Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Atsushi Akahane"'
Autor:
Takuya Maemoto, Miho Tada, Takuma Mihara, Noriko Ueyama, Hideaki Matsuoka, Katsuya Harada, Takayuki Yamaji, Kiyoharu Shirakawa, Satoru Kuroda, Atsushi Akahane, Akinori Iwashita, Nobuya Matsuoka, Seitaro Mutoh
Publikováno v:
Journal of Pharmacological Sciences, Vol 96, Iss 1, Pp 42-52 (2004)
Adenosine A1 receptors in the brain are believed to play an important role in brain functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazin
Externí odkaz:
https://doaj.org/article/860f43174114496499f11078d16d5768
Autor:
Ritsuko Matsuda, Yasuyuki Mitani, Atsushi Akahane, Kayoko Mihara, Nobuya Matsuoka, Akinori Iwashita, Satoshi Aoki, Hiroko Yamamoto, Junko Yarimizu, Takuma Mihara
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 323:708-719
Central adenosine A(2A) receptor is a promising target for drugs to treat Parkinson's disease (PD), and the central blockade of adenosine A(1) receptor improves cognitive function. In the present study, we investigated the effect of a novel adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae7339503b87ee32a988829f48721d7
https://doi.org/10.1124/jpet.107.121962
https://doi.org/10.1124/jpet.107.121962
Autor:
Kazuo Sakane, Satoru Kuroda, Hiromichi Itani, Atsushi Akahane, Fujiko Takamura, Yasuyo Tomishima, Yoshiyuki Tenda
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 49:988-998
A novel series of 3-(2-substituted-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridines (5—38) were synthesized and evaluated for their in vitro adenosine A1 and A2A receptor binding activities, and in vitro metabolism by rat liver in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a50230e34ef837d9d0c35589252c6b9c
https://doi.org/10.1248/cpb.49.988
https://doi.org/10.1248/cpb.49.988
Autor:
Kazuo Sakane, Atsushi Akahane, Satoru Kuroda, Takayoshi Kinoshita, Isao Nakanishi, Kieran Durkin, Shintaro Nishimura, Hiromichi Itani
Publikováno v:
Tetrahedron. 55:10351-10364
An efficient synthesis of FR166124 ( 1 ) was achieved through a novel sequential Horner-Emmons -isomerization reaction of cyclohexanone ( 2 ) with tert -butyl diethylphosphonoacetate ( 3 ) as the key process. Extensive studies of the key reaction ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4424a2ff994b49b2b7066d6421c9eba6
https://doi.org/10.1016/s0040-4020(99)00590-6
https://doi.org/10.1016/s0040-4020(99)00590-6
Autor:
Kazuo Sakane, Atsushi Akahane, Hiromichi Itani, Yoshiyuki Tenda, Satoru Kuroda, Kieran Durkin, Takayoshi Kinoshita, Shintaro Nishimura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1979-1984
Novel 3-(2-cycloalkyl and cycloalkenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazo lo [1,5-a]-pyridines were synthesized and evaluated for their adenosine A1 receptor binding activities. In this series, FR166124 (3) was found to be the most poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b10273269867cb4cc8540c957bb3e6
https://doi.org/10.1016/s0960-894x(99)00304-2
https://doi.org/10.1016/s0960-894x(99)00304-2
Autor:
Takao Terai, Takahiro Kusunoki, Takafumi Mitsunaga, Takeshi Kato, Youichi Shiokawa, Atsushi Akahane, Keizo Yoshida, Yasuhiro Kita, Takayoshi Kinoshita, Hirohito Katayama
Publikováno v:
Journal of Medicinal Chemistry. 42:779-783
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59285ff596b2adffc31fa677c3ff550
https://doi.org/10.1021/jm980671w
https://doi.org/10.1021/jm980671w
Autor:
Michael A. Gonzalez, Atsushi Akahane, Guy Milot, Vladimir Struzka, Albert I. Meyers, Joseph S. Warmus
Publikováno v:
Tetrahedron Letters. 38:4195-4198
Attempts to repeat the spirocyclization of isoquinoline carboxylic acids, 4, 5, 8, and 9 to the spiroketones, 6 led only to the formation of the N-carboxyanhydrides, 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b3616dec305dc2353f4d900b144aa79
https://doi.org/10.1016/s0040-4039(97)00869-1
https://doi.org/10.1016/s0040-4039(97)00869-1
Autor:
Youichi Shiokawa, Takafumi Mitsunaga, Atsushi Akahane, Keizo Yoshida, Takahiro Kusunoki, Takao Terai, Hirohito Katayama, Yasuhiro Kita
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2059-2062
Novel 2-phenylpyrazolo[1,5-a]pyridine-3-acryloylamides were synthesized and evaluated for diuretic activities. FK453 (1d), the most potent compound in this series, was found to be a potent and selective adenosine A1 receptor antagonist, whereas 1e, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5205eea4a5ee052781455fbdad50b91d
https://doi.org/10.1016/0960-894x(96)00368-x
https://doi.org/10.1016/0960-894x(96)00368-x
Autor:
Takeshi Andoh, Takao Terai, Yasuhiro Kita, Haruo Horiai, Atsushi Akahane, Takahiro Kusunoki, Youichi Shiokawa, Keizo Yoshida, Itzuo Nagatomi
Publikováno v:
Drug Development Research. 36:25-34
The renal effects of FK453, a potent and selective non-xanthine adenosine A 1 receptor antagonist, were examined and compared with FR113452 (less active enantiomer of FK453), typical adenosine receptor antagonists, and diuretics. In rats FK453 posses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62bef2dd289f65594e6f92d670e269a9
https://doi.org/10.1002/ddr.430360105
https://doi.org/10.1002/ddr.430360105
Autor:
Albert I. Meyers, Joseph S. Warmus, Vladimir Struzka, Joseph Guiles, Michael A. Gonzalez, Atsushi Akahane
Publikováno v:
ChemInform. 23
Use of a modified auxiliary allowed for the asymmetric synthesis of quaternary carbons adjacent to nitrogen in tetrahydroisoquinolines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bc74ea66b222509f69dc515abbd14f1
https://doi.org/10.1002/chin.199225180
https://doi.org/10.1002/chin.199225180