Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Atsuo Nakazaki"'
Publikováno v:
ACS Omega, Vol 2, Iss 2, Pp 487-495 (2017)
Externí odkaz:
https://doaj.org/article/f7507f550bd0432bb3b2fca332e8f611
Autor:
Toshiaki Aoki, Kensuke Ohnishi, Masaaki Kimoto, Satoshi Fujieda, Kouji Kuramochi, Toshifumi Takeuchi, Atsuo Nakazaki, Nobuo Watanabe, Fumio Sugawara, Takao Arai, Susumu Kobayashi
Publikováno v:
Pharmaceuticals, Vol 3, Iss 4, Pp 1063-1069 (2010)
We developed an efficient, stereoselective synthetic method for the diketopiperazine moiety of neoechinulin A and its derivatives. The intramolecular cyclization at 80 ºC proceeded with minimal racemization of the stereogenic center at C-12 on neoec
Externí odkaz:
https://doaj.org/article/b78c6fa0cc544c91a93abd0b67bfe82e
Autor:
Toshio Nishikawa, Yoshiki Ono, Keiko Higuchi, Masashi Yamaguchi, Kumi Sugino, Atsuo Nakazaki, Masaatsu Adachi
Publikováno v:
Synlett. 34:364-368
A new strategy for the convergent synthesis of the ABCD ring system of indole terpene alkaloids has been developed based on a Sonogashira coupling of an o-iodoaniline (the A ring) with an alkyne bearing the D ring. After a tandem palladium-catalyzed
Publikováno v:
Synlett. 34:958-962
An asymmetric total synthesis of picrotoxinin was performed by using a Mizoroki–Heck reaction of an enantioenriched tricyclic lactone with isopropenyl bromide as a key transformation, permitting the highly diastereoselective introduction of the req
Publikováno v:
Organic & Biomolecular Chemistry. 20:6432-6435
The structure of petromyzestrosterol, a pheromonal steroid of the sea lamprey, was verified by total syntheses of both C14-epimers of its 3-O-methyl derivative.
Autor:
Chengwei Liu, Masanobu Uchiyama, Hajime Sato, Yulu Jiang, Masaatsu Adachi, Junichiro Kanazawa, Tadachika Miyasaka, Mei Harada, Taro Ozaki, Atsushi Minami, Atsuo Nakazaki, Hideaki Oikawa, Toshio Nishikawa, Kazunori Miyamoto, Jun-ichi Maruyama
Publikováno v:
Angewandte chemie-international edition. 59(41):17996-18002
Lolitrems are tremorgenic indole diterpenes that exhibit a unique 5/6 bicyclic system of the indole moiety. Although genetic analysis has indicated that the prenyltransferase LtmE and the cytochrome P450 LtmJ are involved in the construction of this
Publikováno v:
The Journal of Organic Chemistry. 85:7534-7542
Chartelline C, a marine alkaloid, possesses a unique core scaffold including indolenine β-lactam and imidazole moieties linked by an unsaturated 10-membered ring. A new synthetic approach for the construction of the indolenine β-lactam was planned,
Publikováno v:
Free Radical Biology and Medicine. 152:197-206
Thiamine, a water-soluble essential vitamin known as vitamin B1, acts as an important cofactor in various cellular processes, such as metabolism and energy production. Thiamine is also thought to have antioxidant effects as a singlet oxygen scavenger
Publikováno v:
The Journal of Organic Chemistry. 85:4848-4860
The highly oxidized natural products chaxine B and BB have been synthesized from ergosterol in eight steps according to a route inspired by their proposed biosynthesis; key steps were an oxidative cascade from a furan intermediate to an enol ester us
Autor:
Yoshihiko Nokura, Kazuhiro Irie, Koutaro Hayakawa, Masaki Kita, Atsuo Nakazaki, Toshio Nishikawa, Yusuke Araki, Yusuke Hanaki
Publikováno v:
Bioscience, biotechnology, and biochemistry. 85(6)
Oscillatoxins (OTXs) and aplysiatoxins are biosynthetically related polyketides produced by marine cyanobacteria. We previously developed a synthetic route to phenolic O-methyl analogs of OTX-D and 30-methyl-OTX-D during collective synthesis of these