Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Atsuo Tamura"'
Autor:
Shota Nakagawa, Minami Kurokawa, Ohki Kambara, Toshiaki Takei, Kengo Daidoji, Akira Naito, Mao Takita, Akihiro Kawamoto, Mika Hirose, Atsuo Tamura
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1111 (2024)
The 21-residue peptide α3, which is artificially designed and consists of three repeats of 7 residues, is known to rapidly assemble into the α-helix nanofiber. However, its molecular structure within the fiber has not yet been fully elucidated. Thu
Externí odkaz:
https://doaj.org/article/c7f45a1d652f455d9cf5dc377e320ca1
Autor:
Yuki Yoshikawa, Keisuke Yuzu, Naoki Yamamoto, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Tetsushi Iwasaki, Masatomo So, Yuji Goto, Atsuo Tamura, Eri Chatani
Publikováno v:
Molecules, Vol 27, Iss 13, p 3964 (2022)
Amyloid fibrils have been an important subject as they are involved in the development of many amyloidoses and neurodegenerative diseases. The formation of amyloid fibrils is typically initiated by nucleation, whereas its exact mechanisms are largely
Externí odkaz:
https://doaj.org/article/38b66ab5c6674483a5ad5271480a0da0
Autor:
Kenta Morita, Kanon Nishimura, Shota Yamamoto, Natsumi Shimizu, Tomoko Yashiro, Ryoko Kawabata, Takashi Aoi, Atsuo Tamura, Tatsuo Maruyama
Publikováno v:
JACS Au. 2(9):2023-2028
Cell-selective killing using molecular self-assemblies is an emerging concept for cancer therapy. Reported molecular self-assemblies are triggered by hydrolysis of well-designed molecules inside or outside cancer cells. This hydrolysis can occur in c
Autor:
Sayuki Kanemitsu, Kenta Morita, Yudai Tominaga, Kanon Nishimura, Tomoko Yashiro, Haruka Sakurai, Yumemi Yamamoto, Ikuo Kurisaki, Shigenori Tanaka, Masaki Matsui, Tooru Ooya, Atsuo Tamura, Tatsuo Maruyama
Publikováno v:
Journal of Physical Chemistry B. 126(31):5793-5802
We investigated d-amino acids as potential inhibitors targeting l-peptide toxins. Among the l- and d-amino acids tested, we found that d-tryptophan (d-Trp) acted as an inhibitor of melittin-induced hemolysis. We then evaluated various Trp derivatives
Autor:
Tatsuo Maruyama, Sayuki Kanemitsu, Shota Yamamoto, Yuki Nishida, Atsuo Tamura, Takashi Aoi, Tomoyuki Morimoto, Kenta Morita, Kanon Nishimura
Publikováno v:
Biomacromolecules. 22:2524-2531
Self-assembly of synthetic molecules has been drawing broad attention as a novel emerging approach in drug discovery. Here, we report selective cell death induced by a novel peptide amphiphile that self-assembles to form entangled nanofibers (hydroge
Publikováno v:
ACS applied bio materials. 4(3)
It is known that tumor cells have a lower pH compared to normal cells. We have designed peptides that have no definite structure at neutral pH but at lower pH penetrate into the cell membrane by forming an α-helix structure and thus damage tumor cel
Publikováno v:
Biochemistry. 58(24)
Abnormal protein aggregation tends to result in the formation of β-sheet rich amyloid fibrils, which are related to various kinds of amyloidoses and neurodegenerative diseases. The susceptibility to aggregation of protein molecules is dealt with by
Publikováno v:
The Journal of Physical Chemistry B. 120:4743-4755
We have performed dielectric spectral measurements of lysozyme in a solid state to understand the effects of hydration and thermal excitation on the low-frequency dynamics of protein. Dielectric measurements were performed under changing hydration co
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Non-fibrillar protein aggregates that appear in the earlier stages of amyloid fibril formation are sometimes considered to play a key role in amyloid nucleation; however, the structural features of these aggregates currently remain unclear. We herein
Publikováno v:
The Journal of Physical Chemistry B. 119:9359-9368
We have studied temperature and hydration dependent low-frequency spectra of lipid bilayers of 1,2-dimyristoyl-sn-glycero-3-phosphoryl-3'-rac-glycerol (DMPG) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) by terahertz time-domain spectroscopy