Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Atsushi Kodan"'
Autor:
Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Matsuoka, Yasuhisa Kimura, Kazumitsu Ueda, Hiroaki Kato
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
P-glycoprotein, an ATP-binding cassette (ABC) transporter, extrudes a large variety of xenobiotics from the cell which protects tissues from toxins. Here authors solve a pair of X-ray structures of homodimeric P-glycoprotein and resolve structural el
Externí odkaz:
https://doaj.org/article/e070bd814c674886ba6ba882b1f3a452
Autor:
Keitaro Yamashita, Naoyuki Kuwabara, Takanori Nakane, Tomohiro Murai, Eiichi Mizohata, Michihiro Sugahara, Dongqing Pan, Tetsuya Masuda, Mamoru Suzuki, Tomomi Sato, Atsushi Kodan, Tomohiro Yamaguchi, Eriko Nango, Tomoyuki Tanaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Hiroshi Manya, Tamao Endo, Ryuichi Kato, Toshiya Senda, Hiroaki Kato, So Iwata, Hideo Ago, Masaki Yamamoto, Fumiaki Yumoto, Toru Nakatsu
Publikováno v:
IUCrJ, Vol 4, Iss 5, Pp 639-647 (2017)
Serial femtosecond crystallography (SFX) using X-ray free-electron lasers (XFELs) holds enormous potential for the structure determination of proteins for which it is difficult to produce large and high-quality crystals. SFX has been applied to vario
Externí odkaz:
https://doaj.org/article/6801e2bc89df4536aa7bf825ab1a4cbf
Autor:
Ryota Futamata, Kazumitsu Ueda, Hiroaki Kato, Noriyuki Kioka, Atsushi Kodan, Toru Nakatsu, Yasuhisa Kimura
Publikováno v:
FEBS Letters. 595:707-716
ABCB1, also called MDR1 or P-glycoprotein, exports various hydrophobic compounds and plays an essential role as a protective physiological barrier in several organs, including the brain, testis, and placenta. However, little is known about the struct
Autor:
Toru Nakatsu, Tomohiro Yamaguchi, Hiroaki Kato, Keita Matsuoka, Kazumitsu Ueda, Yasuhisa Kimura, Atsushi Kodan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
P-glycoprotein extrudes a large variety of xenobiotics from the cell, thereby protecting tissues from their toxic effects. The machinery underlying unidirectional multidrug pumping remains unknown, largely due to the lack of high-resolution structura
Publikováno v:
FEBS lettersReferences. 594(23)
ATP-binding cassette (ABC) proteins play diverse roles in all living organisms, making them an attractive model for evolution. Early evolution of ancestral unicellular organisms entailed the acquisition of at least three types of ABC proteins: type 1
Autor:
Ryota Futamata, Takafumi Ichikawa, Kazumitsu Ueda, Atsushi Kodan, Fumihiko Ogasawara, Yasuhisa Kimura, Noriyuki Kioka
Publikováno v:
J Biol Chem
P-glycoprotein (P-gp; also known as MDR1 or ABCB1) is an ATP-driven multidrug transporter that extrudes various hydrophobic toxic compounds to the extracellular space. P-gp consists of two transmembrane domains (TMDs) that form the substrate transloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9242c8199e5113e0d1ecaca2b37a74d
https://europepmc.org/articles/PMC7152753/
https://europepmc.org/articles/PMC7152753/
Autor:
Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Atsushi Kodan, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda
P-glycoprotein (P-gp; also known as MDR1 or ABCB1) is an ATP-driven multidrug transporter that extrudes various hydrophobic toxic compounds to the extracellular space. P-gp consists of two transmembrane domains (TMDs) that form the substrate transloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e689f9932e284ad8489d56b48b296e4
Publikováno v:
Nihon Kessho Gakkaishi. 56:224-229
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mutations in the Mpv17 gene are responsible for MPV17-related hepatocerebral mitochondrial DNA depletion syndrome and Charcot–Marie–Tooth (CMT) disease. Although several models including mouse, zebrafish, and cultured human cells, have b
Externí odkaz:
https://doaj.org/article/c389135b8ea44392a861d3886ca048e8
Publikováno v:
FEBS Journal. 276:3504-3516
Human P-glycoprotein (P-gp), which conveys multidrug resistance, is an ATP-dependent drug efflux pump that transports a wide variety of structurally unrelated compounds out of cells. P-gp possesses a ‘linker region’ of ∼ 75 amino acids that con