Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Atsuo Kuki"'
Autor:
Frank M Szaba, Michael Tighe, Lawrence W Kummer, Kathleen G Lanzer, Jerrold M Ward, Paula Lanthier, In-Jeong Kim, Atsuo Kuki, Marcia A Blackman, Stephen J Thomas, Jr-Shiuan Lin
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006994 (2018)
Zika virus (ZIKV) infection during human pregnancy may cause diverse and serious congenital defects in the developing fetus. Previous efforts to generate animal models of human ZIKV infection and clinical symptoms often involved manipulating mice to
Externí odkaz:
https://doaj.org/article/c4d364ef923349d88c10980ae8b73083
Autor:
Tran Khanh Tuan, Qiyue Hu, Zhang Junhu, Scott L. Butler, Atsuo Kuki, Qinghai Peng, Erik Jon Flahive, Graham L. Smith, Huichun Zhu, Deepak Dalvie, Plewe Michael Bruno, Jim Solowiej, Dorothy Delisle, Ted William Johnson, Wen Liu, Steven P. Tanis, Klaus Ruprecht Dress, Jon E. Kuehler, Guy A. McClellan, Xiaoming Yu, Hai Wang, Paul F. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 54:3393-3417
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the synthesis of orally bioavailable a
Autor:
Qinghai Peng, Tran Khanh Tuan, Atsuo Kuki, Steven P. Tanis, Zhang Junhu, Deepak Dalvie, Yang Anle, Xiaoming Yu, Jim Solowiej, Ted William Johnson, Hai Wang, Wen Liu, Plewe Michael Bruno, Buwen Huang, Graham L. Smith, Jon E. Kuehler, Klaus Ruprecht Dress, Chunfeng Yin, Qiyue Hu, Dorothy Delisle, Huichun Zhu, Scott L. Butler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7429-7434
HIV-1 integrase is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the discovery of azaindole hydroxamic acids
Autor:
Qinghai Peng, Nowlin Dawn Marie, Hieu Lam, Ted William Johnson, Yang Anle, Wen Liu, Atsuo Kuki, Steven P. Tanis, Jon E. Kuehler, Zhang Junhu, Hai Wang, Plewe Michael Bruno, Scott L. Butler, Tran Khanh Tuan, Qiyue Hu, Sadayappan V. Rahavendran, Klaus Ruprecht Dress
Publikováno v:
Journal of Medicinal Chemistry. 52:7211-7219
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication. Recently, HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Herein, we report the discovery of azaindole carboxyli
Autor:
Jesper Lau, James Lakis, Shenghua Shi, Javier Gonzalez, Teston Kimberly Ann, Lotte Bjerre Knudsen, Yufeng Hong, John M. May, Douglas E. Murphy, Atsuo Kuki, Dan Kiel, Anthony Lai Ling, Kenna Anderes, Alex Polinsky, Vlad E. Gregor, John B. Porter
Publikováno v:
Journal of Medicinal Chemistry. 44:3141-3149
High throughput screening of our small molecule combinatorial library identified a class of benzoylnaphthalenehydrazones with modest affinity for the human glucagon receptor. Optimization of this initial hit through a series of targeted libraries and
Publikováno v:
Journal of Molecular Graphics and Modelling. 18:478-496
Two combinatorial filtering methods for efficiently selecting reaction products with desired properties are presented. The first, “direct reactants” method is applicable only to those molecular properties that are strictly additive or approximate
Autor:
and James M. Gruschus, Atsuo Kuki
Publikováno v:
The Journal of Physical Chemistry B. 103:11407-11414
A formulation of long-range electronic coupling in electron transfer proteins based on the wave function tails of the donor and acceptor states is presented. These wave function tails, calculated by the IAL Hamiltonian method for cytochrome c and cyt
Publikováno v:
The Journal of Physical Chemistry B. 102:2076-2084
We present an analytical model that describes the coupling of protein fluctuations to electron transfer. The model treats both the protein and the bulk solvent to couple to electron transfer. The protein is represented by a low-dielectric cavity cont
Publikováno v:
The Journal of Physical Chemistry B. 102:2085-2094
In an accompanying paper (part 1) we presented a model (NMRES) that describes the coupling of protein fluctuations to electron transfer. The NMRES model, employing normal mode analysis that incorpo...
Autor:
Atsuo Kuki, Kamil Lang, William Chrisman, Enugurthi Brahmachary, Demetrios Anglos, Sambasivarao Kotha, Bakthan Singaram
Publikováno v:
Scopus-Elsevier
A novel constrained 7-amino-6,7-dihydro-8H-cyclopenta[g]quinoxaline-7-carboxylic acid derivative was prepared starting from 4,5-dimethyl-o-phenylenediamine. (C) 1997 .