Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Atsushi, Kawase"'
Autor:
Atsushi Kawase, Taihei Chuma, Kota Irie, Akira Kazaoka, Asuka Kakuno, Naoya Matsuda, Hiroaki Shimada, Masahiro Iwaki
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 10, Iss , Pp 100188- (2021)
Uptake transporters in brain microvascular endothelial cells (BMECs) are involved in the penetration of basic (cationic) drugs such as diphenhydramine (DPHM) into the brain. Lipopolysaccharide (LPS)-induced inflammation alters the expression levels a
Externí odkaz:
https://doaj.org/article/a72e23a5abc944ba83a0275649a008b8
Autor:
Hiroaki Shimada, Yuichi Urabe, Yuhei Okamoto, Zheng Li, Atsushi Kawase, Toshio Morikawa, Pengfei Tu, Osamu Muraoka, Masahiro Iwaki
Publikováno v:
Journal of Functional Foods, Vol 39, Iss , Pp 91-95 (2017)
Echinacoside (ECH) and acteoside (ACT), the major constituents of Cistanche tubulosa, suppress the increase in postprandial blood glucose level. Although ECH and ACT have been reported to weakly inhibit α-glucosidases, the underlying mechanism remai
Externí odkaz:
https://doaj.org/article/f0974283c15b499d9c9ec4836a80de66
Autor:
Hiroyuki Ikuta, Hiroaki Shimada, Kenjiro Sakamoto, Rena Nakamura, Atsushi Kawase, Masahiro Iwaki
Publikováno v:
Xenobiotica. 52:653-660
Acyl glucuronides (AGs) are known as one of the causes of idiosyncratic drug toxicity (IDT). Although AGs can be enzymatically hydrolysed by β-glucuronidase and esterase, much information on their characteristics and species differences is lacking.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d340962d3c9f74d0f5f2cce160b9fc5
https://doi.org/10.1080/00498254.2022.2131484
https://doi.org/10.1080/00498254.2022.2131484
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 22, Iss 1 (2019)
Purpose: The plasma membrane localization and transport activity of multidrug resistance-associated protein 2 (MRP2/ABCC2) and P-glycoprotein (P-gp/ABCB1) efflux transporters are governed by transporter-associated proteins. Phosphatidylinositol 4,5-b
Externí odkaz:
https://doaj.org/article/3aaf5c26d6c9461cadeaad80dfd0b83e
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 22, Iss 1 (2019)
Purpose: Bile duct ligation (BDL) in experimental animals is widely used as an animal model of liver cholestasis and fibrosis. The transcriptional process and plasma membrane localization of transporters are regulated by nuclear receptors and scaffol
Externí odkaz:
https://doaj.org/article/10ca65cbf5f24fefb382efbbf6380910
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 22, Iss 1 (2019)
Hepatic clearance (CLh) of carvedilol (CAR), which is eliminated via stereoselective metabolism by the CYP2D subfamily of cytochromes P450 (CYPs), was predicted using liver microsomes and hepatocytes from Sprague-Dawley (SD) rats and CYP2D-deficient
Externí odkaz:
https://doaj.org/article/b15b1b97ce6c4654ada5dd4eef6ce56f
Autor:
Atsushi Kawase, Miho Hirosoko, Yuka Sugihara, Yunosuke Koyama, Ayaka Fukae, Hiroaki Shimada, Masahiro Iwaki
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 239 (2021)
As increased expression and activities of efflux transporters (ETs) often cause drug resistance in cancers, we tried modulating ET activity in cancer cells, using scaffold proteins such as ezrin/radixin/moesin (ERM) proteins, and Na+/H+ exchanger reg
Externí odkaz:
https://doaj.org/article/e94744e167d04e9c8d7a823938d23b5e
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 11, Iss 5, Pp 662-667 (2016)
Phenytoin (5,5-diphenylhydantoin; DPH) induces expression of cytochromes P450 (CYPs). Interactions between DPH and tacrolimus suggested that the persistence of CYP induction after discontinuation of DPH is dependent on the history of administration a
Externí odkaz:
https://doaj.org/article/3ae58a5d999745c9a0171c1e85bcbce2
Autor:
Ken-ichi Oba, Hiroaki Shimada, Ryota Hashimoto, Atsushi Kawase, Takeo Nakanishi, Masahiro Iwaki
Publikováno v:
Endocrine Regulations. 56:22-30
Objective. Carbamazepine (CBZ), a widely used antiepileptic drug, is one major cause of the idiosyncratic liver injury along with immune reactions. Conversely, prostaglandin E2 (PGE2) demonstrates a hepatoprotective effect by regulating immune reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97f55f61a234b5a0577812fdd122e12
https://doi.org/10.2478/enr-2022-0003
https://doi.org/10.2478/enr-2022-0003
Autor:
Hiroyuki Mizuguchi, Toshiyoshi Fujiwara, Takao Hayakawa, Masahiro Iwaki, Atsushi Kawase, Kenji Kawabata, Hayato Matsui, Katsuhisa Tashiro, Kazufumi Katayama, Fuminori Sakurai, Kumiko Sugio
Purpose: Oncolytic adenoviruses (Ad) have been actively pursued as potential agents for cancer treatment. Among the various types of oncolytic Ads, the telomerase-specific replication-competent Ad (TRAD), which possesses an E1 gene expression cassett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f51268d0a141640cd15c44ec0099801
https://doi.org/10.1158/1078-0432.c.6519299
https://doi.org/10.1158/1078-0432.c.6519299
