Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Atsumi Iijima"'
Autor:
Kyosuke Kitoh, N. Tamai, Yoshihiko Kotake, Yoichi Ozawa, Atsumi Iijima, Kentaro Yoshimatsu, Hiroaki Nomura, Nozomu Koyanagi
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e84ff65ce2ef3128652b8b863d310b0
https://doi.org/10.1002/chin.199443240
https://doi.org/10.1002/chin.199443240
Publikováno v:
ChemInform. 26
Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2, 4-diamino-6, 7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid (1), have led to the synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::351f989a69bcf7f158b11c5c21e71ab0
https://doi.org/10.1002/chin.199545188
https://doi.org/10.1002/chin.199545188
Publikováno v:
Chemicalpharmaceutical bulletin. 43(5)
Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5- yl)propyl]benzoyl]-L-glutamic acid (1), have led to the synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31ef4c6c9d33529ca1ef820acf06c76
https://pubmed.ncbi.nlm.nih.gov/7553969
https://pubmed.ncbi.nlm.nih.gov/7553969
Autor:
Yoshihiko Kotake, Kyosuke Kitoh, Hiroaki Nomura, Kentaro Yoshimatsu, Yoichi Ozawa, Nozomu Koyanagi, Atsumi Iijima, Naoko Tamai
Publikováno v:
Journal of medicinal chemistry. 37(11)
Novel antifolates with a 6-5 fused ring system, 6,7-dihydrocyclopenta [d]pyrimidine, (3a,b and 4a,b) were synthesized on the basis of combined modification of the heterocycle and bridge regions of the folate molecule. The synthetic method involves (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f0f93b92f20e8b8ea51e18e38d4819
https://pubmed.ncbi.nlm.nih.gov/8201595
https://pubmed.ncbi.nlm.nih.gov/8201595
Autor:
Hiroshi Yoshino, Norihiro Ueda, Jun Niijima, Hiroyuki Sugumi, Yoshihiko Kotake, Nozomu Koyanagi, Kentaro Yoshimatsu, Makoto Asada, Tatsuo Watanabe, Takeshi Nagasu, Kappei Tsukahara, Atsumi Iijima, Kyosuke Kitoh
Publikováno v:
Journal of medicinal chemistry. 35(13)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b26ba5147b01a45682f3bedd259a318
https://pubmed.ncbi.nlm.nih.gov/1619621
https://pubmed.ncbi.nlm.nih.gov/1619621
Autor:
Atsumi Iijima, Makoto Asada, Yoshikazu Hasegawa, Kyosuke Kitoh, Toshiaki Wakabayashi, Takeshi Nagasu, Yasushi Shikata
Publikováno v:
The Journal of biological chemistry. 265(13)
Human lymphotoxin (hLT) and its mutant genes have been constructed by in vitro mutagenesis and expressed in Escherichia coli. A deletion of Lys84 to Lys89 in hLT remarkably enhanced both the cytotoxicity against human WiDr cells (colon adenocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693b588977493921c48bab0a50fab8f8
https://pubmed.ncbi.nlm.nih.gov/2159004
https://pubmed.ncbi.nlm.nih.gov/2159004