Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Atsushi Furuta"'
Autor:
Atsushi Furuta, Tomoko Shima, Mihoko Kawaguchi, Akemi Yamaki-Ushijima, Ippei Yasuda, Sayaka Tsuda, Satoshi Yoneda, Kazuma Higashisaka, Shi-Bin Cheng, Kenji Matsumoto, Yasuo Tsutsumi, Surendra Sharma, Shigeru Saito, Akitoshi Nakashima
Publikováno v:
Reproductive Medicine, Vol 3, Iss 2, Pp 112-126 (2022)
Poor placentation is closely related with the etiology of preeclampsia and may impact fetal growth restriction. For placental developmental growth, we have demonstrated that dysregulation of autophagy, a key mechanism to maintain cellular homeostasis
Externí odkaz:
https://doaj.org/article/e9db575df0fb4cbaa099ada2a3493146
Autor:
Akitoshi Nakashima, Atsushi Furuta, Kiyotaka Yamada, Mihoko Yoshida-Kawaguchi, Akemi Yamaki-Ushijima, Ippei Yasuda, Masami Ito, Satoshi Yamashita, Sayaka Tsuda, Satoshi Yoneda, Shibin Cheng, Surendra Sharma, Tomoko Shima
Publikováno v:
Biology, Vol 12, Iss 3, p 373 (2023)
Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decades, this pr
Externí odkaz:
https://doaj.org/article/1090bb5a923542a882737a1dab49800f
Autor:
Akitoshi Nakashima, Tomoko Shima, Sayaka Tsuda, Aiko Aoki, Mihoko Kawaguchi, Atsushi Furuta, Ippei Yasuda, Satoshi Yoneda, Akemi Yamaki-Ushijima, Shi-Bin Cheng, Surendra Sharma, Shigeru Saito
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2432 (2021)
Aggrephagy is defined as the selective degradation of aggregated proteins by autophagosomes. Protein aggregation in organs and cells has been highlighted as a cause of multiple diseases, including neurodegenerative diseases, cardiac failure, and rena
Externí odkaz:
https://doaj.org/article/dfb33799a018408eb80c96376573eef6
Autor:
Atsushi Furuta, Masayoshi Tsubuki, Miduki Endoh, Tatsuki Miyamoto, Junichi Tanaka, Kazi Abdus Salam, Nobuyoshi Akimitsu, Hidenori Tani, Atsuya Yamashita, Kohji Moriishi, Masamichi Nakakoshi, Yuji Sekiguchi, Satoshi Tsuneda, Naohiro Noda
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 18439-18453 (2015)
Hepatitis C virus (HCV) is an important etiological agent of severe liver diseases, including cirrhosis and hepatocellular carcinoma. The HCV genome encodes nonstructural protein 3 (NS3) helicase, which is a potential anti-HCV drug target because its
Externí odkaz:
https://doaj.org/article/335ad083a37c4296872a1cb1855a34d0
Autor:
Kazi Abdus Salam, Atsushi Furuta, Naohiro Noda, Satoshi Tsuneda, Yuji Sekiguchi, Atsuya Yamashita, Kohji Moriishi, Masamichi Nakakoshi, Hidenori Tani, Sona Rani Roy, Junichi Tanaka, Masayoshi Tsubuki, Nobuyoshi Akimitsu
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4006-4020 (2014)
The helicase portion of the hepatitis C virus nonstructural protein 3 (NS3) is considered one of the most validated targets for developing direct acting antiviral agents. We isolated polybrominated diphenyl ether (PBDE) 1 from a marine sponge as an N
Externí odkaz:
https://doaj.org/article/eae347ac00ca414684d71b216c0593a4
Autor:
