Notch1 signal promotes the progression of HCC, while Jag1/Notch2 signal antagonistically suppresses it in murine chemical hepatocarcinogenesis. Nakano et al. report that two distinct Notch signals regulate the progression of hepatocellular carci
Externí odkaz:
https://doaj.org/article/b8d8d5deaba64e4cbc50de2a16ed8551
Autor:
Naoki Tanimizu, Norihisa Ichinohe, Yasushi Sasaki, Tohru Itoh, Ryo Sudo, Tomoko Yamaguchi, Takeshi Katsuda, Takafumi Ninomiya, Takashi Tokino, Takahiro Ochiya, Atsushi Miyajima, Toshihiro Mitaka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Combining mouse hepatocyte progenitors and cholangiocytes ex vivo, the authors form an organoid that can drain bile ex vivo and transport metabolites, as in the liver.
Externí odkaz:
https://doaj.org/article/5ae34e70df8044cf9ed9cd6e6564d196
Autor:
Ami Watanabe, Anna Tanaka, Chizuko Koga, Masahito Matsumoto, Yasushi Okazaki, Tatsuya Kin, Atsushi Miyajima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Generation of pancreatic β cells from pluripotent stem cells is a key technology to develop cell therapy for insulin-dependent diabetes and considerable efforts have been made to produce β cells. However, due to multiple and lengthy differ
Externí odkaz:
https://doaj.org/article/0045ce09fa434bfe9dd473e76af13f0e
Autor:
Suguru Takeuchi, Atsunori Tsuchiya, Takahiro Iwasawa, Shunsuke Nojiri, Takayuki Watanabe, Masahiro Ogawa, Tomoaki Yoshida, Katsunori Fujiki, Yuta Koui, Taketomo Kido, Yusuke Yoshioka, Mayu Fujita, Junichi Kikuta, Tohru Itoh, Masaaki Takamura, Katsuhiko Shirahige, Masaru Ishii, Takahiro Ochiya, Atsushi Miyajima, Shuji Terai
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Mesenchymal stromal cells (MSCs) are used for ameliorating liver fibrosis and aiding liver regeneration after cirrhosis; Here, we analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) p
Externí odkaz:
https://doaj.org/article/ade7176a775045be931db93405b53155
Autor:
Eiji Sato, Masakazu Umezawa, Atsushi Miyajima, Noriko Koishi, Arisa Kanaya, Ayumi Yamanaka, Manabu Fujimoto, Yoshiyuki Ishii, Aki Saito, Sae Inoue, Yasunari Mano, Tatsunori Suzuki, Rie Ozeki, Norihisa Ishii, Masayo Komoda
Publikováno v:
Journal of Cutaneous Immunology and Allergy, Vol 4, Iss 1, Pp 4-12 (2021)
Abstract Objectives The combination therapy of phenothrin (PHT) and ivermectin (PI regimen) was effective for pyrethroid‐resistant head lice in Okinawa; however, further investigations have been required to improve the regimen. This study aimed to
Externí odkaz:
https://doaj.org/article/fdb0b11aa14b449891217f4ce30efef1
Autor:
Marie Shinohara, Hyunjin Choi, Masato Ibuki, Shigeharu G. Yabe, Hitoshi Okochi, Atsushi Miyajima, Yasuyuki Sakai
Publikováno v:
Regenerative Therapy, Vol 12, Iss , Pp 14-19 (2019)
A differentiation of human induced pluripotent stem cells (hiPSCs) into definitive endoderm linage is required for a preparation of metabolic organ derived cells. The differentiation consumed high-priced cytokines and small molecules, which have hamp
Externí odkaz:
https://doaj.org/article/35d27136ce874b4d870ceb04ee8de67e
Autor:
Mathieu Danoy, Yannick Tauran, Stephane Poulain, Rachid Jellali, Johanna Bruce, Marjorie Leduc, Morgane Le Gall, Yuta Koui, Hiroshi Arakawa, Francoise Gilard, Bertrand Gakiere, Yukio Kato, Charles Plessy, Taketomo Kido, Atsushi Miyajima, Yasuyuki Sakai, Eric Leclerc
Publikováno v:
APL Bioengineering, Vol 5, Iss 2, Pp 026104-026104-13 (2021)
Interactions between the different liver cell types are critical to the maintenance or induction of their function in vitro. In this work, human-induced Pluripotent Stem Cells (hiPSCs)-derived Liver Sinusoidal Endothelial Cells (LSECs) and Hepatocyte
Externí odkaz:
https://doaj.org/article/e70436d4d10a4e2393e6907ba57b1f84