Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Atsushi Kaida"'
DNA damage response in a 2D-culture model by diffusing alpha-emitters radiation therapy (Alpha-DaRT)
Autor:
Hitomi Nojima, Atsushi Kaida, Yusuke Matsuya, Motohiro Uo, Ryo-ichi Yoshimura, Lior Arazi, Masahiko Miura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Diffusing alpha-emitters radiation therapy (Alpha-DaRT) is a unique method, in which interstitial sources carrying 224Ra release a chain of short-lived daughter atoms from their surface. Although DNA damage response (DDR) is crucial to induc
Externí odkaz:
https://doaj.org/article/8e4d42059e544b38a7a70b1dc14a8b94
Autor:
Hirofumi Tomioka, Naoto Nishii, Yu Oikawa, Takuma Kugimoto, Takeshi Kuroshima, Hideaki Hirai, Kou Kayamori, Atsushi Kaida, Masahiko Miura, Hiroyuki Harada
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23120- (2024)
Objective: The accurate assessment of the involvement of mandibular gingival squamous cell carcinoma (SCC) is essential for determining the extent of resection and is also useful for predicting lymph node metastasis and prognosis. The purpose of this
Externí odkaz:
https://doaj.org/article/24809d91f35640c18cfe42e5232958c8
Autor:
Shigeto Nishikawa, Atsushi Kaida, Alejandro Parrales, Atul Ranjan, Mohamed Alalem, Hongyi Ren, Frank J. Schoenen, David K. Johnson, Tomoo Iwakuma
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract Cancers are frequently addicted to oncogenic missense mutant p53 (mutp53). DNAJA1, a member of heat shock protein 40 (HSP40), also known as J-domain proteins (JDPs), plays a crucial role in the stabilization and oncogenic activity of misfold
Externí odkaz:
https://doaj.org/article/32dc6a9804484bb98536de5316509fc1
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Insulin-like growth factor binding protein-3 (IGFBP-3) is a member of the IGFBP family that has high affinity for IGFs and functions as either an oncogene or tumor suppressor in various types of cancer. We previously found that IGFBP3 mRNA l
Externí odkaz:
https://doaj.org/article/d5a92a584aee4f12ad2c8a7883bb61a9
Autor:
Atul Ranjan, Elizabeth A. Thoenen, Atsushi Kaida, Stephanie Wood, Terry Van Dyke, Tomoo Iwakuma
Publikováno v:
Cancers, Vol 15, Iss 18, p 4596 (2023)
MTBP is implicated in cell cycle progression, DNA replication, and cancer metastasis. However, the function of MTBP remains enigmatic and is dependent on cellular contexts and its cellular localization. To understand the in vivo physiological role of
Externí odkaz:
https://doaj.org/article/93329bfe790a48b3ab2764891b6dff11
Autor:
Kohei Okuyama, Keiji Suzuki, Tomofumi Naruse, Hiroki Tsuchihashi, Souichi Yanamoto, Atsushi Kaida, Masahiko Miura, Masahiro Umeda, Shunichi Yamashita
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is an efficient anti-tumor therapeutic agent that inhibits the activation of EGFR; however, data related to the cellular effects of prolonged cetuximab treatment
Externí odkaz:
https://doaj.org/article/e696f56cecc94299aeb6208f2e259997
Autor:
Daiki Kanbayashi, Takako Kurata, Hideyuki Kubo, Atsushi Kaida, Seiji P Yamamoto, Kazutaka Egawa, Yuki Hirai, Kazuma Okada, Ryo Ikemori, Takahiro Yumisashi, Akira Yamamoto, Hideki Yoshida, Takanori Hirayama, Kazuyoshi Ikuta, Kazushi Motomura
Publikováno v:
Western Pacific Surveillance and Response, Vol 11, Iss 2, Pp 48-50 (2021)
A large rubella epidemic is currently ongoing since 2018 in Osaka, Japan. The detected rubella viruses were classified into genotypes 1E lineage 2 and 2B lineage 1. These strains may have been imported from endemic countries, and these viruses spread
Externí odkaz:
https://doaj.org/article/7efc2e412e184a6d9ea497b72d9cb015
Autor:
Mohamed Alalem, Mrinalini Bhosale, Atul Ranjan, Satomi Yamamoto, Atsushi Kaida, Shigeto Nishikawa, Alejandro Parrales, Sana Farooki, Shrikant Anant, Subhash Padhye, Tomoo Iwakuma
Publikováno v:
Cancers, Vol 14, Iss 17, p 4187 (2022)
Accumulation of missense mutant p53 (mutp53) in cancers promotes malignant progression. DNAJA1, a member of HSP40 (also known as J-domain proteins: JDPs), is shown to prevent misfolded or conformational mutp53 from proteasomal degradation. Given freq
Externí odkaz:
https://doaj.org/article/97eb9b5e050e4e739494aaa192392950
Autor:
Kazuma Okada, Ryo Morita, Kazutaka Egawa, Yuki Hirai, Atsushi Kaida, Michinori Shirano, Hideyuki Kubo, Tetsushi Goto, Seiji P. Yamamoto
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 9, Pp 1782-1784 (2019)
The largest outbreak of dengue fever in Tanzania is ongoing. Dengue virus type 1 was diagnosed in a traveler who returned from Tanzania to Japan. In phylogenetic analysis, the detected strain was close to the Singapore 2015 strain, providing a valuab
Externí odkaz:
https://doaj.org/article/1855df3d7a9d445a92e5d29a2c7d8549
Autor:
Atsushi Kaida, Tomoo Iwakuma
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13527 (2021)
Heat shock proteins (HSPs) are molecular chaperones that assist diverse cellular activities including protein folding, intracellular transportation, assembly or disassembly of protein complexes, and stabilization or degradation of misfolded or aggreg
Externí odkaz:
https://doaj.org/article/47848b2cc53f44ccbb72c8ad4f2a31cf