Atsushi Furuta, Kazi Abdus Salam, Idam Hermawan, Nobuyoshi Akimitsu, Junichi Tanaka, Hidenori Tani, Atsuya Yamashita, Kohji Moriishi, Masamichi Nakakoshi, Masayoshi Tsubuki, Poh Wee Peng, Youichi Suzuki, Naoki Yamamoto, Yuji Sekiguchi, Satoshi Tsuneda, Naohiro Noda
Publikováno v:
Marine Drugs, Vol 12, Iss 1, Pp 462-476 (2014)
Hepatitis C virus (HCV) is an important etiological agent that is responsible for the development of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV nonstructural protein 3 (NS3) helicase is a possible target for novel drug deve
Externí odkaz:
https://doaj.org/article/938becb12fd0415aa67046233a4f8b5f
Autor:
Naohiro Noda, Nobuyoshi Akimitsu, Yuji Sekiguchi, Satoshi Tsuneda, Masamichi Nakakoshi, Masayoshi Tsubuki, Nobuyuki Enomoto, Shinya Maekawa, Naoya Sakamoto, Nobuyuki Kato, Masanori Ikeda, Yuusuke Fujimoto, Hidenori Tani, Yoshihisa Fujita, Osamu Fujita, Yasuyoshi Matsuda, Atsushi Furuta, Kazi Abdus Salam, Atsuya Yamashita, Junichi Tanaka, Kohji Moriishi
Publikováno v:
Marine Drugs, Vol 10, Iss 4, Pp 744-761 (2012)
Hepatitis C virus (HCV) is a causative agent of acute and chronic hepatitis, leading to the development of hepatic cirrhosis and hepatocellular carcinoma. We prepared extracts from 61 marine organisms and screened them by an in vitro fluorescence ass
Externí odkaz:
https://doaj.org/article/edd9a598b9c4400bacd28c66ac07e9cd
Autor:
Yuusuke Fujimoto, Kazi Abdus Salam, Atsushi Furuta, Yasuyoshi Matsuda, Osamu Fujita, Hidenori Tani, Masanori Ikeda, Nobuyuki Kato, Naoya Sakamoto, Shinya Maekawa, Nobuyuki Enomoto, Nicole J de Voogd, Masamichi Nakakoshi, Masayoshi Tsubuki, Yuji Sekiguchi, Satoshi Tsuneda, Nobuyoshi Akimitsu, Naohiro Noda, Atsuya Yamashita, Junichi Tanaka, Kohji Moriishi
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48685 (2012)
Combination therapy with ribavirin, interferon, and viral protease inhibitors could be expected to elicit a high level of sustained virologic response in patients infected with hepatitis C virus (HCV). However, several severe side effects of this com
Externí odkaz:
https://doaj.org/article/d09c1071b1154cf6977a9ea8a2ce3cb6
Autor:
Yuji Sakahashi, Kazuma Higashisaka, Ryo Isaka, Rina Izutani, Jiwon Seo, Atsushi Furuta, Akemi Yamaki-Ushijima, Hirofumi Tsujino, Yuya Haga, Akitoshi Nakashima, Yasuo Tsutsumi
Publikováno v:
Nanotoxicology.
Opportunities for the exposure of pregnant women to engineered nanoparticles have been increasing with the expanding use of these materials. Therefore, there are concerns that nanoparticles could have adverse effects on the establishment and maintena
Autor:
Atsushi Furuta, Tomoko Shima, Mihoko Yoshida-Kawaguchi, Kiyotaka Yamada, Ippei Yasuda, Sayaka Tsuda, Akemi Yamaki-Ushijima, Satoshi Yoneda, Kazuma Higashisaka, Shi-Bin Cheng, Kenji Matsumoto, Yasuo Tsutsumi, Surendra Sharma, Shigeru Saito, Akitoshi Nakashima
Publikováno v:
Journal of reproductive immunology. 155
Inhibition of autophagy contributes to the pathophysiology of preeclampsia. Although chloroquine (CHQ) is an autophagy inhibitor, it can reduce the occurrence of preeclampsia in women with systemic lupus erythematosus. To clarify this important clini