Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cortex

Autor: Andrea Ghisleni, Mayte Bonilla-Quintana, Michele Crestani, Atsushi Fukuzawa, Padmini Rangamani, Nils Gauthier

Publikováno v: bioRxiv

The cell cortex is a dynamic assembly that ensures cell integrity during passive deformation or active response by adapting cytoskeleton topologies with poorly understood mechanisms. The spectrin meshwork ensures such adaptation in erythrocytes and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3119ce301033ce7d14c70a6c51afb897
https://doi.org/10.1101/2023.01.02.522381

The organisation of titin at the centre of the vertebrate striated muscle thick filament

Autor: Pauline Bennett, Martin Rees, Sarah Grover, Atsushi Fukuzawa, Alexander Alexandrovich, Roberto Steiner, Mathias Gautel

Publikováno v: Biophysical Journal. 122:28a-29a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2b433535240870529b619c53c495b0f
https://doi.org/10.1016/j.bpj.2022.11.375

Making sense of missense variants in TTN-related congenital myopathies

Autor: Anna Sarkozy, Erik-Jan Kamsteeg, Mark Pfuhl, Nicol C. Voermans, Martin Rees, Corrie E. Erasmus, Hülya-Sevcan Daimagüler, Steven A. Moore, Rahul Phadke, Mark R. Holt, Rolf Schröder, Istvan Bodi, Carla Grosmann, Sebahattin Cirak, E. Matthews, Ay Lin Kho, Peter Van den Bergh, Christian Thiel, Shane McKee, Joel Victor Fluss, Roksana Nikoopour, Charu Deshpande, Jens Reimann, Emily C. Oates, Maria Elena Farrugia, Özkan Özdemir, Isabelle Richard, Cristina Domínguez-González, Chaminda Konersman, Ekkehard Wilichowski, Birgit Brandmeier, Atsushi Fukuzawa, Ana Ferreiro, Heinz Jungbluth, Ros Quinlivan, Sandya Tirupathi, Mathias Gautel, Gabriele Dekomien, Cheryl Longman, Miguel A Fernandez-Garcia, Francesco Muntoni, Michael G. Hanna, Elizabeth Wraige, Elke Hobbiebrunken, Sarah Grover

Publikováno v: Acta Neuropathologica, 141, 431-453
Acta Neuropathologica, Vol. 141, no. 3, p. 431-453 (2021)
Acta Neuropathologica, 141, 3, pp. 431-453
Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2021, 141 (3), pp.431-453. ⟨10.1007/s00401-020-02257-0⟩
Acta Neuropathologica, 2021, 141 (3), pp.431-453. ⟨10.1007/s00401-020-02257-0⟩

Mutations in the sarcomeric protein titin, encoded byTTN, are emerging as a common cause of myopathies. The diagnosis of aTTN-related myopathy is, however, often not straightforward due to clinico-pathological overlap with other myopathies and the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50b0834b2069a16869cd3b6e7cc432f
http://hdl.handle.net/2066/231686

Binding partners of the kinase domains inDrosophilaobscurin and their effect on the structure of the flight muscle

Autor: Anja Katzemich, John C. Sparrow, Ryan J. H. West, Belinda Bullard, Sean T. Sweeney, Atsushi Fukuzawa, Mathias Gautel

Publikováno v: Journal of Cell Science.

Drosophila obscurin (Unc-89) is a titin-like protein in the M-line of the muscle sarcomere. Obscurin has two kinase domains near the C-terminus, both of which are predicted to be inactive. We have identified proteins binding to the kinase domains. Ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360f66d84235dca41ab4c1568bd21e33
https://doi.org/10.1242/jcs.170639

[Untitled]

Autor: Koscak Maruyama, Atsushi Fukuzawa, Naoto Yonezawa, Makio Tokunaga, Michio Hiroshima, Sumiko Kimura

Publikováno v: Journal of Muscle Research and Cell Motility. 23:449-453

Invertebrate connectin (I-connectin) is a 1960 kDa elastic protein linking the Z line to the tip of the myosin filament in the giant sarcomere of crayfish claw closer muscle (Fukuzawa et al., 2001 EMBO J 20: 4826–4835). I-Connectin can be extended

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7873221b268dcecc3317ab17ff2c8775
https://doi.org/10.1023/a:1023406422275