Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Atsushi Kudo"'
Autor:
Kohei Yagi, Hiroaki Ono, Atsushi Kudo, Yuko Kinowaki, Daisuke Asano, Shuichi Watanabe, Yoshiya Ishikawa, Hiroki Ueda, Keiichi Akahoshi, Shinji Tanaka, Minoru Tanabe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract O6-methylguanine-DNA methyltransferase (MGMT) has been linked with alkylating agent resistance and tumor growth suppression. However, its role remains undetermined in pancreatic neuroendocrine tumors (Pan-NET). The MGMT expression was examin
Externí odkaz:
https://doaj.org/article/717280156c1f40bca51c69037f7492b3
Publikováno v:
Machine Learning with Applications, Vol 12, Iss , Pp 100473- (2023)
As the damage caused by heavy rainfall worsens, there is a growing demand for improved forecasts. One practical approach to address this issue is the linear integration of multiple existing forecasts, which allows for visualizing the contribution of
Externí odkaz:
https://doaj.org/article/3f276bd665454884b59cac11a1c3dfaf
Autor:
Yoshiki Murase, Atsushi Kudo, Keiichi Akahoshi, Aya Maekawa, Yoshiya Ishikawa, Hiroki Ueda, Kosuke Ogawa, Hiroaki Ono, Shinji Tanaka, Minoru Tanabe
Publikováno v:
Annals of Gastroenterological Surgery, Vol 5, Iss 5, Pp 692-700 (2021)
Abstract Background Little research is available regarding the treatments combining surgical resection with systemic chemotherapy for advanced pancreatic neuroendocrine neoplasm patients. We retrospectively elucidated whether sunitinib administration
Externí odkaz:
https://doaj.org/article/c548b1c09528405583b08096eac1aea3
Autor:
Masafumi Akasu, Shu Shimada, Ayano Kabashima, Yoshimitsu Akiyama, Masahiro Shimokawa, Keiichi Akahoshi, Atsushi Kudo, Shoji Yamaoka, Minoru Tanabe, Shinji Tanaka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Comprehensive analysis of clinical samples has recently identified molecular and immunological classification of hepatocellular carcinoma (HCC), and the CTNNB1 (β-catenin)-mutated subtype exhibits distinctive characteristics of immunosuppre
Externí odkaz:
https://doaj.org/article/63c7a6b15ee74a9d819e44b8f20fa851
Autor:
Hiroaki Ono, Tomotaka Kato, Yoshiki Murase, Yutaro Nakamura, Yoshiya Ishikawa, Shuichi Watanabe, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Daisuke Ban, Atsushi Kudo, Yoshimitsu Akiyama, Shinji Tanaka, Hiromichi Ito, Minoru Tanabe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The activity of histone acetyltransferases (HATs) plays a central role in an epigenetic modification in cooperation with HDACs (histone deacetyl transferases). It is likely that malfunction of this enzymatic machinery controlling epigenetic
Externí odkaz:
https://doaj.org/article/ec83439cf09a4bad9247afe1778a20c3
Autor:
Yoshiki Murase, Daisuke Ban, Aya Maekawa, Shuichi Watanabe, Yoshiya Ishikawa, Keiichi Akahoshi, Kosuke Ogawa, Hiroaki Ono, Atsushi Kudo, Toshifumi Kudo, Shinji Tanaka, Minoru Tanabe
Publikováno v:
Surgical Case Reports, Vol 6, Iss 1, Pp 1-8 (2020)
Abstract Background Pancreatic cancer is a disease with a poor prognosis, requiring multidisciplinary treatment combining chemotherapy and surgery for effective management. Distal pancreatectomy with celiac axis resection (DP-CAR) is a surgical inter
Externí odkaz:
https://doaj.org/article/e8978a3ab76d40c6937434b5ce495c7b
Autor:
Hirofumi Watanabe, Yuto Yamazaki, Fumiyoshi Fujishima, Komoto Izumi, Masayuki Imamura, Susumu Hijioka, Kazuhiro Toriyama, Yasushi Yatabe, Atsushi Kudo, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Streptozocin (STZ) is used for treating both pancreatic (PanNET) and gastrointestinal (GI-NET) neuroendocrine tumors but its therapeutic efficacy is relatively low in GI-NETs. Therefore, it has become pivotal to select GI-NET pati
Externí odkaz:
https://doaj.org/article/9515e351a9c3405ea2b346a87c38e0ce
Autor:
Shu Shimada, Kaoru Mogushi, Yoshimitsu Akiyama, Takaki Furuyama, Shuichi Watanabe, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Minoru Tanabe, Jack R. Wands, Shinji Tanaka
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 457-470 (2019)
Background: Hepatocellular carcinoma (HCC) is a heterogeneous disease with various etiological factors, and ranks as the second leading cause of cancer-related mortality worldwide due to multi-focal recurrence. We herein identified three major subtyp
Externí odkaz:
https://doaj.org/article/279bdbc8fe8b4e0f9d663319b13fa2dc
Autor:
Tomotaka Kato, Hiroaki Ono, Mikiya Fujii, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Daisuke Ban, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe
Publikováno v:
PLoS ONE, Vol 16, Iss 6 (2021)
Background RRM1 is functionally associated with DNA replication and DNA damage repair. However, the biological activity of RRM1 in pancreatic cancer remains undetermined. Methods To determine relationships between RRM1 expression and the prognosis of
Externí odkaz:
https://doaj.org/article/45fc51b43693459b8c9f0e7abe4301d0
Autor:
Kikuko Amo-Shiinoki, Katsuya Tanabe, Yoshinobu Hoshii, Hiroto Matsui, Risa Harano, Tatsuya Fukuda, Takato Takeuchi, Ryotaro Bouchi, Tokiyo Takagi, Masayuki Hatanaka, Komei Takeda, Shigeru Okuya, Wataru Nishimura, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Tetsuya Yamada, Yoshihiro Ogawa, Eiji Ikeda, Hiroaki Nagano, Yukio Tanizawa
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes. However, the pathophysiological significance in humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese sub
Externí odkaz:
https://doaj.org/article/92a308a1444447e78710fef4553a9fd9