Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Atsuko Miyajima"'
Autor:
Atsuko Miyajima, Yukie Kuroda, Kazue Sakemi-Hoshikawa, Makoto Usami, Katsuyoshi Mitsunaga, Tomohiko Irie, Yasuo Ohno, Momoko Sunouchi
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 979-985 (2020)
Effects of 4-methyl-2-mercaptobenzimidazole (4-MeMBI) and 5-methyl-2- mercaptobenzimidazole (5-MeMBI) on cytochrome P450 (CYP) activity were examined in primary cultured rat hepatocytes. Hepatocytes from male Wistar rats were cultured in the presence
Externí odkaz:
https://doaj.org/article/2baa9904a5d44238b2664d345c8d630b
Autor:
Tsuyoshi Kawakami1 tkawa@nihs.go.jp, Atsuko Miyajima2, Kaoru Komoriya2, Reiko Kato2, Kazuo Isama3
Publikováno v:
Journal of Toxicological Sciences. Apr2022, Vol. 47 Issue 4, p151-157. 7p.
Publikováno v:
Fundamental Toxicological Sciences. 8:205-213
Autor:
Yukie Kuroda, Tomohiko Irie, Momoko Sunouchi, Makoto Usami, Katsuyoshi Mitsunaga, Atsuko Miyajima, Yasuo Ohno, Kazue Sakemi-Hoshikawa
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 979-985 (2020)
Toxicology Reports, Vol 7, Iss, Pp 979-985 (2020)
Highlights • 4-MeMBI, 5-MeMBI and MBI inhibit CYP3A2 activity in cultured rat hepatocytes. • 4-MeMBI and 5-MeMBI, not MBI, induce CYP1A1/2 activity in cultured rat hepatocytes. • Effects of the chemicals on CYP3A2 suggest metabolic drug-drug in
Autor:
Atsuko Miyajima, Yasuo Ohno, Kazue Sakemi-Hoshikawa, Yukie Kuroda, Katsuyoshi Mitsunaga, Makoto Usami, Momoko Sunouchi
Publikováno v:
Fundamental Toxicological Sciences. 7:249-252
Autor:
Masami Aizawa, Hideyuki Sakoda, Atsuko Miyajima, Yuji Haishima, Miyuki Uematsu, Ryusuke Nakaoka, Hitomi Toida, Asako Ueda
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 141(2)
Pharmaceuticals reportedly cause damage to some polymeric medical devices that administer them. Because this phenomenon and its causes still remain unclear, in this study, all the possible combinations of polymeric materials and pharmaceutical ingred
Autor:
Makoto Usami, Yasuo Ohno, Kazue Sakemi-Hoshikawa, Momoko Sunouchi, Atsuko Miyajima, Yukie Kuroda, Tomohiko Irie, Katsuyoshi Mitsunaga
Publikováno v:
Fundamental Toxicological Sciences. 5:113-116
Autor:
Makoto Usami, Tomohiko Irie, Yasuo Ohno, Atsuko Miyajima, Katsuyoshi Mitsunaga, Kazue Sakemi-Hoshikawa, Momoko Sunouchi
Publikováno v:
Biochemical and Biophysical Research Communications. 492:116-120
We examined the effects of thyrotoxic rubber antioxidants, 2-mercaptobenzimidazole (MBI, 0.3 mmol/kg/day) and its methyl derivatives, methyl-MBIs [4-methyl-MBI (4-MeMBI, 0.6 mmol/kg/day), 5-methyl-MBI (5-MeMBI, 0.6 mmol/kg/day), and 4(or 5)-methyl-MB
Autor:
Shugo Kazama, Tatsuya Takizawa, Tomohiko Irie, Mina Takamatu, Osamu Doi, Makoto Usami, Atsuko Miyajima, Katsuyoshi Mitsunaga
Publikováno v:
Congenital Anomalies. 56:52-59
The inhibition of neural crest cell (NCC) migration has been considered as a possible pathogenic mechanism underlying chemical developmental toxicity. In this study, we examined the effects of 13 developmentally toxic chemicals on the migration of ra
Publikováno v:
Toxicology in Vitro. 68:104919
In biological safety evaluation of medical devices, false-negative results have been observed during skin irritation testing using the reconstructed human epidermis (RhE) model when measuring cell viability as a single marker. Therefore, to improve t