Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Atsushi KASAI"'
Autor:
Leo Kojima, Kaoru Seiriki, Hiroki Rokujo, Takanobu Nakazawa, Atsushi Kasai, Hitoshi Hashimoto
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109878- (2024)
Summary: Adeno-associated virus (AAV) vectors are potential tools for cell-type-selective gene delivery to the central nervous system. Although cell-type-specific enhancers and promoters have been identified for AAV systems, there is limited informat
Externí odkaz:
https://doaj.org/article/5bb7caeff759477bb33339518032752c
Autor:
Masakazu Agetsuma, Issei Sato, Yasuhiro R. Tanaka, Luis Carrillo-Reid, Atsushi Kasai, Atsushi Noritake, Yoshiyuki Arai, Miki Yoshitomo, Takashi Inagaki, Hiroshi Yukawa, Hitoshi Hashimoto, Junichi Nabekura, Takeharu Nagai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Associative learning is crucial for adapting to environmental changes. Interactions among neuronal populations involving the dorso-medial prefrontal cortex (dmPFC) are proposed to regulate associative learning, but how these neuronal populat
Externí odkaz:
https://doaj.org/article/545692dfb8104c3fa738efd0053e7876
Autor:
Takashi Nagashima, Suguru Tohyama, Kaori Mikami, Masashi Nagase, Mieko Morishima, Atsushi Kasai, Hitoshi Hashimoto, Ayako M. Watabe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Feeding and stress are deeply related to each other, yet neural circuits how they interact are not fully understood. Here, the authors show that the parabrachial-to-parasubthalamic nucleus pathway is involved in fear-induced feeding suppression.
Externí odkaz:
https://doaj.org/article/1166a363c4d6474095d2ede7eedce4ae
Autor:
Masato Tanuma, Misaki Niu, Jin Ohkubo, Hiroki Ueno, Yuka Nakai, Yoshihisa Yokoyama, Kaoru Seiriki, Hitoshi Hashimoto, Atsushi Kasai
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-11 (2022)
Abstract We recently reported that a neuronal population in the claustrum (CLA) identified under exposure to psychological stressors plays a key role in stress response processing. Upon stress exposure, the main inputs to the CLA come from the basola
Externí odkaz:
https://doaj.org/article/086aa11252254f0981c6cba6fe5ff931
Autor:
Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by specific social symptoms, restricted interests, stereotyped repetitive behaviors, and delayed language development. The 3q29 microdeletion (3q29del), a recurre
Externí odkaz:
https://doaj.org/article/6e0ba469188045ff80ae72be14378861
Autor:
Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kaneko
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112149- (2023)
Summary: Major depressive disorder (MDD) is among the most common mental illnesses. Serotonergic (5-HT) neurons are central to the pathophysiology and treatment of MDD. Repeatedly recalling positive episodes is effective for MDD. Stimulating 5-HT neu
Externí odkaz:
https://doaj.org/article/0bf77f9fc9f948d28861c0f74f91766c
Autor:
Kana Yamamoto, Toshihiko Kuriu, Kensuke Matsumura, Kazuki Nagayasu, Yoshinori Tsurusaki, Noriko Miyake, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Mikiya Fujiwara, Masayuki Baba, Kohei Kitagawa, Tomoya Takemoto, Nanaka Gotoda-Nishimura, Tomohiro Takada, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Yukio Ago, Satoshi Kida, Kazuhiro Takuma, Fumihito Ono, Naomichi Matsumoto, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract An increasing body of evidence suggests that impaired synapse development and function are associated with schizophrenia; however, the underlying molecular pathophysiological mechanism of the disease remains largely unclear. We conducted a f
Externí odkaz:
https://doaj.org/article/8394ac62854447c697f5bccde4c28363
Autor:
Kohei Kitagawa, Kensuke Matsumura, Masayuki Baba, Momoka Kondo, Tomoya Takemoto, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by core symptoms of impaired social behavior and communication. Recent studies have suggested that the oxytocin system, which regulates social beh
Externí odkaz:
https://doaj.org/article/9784bfe823674a1b93f3436350088099
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-13 (2020)
Abstract Background In plants, the RNA silencing system functions as an antiviral defense mechanism following its induction with virus-derived double-stranded RNAs. This occurs through the action of RNA silencing components, including Dicer-like (DCL
Externí odkaz:
https://doaj.org/article/371f53b192704509908250148b44b29b
Autor:
Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase, Shinya Ayabe, Ikuko Yamada, Tamio Furuse, Hirotoshi Shibuya, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Kazuki Nagayasu, Kana Yamamoto, Kohei Kitagawa, Hiroki Miura, Nanaka Gotoda-Nishimura, Hisato Igarashi, Misuzu Hayashida, Masayuki Baba, Momoka Kondo, Shigeru Hasebe, Kosei Ueshima, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Tokuichi Iguchi, Makoto Sato, Shun Yamaguchi, Masaru Tamura, Shigeharu Wakana, Atsushi Yoshiki, Ayako M. Watabe, Hideyuki Okano, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
De novo mutations significantly contribute to autism spectrum disorders (ASD). Here, the authors demonstrate that ASD-associated de novo mutations in the POGZ gene, one of a high-confidence ASD gene, lead to ASD-related impaired neuronal development
Externí odkaz:
https://doaj.org/article/b3970c6881ab49c4a520b80ed0ce7f6e