Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Atsushi Kimishima"'
Autor:
Waleed A Abdel-Naime, Atsushi Kimishima, Andi Setiawan, John Refaat Fahim, Mostafa A. Fouad, Mohamed Salah Kamel, Masayoshi Arai
Publikováno v:
Marine Drugs, Vol 18, Iss 11, p 555 (2020)
The tumor microenvironment is a nutrient-deficient region that alters the cancer cell phenotype to aggravate cancer pathology. The ability of cancer cells to tolerate nutrient starvation is referred to as austerity. Compounds that preferentially targ
Externí odkaz:
https://doaj.org/article/09f83d418a624b2b83ebc6c4a58e8681
Autor:
Tadafumi Fujita, Jianyu Lin, Atsushi Kimishima, Masayoshi Arai, Hirosato Takikawa, Yusuke Ogura
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 86:590-595
A concise synthesis of cajaninstilbene acid was achieved in 7 steps from (E)-3,5-dimethoxystilbene in 8.6% overall yield via the Claisen rearrangement of an aryl reverse-prenyl ether as the key step. Cytotoxic activities against human pancreatic carc
Publikováno v:
Organic & Biomolecular Chemistry. 20:5397-5401
A new single-step approach to a C3a acetoxy pyrroloindole from various indoles under hypervalent iodine and ammonium salt-mediated mild reaction conditions was developed. The described method enables the short-step synthesis of (−)-protubonine B.
Publikováno v:
Synlett. 32:1865-1868
An asymmetric formal synthesis of trichodermamides B and C was achieved in 15 steps based on a tyrosine ester chiral-pool approach. Key features of this synthesis include stereoselective construction of a cis-1,2-oxazadecaline core by an acid-mediate
Autor:
Kenta Ikoma, Michihiro Takahama, Atsushi Kimishima, Yixi Pan, Manabu Taura, Akiyoshi Nakayama, Masayoshi Arai, Naoki Takemura, Tatsuya Saitoh
Publikováno v:
International immunology. 34(10)
The human body is exposed to various particulates of industrial, environmental, or endogenous origin. Invading or intrinsic particulates can induce inflammation by aberrantly activating the immune system, thereby causing crystallopathies. When immune
Publikováno v:
Journal of Natural Medicines. 74:495-500
Cancer cells adapted to the microenvironment in tumor such as hypoxic and nutrient-starved conditions are now paid much attention as the therapeutic target of cancer. In the course of search for selective cytotoxic substances against cancer cells ada
Publikováno v:
Journal of Natural Medicines
The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nu
Autor:
Masayoshi Arai, Kazuo Harada, Yasumasa Hara, Atsushi Kimishima, Kazumasa Hirata, Takahiro Jomori, Andi Setiawan, Miho Sasaoka
Publikováno v:
Journal of Natural Medicines. 74:76-82
It is generally accepted that fungi have a number of dormant gene clusters for the synthesis of secondary metabolites, and the activation of these gene clusters can expand the diversity of secondary metabolites in culture. Recent studies have reveale
Autor:
John Refaat Fahim, Masayoshi Arai, Mostafa A. Fouad, Mohamed Kamel, Waleed A Abdel-Naime, Atsushi Kimishima, Andi Setiawan
Publikováno v:
Marine Drugs
Volume 18
Issue 11
Marine Drugs, Vol 18, Iss 555, p 555 (2020)
Volume 18
Issue 11
Marine Drugs, Vol 18, Iss 555, p 555 (2020)
The tumor microenvironment is a nutrient-deficient region that alters the cancer cell phenotype to aggravate cancer pathology. The ability of cancer cells to tolerate nutrient starvation is referred to as austerity. Compounds that preferentially targ
Autor:
Yukio Ago, Kazuki Bando, Satoshi Kawata, Kazuya Kikuchi, Masayoshi Arai, Kaoru Seiriki, Atsushi Kimishima, Katsumasa Fujita, Kazuo Harada, Masato Tanuma, Hitoshi Hashimoto, Atsushi Kasai, Naoyuki Kotoku, Masafumi Minoshima, Kosuke Higashino
Publikováno v:
JCI Insight
Detailed spatial information of low-molecular weight compound distribution, especially in the brain, is crucial to understanding their mechanism of actions. Imaging techniques that can directly visualize drugs in the brain at a high resolution will c