Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Atsuo Ohike"'
Autor:
Kazutaka Higaki, Toshikiro Kimura, Nobuyuki Tanaka, Keiji Imai, Kazuto Okimoto, Satoshi Ueda, Rinta Ibuki, Yuji Tokunaga, Atsuo Ohike
Publikováno v:
Journal of Controlled Release. 108:386-395
The goal of this study is to develop a novel sustained-release (SR) system for poorly water-soluble drugs by applying solid dispersion (SD) technique for improving the solubility. The developed SR system, disintegration-controlled matrix tablet (DCMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7dda56c34567d0ff53e97041b01137
https://doi.org/10.1016/j.jconrel.2005.08.024
https://doi.org/10.1016/j.jconrel.2005.08.024
Autor:
Atsuo Ohike, Hiromitsu Yoshida, Rinta Ibuki, Yuji Tokunaga, Yoshiaki Kawashima, Toshiomi Nakate
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 56:319-325
FK224 is a cyclopeptide drug with poor oral absorption due to proteolysis in the gastrointestinal tract. The objectives of this study were to investigate the absorption of FK224 from the lung in healthy volunteers, and compare the pharmacokinetic pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72654e42d19a402b380d49a39fb120a
https://doi.org/10.1016/s0939-6411(03)00113-9
https://doi.org/10.1016/s0939-6411(03)00113-9
Publikováno v:
Journal of Pharmaceutical Sciences. 91:719-729
The objective of this study is to investigate the role of P-glycoprotein (P-gp), a membrane efflux pump associated with multidrug resistance (MDR) and a known substrate for tacrolimus, in determining the regional intestinal permeability of tacrolimus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46032c828b3f9fd4d8eda6383d2aa360
https://doi.org/10.1002/jps.10041
https://doi.org/10.1002/jps.10041
Autor:
Atsuo Ohike, Valentino J. Stella, Roger A. Rajewski, Rinta Ibuki, Osamu Aoki, Tetsumi Irie, Kaneto Uekama, Kazuto Okimoto, Norio Ohnishi
Publikováno v:
Journal of Controlled Release. 60:311-319
Purpose: The purpose of this study was to define membrane controlling factors responsible for drug release from a controlled-porosity osmotic pump tablet (OPT) that utilizes a sulfobutyl ether-β-cyclodextrin, (SBE)7m-β-CD, as both a solubilizing an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2f141dc7ec99f0f489adb419d69528
https://doi.org/10.1016/s0168-3659(99)00077-2
https://doi.org/10.1016/s0168-3659(99)00077-2
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:1734-1739
In the wet granulation process with a high speed mixer, the fast Fourier transform (hereinafter FFT) technique with a personal computer was adopted to perform concurrent precise analysis of the vibration to monitor the granulation process. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1273e24601678044989f659305ce85a9
https://doi.org/10.1248/cpb.47.1734
https://doi.org/10.1248/cpb.47.1734
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:1977-1982
A granulation experiment was conducted using different granulator and formulation. The purpose of the experiment was to clarify the granulation end-point to gain high yields of spherical, well-compacted granules and fine granules, and to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04649d03895f5a5016541955a4f22ac8
https://doi.org/10.1248/cpb.38.1977
https://doi.org/10.1248/cpb.38.1977
Autor:
Shinji Yamashita, Shigeki Tamura, Yuji Tokunaga, Atsuo Ohike, Rinta Ibuki, Hitoshi Sezaki, Gordon L. Amidon
Publikováno v:
Drug metabolism and pharmacokinetics. 19(3)
The objective of this study is to evaluate the effect of acute renal or hepatic failure on the intestinal absorption of tacrolimus. Simultaneous perfusion study in rat small intestine revealed that the extent of absorption into blood vessels was decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a532caf097b34bfbbf1abdcfef6c055
https://pubmed.ncbi.nlm.nih.gov/15499186
https://pubmed.ncbi.nlm.nih.gov/15499186
Autor:
Yoshiaki Kawashima, Hiromitsu Yoshida, Toshiomi Nakate, Yuji Tokunaga, Rinta Ibuki, Atsuo Ohike
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 59(1)
FK888 is a candidate selective NK1 receptor antagonist, and it exhibits poor absorption from the gastrointestinal tract in healthy volunteers. In a previous study, the optimized dry powder inhaler (DPI) formulation with carrier lactose using the Spin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ea16ef287022b9ff01e26532a1d500
https://pubmed.ncbi.nlm.nih.gov/15567298
https://pubmed.ncbi.nlm.nih.gov/15567298
Autor:
Toshiomi Nakate, Kazutaka Higaki, Kazuto Okimoto, Kazunari Yamashita, Rinta Ibuki, Toshikiro Kimura, Yuji Tokunaga, Atsuo Ohike
Publikováno v:
International journal of pharmaceutics. 267(1-2)
The aim of this study was to establish a new preparation method for solid dispersion formulation (SDF) of tacrolimus, a poorly water-soluble drug, without dichloromethane, because no use of dichloromethane is recommended by ICH harmonized tripartite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a47f39784016f458975af53841767c8
https://pubmed.ncbi.nlm.nih.gov/14602386
https://pubmed.ncbi.nlm.nih.gov/14602386
Autor:
Atsuo Ohike, Yuji Tokunaga, Toshiomi Nakate, Rinta Ibuki, Hiromitsu Yoshida, Yoshiaki Kawashima
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 97(1)
(4 R )-4-Hydroxy-l-[(l-methyl-l H -indol-3-yl)carbonyl]- l -prolyl- N -benzyl- N -methyl-3-(2-naphthyl)- l -alaninamide (FK888) is a candidate selective NK1 receptor antagonist, and it exhibits poor absorption from the gastrointestinal (GI) tract in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe13038c09616887f94a758ca95f2d8
https://pubmed.ncbi.nlm.nih.gov/15147801
https://pubmed.ncbi.nlm.nih.gov/15147801