Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Atsuko Nagaoka"'
Autor:
Atsuko Nagaoka, Mizuki Hino, Ryuta Izumi, Risa Shishido, Miki Ishibashi, Masataka Hatano, Makoto Sainouchi, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 2, Pp 399-409 (2024)
Abstract Aim Postmortem brain research is necessary for elucidating the pathology of schizophrenia; an increasing number of studies require a combination of suitable tissue samples preserved at multiple brain banks. In this study, we examined whether
Externí odkaz:
https://doaj.org/article/e19f62b72bd64341a982eb3f469f2bd4
Autor:
Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 1, Pp 121-128 (2024)
Abstract Aim The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in BD have received increasing attention in recent years. In this study, we examined the expression levels of enzyme proteins associated with the metabol
Externí odkaz:
https://doaj.org/article/6e606ffe19e94b8daa0f3078d123b804
Autor:
Kazusa Miyahara, Mizuki Hino, Risa Shishido, Atsuko Nagaoka, Ryuta Izumi, Hideki Hayashi, Akiyoshi Kakita, Hirooki Yabe, Hiroaki Tomita, Yasuto Kunii
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Schizophrenia is a multifactorial disorder, the genetic architecture of which remains unclear. Although many studies have examined the etiology of schizophrenia, the gene sets that contribute to its symptoms have not been fully investigated.
Externí odkaz:
https://doaj.org/article/77eff89cc70b4749b806c704fa3ab4c3
Autor:
Risa Shishido, Yasuto Kunii, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
BackgroundSchizophrenia (SZ) is a disorder diagnosed by specific symptoms and duration and is highly heterogeneous, clinically and pathologically. Although there are an increasing number of studies on the association between genetic and environmental
Externí odkaz:
https://doaj.org/article/4f4d492250b14b828594cd804814bc89
Autor:
Kazusa Miyahara, Mizuki Hino, Zhiqian Yu, Chiaki Ono, Atsuko Nagaoka, Masataka Hatano, Risa Shishido, Hirooki Yabe, Hiroaki Tomita, Yasuto Kunii
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
BackgroundEvaluating and controlling confounders are necessary when investigating molecular pathogenesis using human postmortem brain tissue. Particularly, tissue pH and RNA integrity number (RIN) are valuable indicators for controlling confounders.
Externí odkaz:
https://doaj.org/article/957c8a4e574a4db4afe10681d1ff595e
Autor:
Tetsuo Ohnishi, Shabeesh Balan, Manabu Toyoshima, Motoko Maekawa, Hisako Ohba, Akiko Watanabe, Yoshimi Iwayama, Yuko Fujita, Yunfei Tan, Yasuko Hisano, Chie Shimamoto-Mitsuyama, Yayoi Nozaki, Kayoko Esaki, Atsuko Nagaoka, Junya Matsumoto, Mizuki Hino, Nobuko Mataga, Akiko Hayashi-Takagi, Kenji Hashimoto, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Takeo Yoshikawa
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 432-446 (2019)
Background: Betaine is known to act against various biological stresses and its levels were reported to be decreased in schizophrenia patients. We aimed to test the role of betaine in schizophrenia pathophysiology, and to evaluate its potential as a
Externí odkaz:
https://doaj.org/article/8e044d4f4b674d4db13d08c405718559
Autor:
Ryuta Izumi, Mizuki Hino, Akira Wada, Atsuko Nagaoka, Takashi Kawamura, Tsutomu Mori, Makoto Sainouchi, Akiyoshi Kakita, Kiyoto Kasai, Yasuto Kunii, Hirooki Yabe
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Recent studies have lent support to the possibility that inflammation is associated with the pathology of schizophrenia. In the study of measurement of inflammatory mediators, which are markers of inflammation, elevated inflammatory cytokine levels i
Externí odkaz:
https://doaj.org/article/603c7ff9777d4e9b8923d34e0f151441
Autor:
Shinobu Hirai, Atsuhiro Sakuma, Yasuto Kunii, Hiroko Shimbo, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Rika Kojima, Erika Seki, Nobutaka Arai, Takashi Komori, Haruo Okado
Publikováno v:
Journal of Psychiatric Research. 163:74-79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d98a99f01a8e38ae112c9005db7db46
https://doi.org/10.1016/j.jpsychires.2023.04.011
https://doi.org/10.1016/j.jpsychires.2023.04.011
Autor:
Ryuta Izumi, Risa Shishido, Hirooki Yabe, Mikio Hoshino, Yasuto Kunii, Akiyoshi Kakita, Atsuko Nagaoka, Mizuki Hino
Publikováno v:
Neuroscience Research. 175:73-81
The mechanistic target of rapamycin (mTOR)-signaling and dihydropyrimidinase-like 2 (DPYSL2), which are increasingly gaining attention as potential therapeutic targets for schizophrenia, are connected via Cap-dependent translation of the 5'TOP motif.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a119300e459ce37b749cf91b9ddb99ac
https://doi.org/10.1016/j.neures.2021.09.004
https://doi.org/10.1016/j.neures.2021.09.004
Autor:
Yuriko Iwakura, Ryoka Kawahara-Miki, Satoshi Kida, Hidekazu Sotoyama, Ramil Gabdulkhaev, Hitoshi Takahashi, Yasuto Kunii, Mizuki Hino, Atsuko Nagaoka, Ryuta Izumi, Risa Shishido, Toshiyuki Someya, Hirooki Yabe, Akiyoshi Kakita, Hiroyuki Nawa
Publikováno v:
Neurochemical research. 47(9)
The family of epidermal growth factor (EGF) including neuregulin-1 are implicated in the neuropathology of schizophrenia. We established a rat model of schizophrenia by exposing perinatal rats to EGF and reported that the auditory pathophysiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3c0b4ff930b203677bc5f7457bd72b
https://pubmed.ncbi.nlm.nih.gov/35469366
https://pubmed.ncbi.nlm.nih.gov/35469366