Zobrazeno 1 - 10
of 461
pro vyhledávání: '"Atsuo OGURA"'
Autor:
Michiko Hirose, Kimiko Inoue, Shogo Matoba, Takaki Tatebe, Syun Tokita, Yukiko Dodo, Toshiko Tomishima, Ayumi Hasegawa, Arata Honda, Mao Ozaki, Akiko Shinogi, Ryoko Yanagisawa, Muhammad Fauzi, Takaaki Murakami, Nobuya Inagaki, Masaru Tamura, Atsuo Ogura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Because of the advent of genome-editing technology, gene knockout (KO) hamsters have become attractive research models for diverse diseases in humans. This study established a new KO model of diabetes by disrupting the insulin receptor subst
Externí odkaz:
https://doaj.org/article/01d7ed5f92ba44c797b3c246c9dc6450
Autor:
Keiji Mochida, Kohtaro Morita, Yoshio Sasaoka, Kento Morita, Hitoshi Endo, Ayumi Hasegawa, Masahide Asano, Atsuo Ogura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Rats are multiparous rodents that have been used extensively in research; however, the low reproductive performance of some rat strains hampers the broader use of rats as a biomedical model. In this study, the possibility of increasing the l
Externí odkaz:
https://doaj.org/article/34a4c487644244eaa395e176efe318de
Autor:
Youjia Guo, Tomohiro Kitano, Kimiko Inoue, Kensaku Murano, Michiko Hirose, Ten D Li, Akihiko Sakashita, Hirotsugu Ishizu, Narumi Ogonuki, Shogo Matoba, Masayuki Sato, Atsuo Ogura, Haruhiko Siomi
Publikováno v:
eLife, Vol 13 (2024)
Once fertilized, mouse zygotes rapidly proceed to zygotic genome activation (ZGA), during which long terminal repeats (LTRs) of murine endogenous retroviruses with leucine tRNA primer (MERVL) are activated by a conserved homeodomain-containing transc
Externí odkaz:
https://doaj.org/article/0ffdbabc0b19457a84163e814ca434b8
Autor:
Teruhiko WAKAYAMA, Atsuo OGURA
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 2, Pp i-iv (2024)
Externí odkaz:
https://doaj.org/article/a2365f6b3bc7436397dd8366e211e1dc
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Wild-derived mouse strains have been extensively used in biomedical research because of the high level of inter-strain polymorphisms and phenotypic variations. However, they often show poor reproductive performance and are difficult to maint
Externí odkaz:
https://doaj.org/article/8ff3cfc8979e4199a96d2e0be871d59e
Autor:
Aya Uchida, Kenya Imaimatsu, Honoka Suzuki, Xiao Han, Hiroki Ushioda, Mami Uemura, Kasane Imura-Kishi, Ryuji Hiramatsu, Hinako M. Takase, Yoshikazu Hirate, Atsuo Ogura, Masami Kanai-Azuma, Akihiko Kudo, Yoshiakira Kanai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
A valve-like structure called this Sertoli valve (SV) supports spermatogenesis by modulating the directional fluid flow in mouse testis. The SV formation is supported by its neighboring SOX17 + rete testis (RT). This study highlights the essential ro
Externí odkaz:
https://doaj.org/article/d684a74afeee4977a47f1576a9957d2e
Autor:
Erika HAYASHI, Sayaka WAKAYAMA, Daiyu ITO, Ayumi HASEGAWA, Keiji MOCHIDA, Masatoshi OOGA, Atsuo OGURA, Teruhiko WAKAYAMA
Publikováno v:
The Journal of Reproduction and Development, Vol 68, Iss 2, Pp 118-124 (2022)
Mammalian embryos are most commonly cryopreserved in liquid nitrogen; however, liquid nitrogen is not available in special environments, such as the International Space Station (ISS), and vitrified embryos must be stored at −80°C. Recently, the hi
Externí odkaz:
https://doaj.org/article/f87a18adb9764d4a96fb8d8d79088e4e
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Endogenous retroviruses (ERVs) in the mammalian genome play diverse roles in embryonic development. These developmentally related ERVs are generally repressed in somatic cells and therefore are likely repressed in embryos derived from somatic cell nu
Externí odkaz:
https://doaj.org/article/0adb446557e44178a104b702044b1e60
Autor:
Keiji Mochida, Ayumi Hasegawa, Daiki Shikata, Nobuhiko Itami, Masashi Hada, Naomi Watanabe, Toshiko Tomishima, Atsuo Ogura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cryopreservation of mouse spermatozoa is widely used for the efficient preservation and safe transport of valuable mouse strains. However, the current cryopreservation method requires special containers (plastic straws), undefined chemicals
Externí odkaz:
https://doaj.org/article/bc39811397874fd4bcdd714e9d6a1b3d
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Male germ cells undergo complex developmental processes eventually producing spermatozoa through spermatogenesis, although the molecular mechanisms remain largely elusive. We have previously identified somatic cell nuclear transfer-reprogram
Externí odkaz:
https://doaj.org/article/374cdb8ab5d348a38dd1a31ada6dd9d3