Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Atsuko Nishiguchi"'
Publikováno v:
Tetrahedron. 74:5779-5790
A practical chromatography-free synthesis of a potent polo-like kinase-1 inhibitor possessing a unique 5,6-dihydroimidazolo[1,5-f]pteridine structure has been developed. We showed that key cyanoimidazole ring formation could be conducted at benign te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::772b9be03a20069e4160db75b58c213b
https://doi.org/10.1016/j.tet.2018.08.020
https://doi.org/10.1016/j.tet.2018.08.020
Phosphine-Catalyzed Enantioselective Intramolecular [3+2] Annulations To Generate Fused Ring Systems
Publikováno v:
Journal of the American Chemical Society
Substantial progress has been described in the development of asymmetric variants of the phosphine-catalyzed intermolecular [3+2] annulation of allenes with alkenes; however, there have not been corresponding advances for the intramolecular process,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5afb3fdc427baafc3720fafaf74b56
https://doi.org/10.1021/jacs.5b01985
https://doi.org/10.1021/jacs.5b01985
Publikováno v:
Tetrahedron. 63:4048-4051
A convenient synthesis method of antisepsis agent TAK-242 ((R)-1) through diastereomeric resolution was developed. By condensation of racemate rac-1 with chiral acid (S)-O-acetylmanderic acid (6a), the desired diastereomer 5a was isolated with 98% de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b633ddc94a7b86498413577f1906ef8d
https://doi.org/10.1016/j.tet.2007.02.127
https://doi.org/10.1016/j.tet.2007.02.127
Publikováno v:
ChemInform. 46
A simple protocol employing the chiral phosphine catalysts (I) is presented for the synthesis of diquinane, fused pyrrolidine, coumarine, and quinoline derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72547e3e69605f3f296e2ab564537f6f
https://doi.org/10.1002/chin.201536038
https://doi.org/10.1002/chin.201536038
Publikováno v:
Tetrahedron. 61:5043-5048
The sulfide 4 was treated with chiral acid in a mixture of toluene and methyl iso -butylketone to precipitate the salt, which reacted with 30% H 2 O 2 for 3 weeks at rt. The resulting crystals were collected followed by recrystallization to give the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a528f7ce2b8c7375fb5c0d68d1474b6f
https://doi.org/10.1016/j.tet.2005.03.036
https://doi.org/10.1016/j.tet.2005.03.036
Publikováno v:
Organic Process Research & Development. 9:168-173
A practical method of synthesizing 7-{4-[2-(butoxy)ethoxy]phenyl}-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxamide (8), an orally active CCR5 antagonist, has been developed. Methyl 7-brom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91e1332e18c540df6ca6f390ed4a01e8
https://doi.org/10.1021/op0497916
https://doi.org/10.1021/op0497916
Publikováno v:
Tetrahedron Letters. 45:9335-9339
A convenient large-scalable synthesis of 1-benzazepines 19 as an important intermediate of CCR5 antagonist, oral HIV-1 therapy, was established. The anilination of o -halogenobenzaldehyde 9 with alkylamino-acid 16 gave o -formylaniline-acid 17 . Comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9635bf801abb374ba5b1a86ae77876
https://doi.org/10.1016/j.tetlet.2004.10.120
https://doi.org/10.1016/j.tetlet.2004.10.120
Autor:
Kiminori Tomimatsu, Mitsuhiro Wakimasu, Atsuko Nishiguchi, Hiroyuki Mitsudera, Tomomi Ikemoto
Publikováno v:
Tetrahedron. 57:1525-1529
A convenient and efficient synthesis of TAK-779 (1a), a nonpeptide CCR5 antagonist, has been achieved. The new methylation of tertiary amine (2) using trimethyl phosphite and N-chlorosuccinimide, followed by the addition of HCl led to ammonium chlori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a03c0d58bb8704ae199863b59c586e5
https://doi.org/10.1016/s0040-4020(00)01093-0
https://doi.org/10.1016/s0040-4020(00)01093-0
Autor:
Atsuko Nishiguchi, and Mitsuhiro Wakimasu, Hiroyuki Mitsudera, Kiminori Tomimatsu, Hideo Hashimoto, Tadao Kawarasaki, Tomomi Ikemoto, Tatsuya Ito
Publikováno v:
Organic Process Research & Development. 4:520-525
A new large-scalable preparation of TAK-779 (1), a non-peptide CCR5 antagonist, has been developed. The route selection was focused on in the process research. The selective reduction of commercially available benzonitrile derivative (4) as the start
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60bc326a1c8bf333a0df360d8a66fe12
https://doi.org/10.1021/op000074v
https://doi.org/10.1021/op000074v
Publikováno v:
The Journal of Organic Chemistry. 65:6922-6931
A combination of sulfanyl radical addition-cyclization of dienes connected with hydroximates and subsequent conversion of the resulting cyclic hydroximate to the lactones provides a novel method for the construction of alpha,beta-disubstituted gamma-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390ae41c30dca4a3ee948a03eb6a550c
https://doi.org/10.1021/jo000472w
https://doi.org/10.1021/jo000472w