Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Atsushi, KUWAHARA"'
Autor:
Kenji Watari, Suguru Yamasaki, Hung-Ya Tu, Masayuki Shikamura, Tatsuya Kamei, Hideki Adachi, Tomoaki Tochitani, Yasuyuki Kita, Aya Nakamura, Kazuki Ueyama, Keiichi Ono, Chikako Morinaga, Take Matsuyama, Junki Sho, Miyuki Nakamura, Masayo Fujiwara, Yoriko Hori, Anna Tanabe, Rina Hirai, Orie Terai, Osamu Ohno, Hidetaka Ohara, Tetsuya Hayama, Atsushi Ikeda, Daiki Nukaya, Keizo Matsushita, Masayo Takahashi, Akiyoshi Kishino, Toru Kimura, Shin Kawamata, Michiko Mandai, Atsushi Kuwahara
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Toward tissue/organoid transplantation therapy, a quality control method for human iPSC-derived retinal sheet is presented, and its therapeutic potential is demonstrated in preclinical safety and efficacy studies.
Externí odkaz:
https://doaj.org/article/93ae755e4a2047b8b1b8361673a47346
Autor:
Suguru Yamasaki, Atsushi Kuwahara, Akiyoshi Kishino, Toru Kimura, Masayo Takahashi, Michiko Mandai
Publikováno v:
Regenerative Therapy, Vol 19, Iss , Pp 24-34 (2022)
Background: The BMP signaling pathway plays a key role in growth, differentiation and patterning during neural development. Recent work on the generation of a self-organization of three-dimensional retinal organoid (3D-retina) from human pluripotent
Externí odkaz:
https://doaj.org/article/11b176d2bbb847c793f586af8d014255
Autor:
Hiroo Sasaki, Hidetaka Suga, Kazuhito Takeuchi, Yuichi Nagata, Hideyuki Harada, Tatsuma Kondo, Eiji Ito, Sachi Maeda, Mayu Sakakibara, Mika Soen, Tsutomu Miwata, Tomoyoshi Asano, Hajime Ozaki, Shiori Taga, Atsushi Kuwahara, Tokushige Nakano, Hiroshi Arima, Ryuta Saito
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe pituitary gland, regulating various hormones, is central in the endocrine system. As spontaneous recovery from hypopituitarism is rare, and exogenous-hormone substitution is clumsy, pituitary replacement via regenerative medicine, usi
Externí odkaz:
https://doaj.org/article/fa3826946c674bf6a78055b9986694d5
Autor:
Yu Kodani, Miho Kawata, Hidetaka Suga, Takatoshi Kasai, Chikafumi Ozone, Mayu Sakakibara, Atsushi Kuwahara, Shiori Taga, Hiroshi Arima, Toshiki Kameyama, Kanako Saito, Akira Nakashima, Hiroshi Nagasaki
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Human stem cell-derived organoid culture enables the in vitro analysis of the cellular function in three-dimensional aggregates mimicking native organs, and also provides a valuable source of specific cell types in the human body. We previously estab
Externí odkaz:
https://doaj.org/article/6d84c1aec77242b3aa42565dba602393
Autor:
Suguru Yamasaki, Hung-Ya Tu, Take Matsuyama, Matsuri Horiuchi, Tomoyo Hashiguchi, Junki Sho, Atsushi Kuwahara, Akiyoshi Kishino, Toru Kimura, Masayo Takahashi, Michiko Mandai
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103657- (2022)
Summary: Pluripotent stem cell (PSC)-derived retinal sheet transplanted in vivo can form structured photoreceptor layers, contact with host bipolar cells, and transmit light signals to host retinas. However, a major concern is the presence of graft b
Externí odkaz:
https://doaj.org/article/f2cca607881b4837bbc6d9a9d51e2a11
Autor:
Hung-Ya Tu, Takehito Watanabe, Hiroshi Shirai, Suguru Yamasaki, Masaharu Kinoshita, Keizo Matsushita, Tomoyo Hashiguchi, Hirotaka Onoe, Take Matsuyama, Atsushi Kuwahara, Akiyoshi Kishino, Toru Kimura, Mototsugu Eiraku, Kiyoshi Suzuma, Takashi Kitaoka, Masayo Takahashi, Michiko Mandai
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 562-574 (2019)
Background: We have previously reported that xeno-transplanted human ESC-derived retinas are able to mature in the immunodeficient retinal degeneration rodent models, similar to allo-transplantations using mouse iPSC-derived retina. The photoreceptor
Externí odkaz:
https://doaj.org/article/9426142104d94319966b4aa705aca802
Autor:
Satoshi Iraha, Hung-Ya Tu, Suguru Yamasaki, Takahiro Kagawa, Motohito Goto, Riichi Takahashi, Takehito Watanabe, Sunao Sugita, Shigenobu Yonemura, Genshiro A. Sunagawa, Take Matsuyama, Momo Fujii, Atsushi Kuwahara, Akiyoshi Kishino, Naoshi Koide, Mototsugu Eiraku, Hidenobu Tanihara, Masayo Takahashi, Michiko Mandai
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1059-1074 (2018)
Summary: Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies. Here, we established two mouse models of end-stage retinal degeneration with immunodef
Externí odkaz:
https://doaj.org/article/fa518bf2e7cc40a39d80e76bea362d35
Autor:
Atsushi Kuwahara, Misae Nazuka, Yuri Kuroki, Kohei Ito, Shunsuke Watanabe, Izumi Kumagai, Ryutaro Asano
Publikováno v:
Bioengineered; Dec2023, Vol. 14 Issue 1, p1-15, 15p
Publikováno v:
長崎国際大学論叢 = Nagasaki International University Review. 19:185-190
2015年に日本で承認された新医療用製剤に対し、安定性試験の現状を調査した。我々は、2015年に安定性試験の記述がある81の新医療用製剤を特定した。長期保存試験としては、5製剤が30±2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::17d94df2968867f0247891ecdc28dae7
http://id.nii.ac.jp/1171/00001501/
http://id.nii.ac.jp/1171/00001501/
Autor:
Atsushi Kuwahara, Hiroshi Sakai, Yuanjiang Xu, Yasuhiro Itoh, Yusuke Hirabayashi, Yukiko Gotoh
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e94408 (2014)
During mouse neocortical development, the Wnt-β-catenin signaling pathway plays essential roles in various phenomena including neuronal differentiation and proliferation of neural precursor cells (NPCs). Production of the appropriate number of neuro
Externí odkaz:
https://doaj.org/article/12ac6a25b7bb462b87318339e1d1d35d